Organism : Bacillus cereus ATCC14579 | Module List :
BC2964

Deoxyribonucleoside regulator (NCBI ptt file)

CircVis
Functional Annotations (3)
Function System
Transcriptional regulator, contains sigma factor-related N-terminal domain cog/ cog
carbohydrate binding go/ molecular_function
transcription regulator activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2964
(Mouseover regulator name to see its description)

BC2964 is regulated by 20 influences and regulates 48 modules.
Regulators for BC2964 (20)
Regulator Module Operator
BC0742 463 tf
BC1329 463 tf
BC1363 463 tf
BC2401 463 tf
BC2469 463 tf
BC2680 463 tf
BC2964 463 tf
BC3160 463 tf
BC3588 463 tf
BC4930 463 tf
BC5176 463 tf
BC5411 463 tf
BC1329 115 tf
BC2410 115 tf
BC2469 115 tf
BC2517 115 tf
BC2964 115 tf
BC3587 115 tf
BC3588 115 tf
BC5282 115 tf

Warning: BC2964 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4146 4.60e+01 AAgAGG
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4147 4.50e+00 AgGGAtGA
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4836 1.20e-02 ggAAgGaG
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4837 9.40e+03 cA.gAgccaGttgTa
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2964

BC2964 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Transcriptional regulator, contains sigma factor-related N-terminal domain cog/ cog
carbohydrate binding go/ molecular_function
transcription regulator activity go/ molecular_function
Module neighborhood information for BC2964

BC2964 has total of 31 gene neighbors in modules 115, 463
Gene neighbors (31)
Gene Common Name Description Module membership
BC0635 BC0635 Spore germination protein KA (NCBI ptt file) 115, 339
BC0702 BC0702 hypothetical protein (NCBI ptt file) 135, 463
BC0869 BC0869 hypothetical protein (NCBI ptt file) 17, 463
BC0947 BC0947 hypothetical protein (NCBI ptt file) 463, 521
BC1321 BC1321 hypothetical protein (NCBI ptt file) 115, 289
BC1402 BC1402 3-isopropylmalate dehydratase large subunit (NCBI ptt file) 32, 463
BC2010 BC2010 hypothetical Membrane Spanning Protein (NCBI ptt file) 334, 463
BC2146 BC2146 IG hypothetical 15966 (NCBI ptt file) 109, 115
BC2334 BC2334 hypothetical Membrane Spanning Protein (NCBI ptt file) 115, 153
BC2336 BC2336 hypothetical Membrane Spanning Protein (NCBI ptt file) 115, 267
BC2425 BC2425 Phage-related protein (NCBI ptt file) 463, 521
BC2567 BC2567 Phage protein (NCBI ptt file) 184, 463
BC2574 BC2574 Phage-related protein (NCBI ptt file) 463, 521
BC2588 BC2588 Phage protein (NCBI ptt file) 115, 317
BC2648 BC2648 Myo-inositol-1-phosphate synthase (NCBI ptt file) 291, 463
BC2764 BC2764 hypothetical Membrane Spanning Protein (NCBI ptt file) 415, 463
BC2831 BC2831 Sodium/proton-dependent alanine carrier protein (NCBI ptt file) 115, 448
BC2836 BC2836 Sarcosine oxidase beta subunit (NCBI ptt file) 106, 463
BC2925 BC2925 Nucleotidyltransferase (NCBI ptt file) 115, 324
BC2964 BC2964 Deoxyribonucleoside regulator (NCBI ptt file) 115, 463
BC2966 BC2966 Polyketide synthase curC (NCBI ptt file) 115, 196
BC3003 BC3003 hypothetical protein (NCBI ptt file) 463, 521
BC3059 BC3059 putative cephalosporin hydroxylase CmcI (NCBI ptt file) 131, 463
BC3213 BC3213 hypothetical protein (NCBI ptt file) 463, 521
BC3242 BC3242 Hydrogenase expression/formation protein hypE (NCBI ptt file) 35, 115
BC3359 BC3359 CDP-glucose 4,6-dehydratase (NCBI ptt file) 289, 463
BC3361 BC3361 CDP-4-dehydro-6-deoxy-D-gulose 4-reductase (NCBI ptt file) 16, 463
BC3582 BC3582 hypothetical protein (NCBI ptt file) 106, 115
BC3875 BC3875 Xaa-Pro dipeptidase (NCBI ptt file) 115, 168
BC3992 BC3992 hypothetical protein (NCBI ptt file) 289, 463
BC4284 BC4284 VrrA protein (NCBI ptt file) 106, 115
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2964
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend