Organism : Bacillus cereus ATCC14579 | Module List :
BC5317

hypothetical protein (NCBI ptt file)

CircVis
Functional Annotations (2)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
TIGR01440 tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC5317
(Mouseover regulator name to see its description)

BC5317 is regulated by 24 influences and regulates 0 modules.
Regulators for BC5317 (24)
Regulator Module Operator
BC2358 103 tf
BC3758 103 tf
BC4240 103 tf
BC4256 103 tf
BC4672 103 tf
BC5265 103 tf
BC5332 103 tf
BC0042 28 tf
BC0405 28 tf
BC0880 28 tf
BC1680 28 tf
BC1850 28 tf
BC2358 28 tf
BC2815 28 tf
BC2979 28 tf
BC3522 28 tf
BC4240 28 tf
BC4425 28 tf
BC4670 28 tf
BC5143 28 tf
BC5176 28 tf
BC5191 28 tf
BC5265 28 tf
BC5481 28 tf

Warning: BC5317 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3978 8.60e+02 aAGaaGgA
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3979 4.10e+03 GGtAGCG
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4122 6.80e+02 gAAAaaaGgaG
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4123 1.30e+03 ATGaGAaGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC5317

BC5317 is enriched for 2 functions in 3 categories.
Enrichment Table (2)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
TIGR01440 tigr/ tigrfam
Module neighborhood information for BC5317

BC5317 has total of 46 gene neighbors in modules 28, 103
Gene neighbors (46)
Gene Common Name Description Module membership
BC0042 BC0042 Transcription state regulatory protein abrB (NCBI ptt file) 28, 74
BC0220 BC0220 Molybdenum transport system permease protein modB (NCBI ptt file) 28, 380
BC0336 BC0336 Somatin-like protein (NCBI ptt file) 103, 337
BC0435 BC0435 Transcriptional regulator, PBSX family (NCBI ptt file) 103, 443
BC0466 BC0466 Fumarate hydratase (NCBI ptt file) 28, 430
BC0472 BC0472 hypothetical protein (NCBI ptt file) 28, 119
BC0482 BC0482 PTS system, N-acetylglucosamine-specific IIBC component (NCBI ptt file) 103, 290
BC1387 BC1387 Transcriptional regulator, MarR family (NCBI ptt file) 28, 380
BC1463 BC1463 Purine nucleoside phosphorylase (NCBI ptt file) 28, 187
BC1615 BC1615 Na+ driven multidrug efflux pump (NCBI ptt file) 92, 103
BC1926 BC1926 Low-affinity zinc transport protein (NCBI ptt file) 103, 478
BC2153 BC2153 hypothetical protein (NCBI ptt file) 28, 227
BC2215 BC2215 Mechanosensitive ion channel (NCBI ptt file) 28, 187
BC2356 BC2356 Ribosomal-protein-alanine acetyltransferase (NCBI ptt file) 28, 100
BC2437 BC2437 hypothetical protein (NCBI ptt file) 28, 475
BC2815 BC2815 ATP-dependent DNA helicase recQ (NCBI ptt file) 28, 228
BC3758 BC3758 Transcriptional regulator, GntR family (NCBI ptt file) 103, 430
BC3925 BC3925 None 103, 247
BC3981 BC3981 Tetrahydrodipicolinate N-acetyltransferase (NCBI ptt file) 103, 399
BC3987 BC3987 NRDH-redoxin (NCBI ptt file) 103, 477
BC4046 BC4046 hypothetical protein (NCBI ptt file) 28, 187
BC4085 BC4085 Pyrimidine-nucleoside phosphorylase (NCBI ptt file) 28, 401
BC4086 BC4086 Purine nucleoside phosphorylase (NCBI ptt file) 28, 475
BC4087 BC4087 Phosphopentomutase (NCBI ptt file) 28, 475
BC4139 BC4139 hypothetical protein (NCBI ptt file) 28, 119
BC4201 BC4201 hypothetical Membrane Spanning Protein (NCBI ptt file) 103, 298
BC4202 BC4202 hypothetical Membrane Spanning Protein (NCBI ptt file) 103, 298
BC4245 BC4245 hypothetical protein (NCBI ptt file) 28, 337
BC4384 BC4384 hypothetical protein (NCBI ptt file) 28, 227
BC4425 BC4425 hypothetical transcriptional regulator (NCBI ptt file) 28, 187
BC4610 BC4610 hypothetical protein (NCBI ptt file) 28, 224
BC4693 BC4693 Deblocking aminopeptidase (NCBI ptt file) 103, 385
BC4914 BC4914 None 103, 401
BC4917 BC4917 BioY protein (NCBI ptt file) 103, 350
BC4958 BC4958 NAD(P)H dehydrogenase [quinone] (NCBI ptt file) 103, 414
BC5052 BC5052 None 103, 126
BC5135 BC5135 Enolase (NCBI ptt file) 28, 188
BC5142 BC5142 Glutaredoxin (NCBI ptt file) 1, 28
BC5143 BC5143 RNA polymerase sigma-54 factor rpoN (NCBI ptt file) 1, 28
BC5176 BC5176 Transcriptional regulator, MerR family (NCBI ptt file) 28, 296
BC5177 BC5177 Trp repressor binding protein (NCBI ptt file) 28, 296
BC5256 BC5256 Transcriptional regulator, PBSX family (NCBI ptt file) 103, 245
BC5317 BC5317 hypothetical protein (NCBI ptt file) 28, 103
BC5318 BC5318 Ribose 5-phosphate isomerase (NCBI ptt file) 103, 385
BC5396 BC5396 hydrolase (HAD superfamily) (NCBI ptt file) 103, 126
BC5481 BC5481 Stage 0 sporulation protein J (NCBI ptt file) 28, 119
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC5317
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend