Organism : Bacillus cereus ATCC14579 | Module List :
BC5459

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC5459
(Mouseover regulator name to see its description)

BC5459 is regulated by 29 influences and regulates 0 modules.
Regulators for BC5459 (29)
Regulator Module Operator
BC0123 445 tf
BC0213 445 tf
BC0433 445 tf
BC0601 445 tf
BC0758 445 tf
BC0954 445 tf
BC0958 445 tf
BC1296 445 tf
BC1673 445 tf
BC1936 445 tf
BC1998 445 tf
BC2434 445 tf
BC3356 445 tf
BC3813 445 tf
BC4181 445 tf
BC5222 445 tf
BC5256 445 tf
BC5265 445 tf
BC5332 445 tf
BC0224 208 tf
BC0583 208 tf
BC0657 208 tf
BC1531 208 tf
BC2470 208 tf
BC3072 208 tf
BC3404 208 tf
BC3922 208 tf
BC4501 208 tf
BC5265 208 tf

Warning: BC5459 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4332 4.90e+03 gaaG.gaAaaaagaa..a.tGGA
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4333 7.90e+03 CcTcCCaCGC
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4800 1.30e-01 agGGAggTaTt
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4801 8.80e+00 aAa.aAgggGGAgAg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC5459

Warning: No Functional annotations were found!

Module neighborhood information for BC5459

BC5459 has total of 46 gene neighbors in modules 208, 445
Gene neighbors (46)
Gene Common Name Description Module membership
BC0550 BC0550 hypothetical protein (NCBI ptt file) 200, 208
BC0668 BC0668 (R,R)-butanediol dehydrogenase (NCBI ptt file) 43, 445
BC0883 BC0883 Acetolactate synthase large subunit (NCBI ptt file) 43, 445
BC0884 BC0884 Alpha-acetolactate decarboxylase (NCBI ptt file) 43, 445
BC1051 BC1051 Protein ecsB (NCBI ptt file) 117, 208
BC1100 BC1100 hypothetical protein (NCBI ptt file) 208, 427
BC1251 BC1251 Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (NCBI ptt file) 43, 445
BC1252 BC1252 2-oxoglutarate dehydrogenase E1 component (NCBI ptt file) 43, 445
BC1311 BC1311 Small acid-soluble spore protein (NCBI ptt file) 208, 460
BC1390 BC1390 Potassium uptake protein KtrB (NCBI ptt file) 43, 445
BC1491 BC1491 NAD-specific glutamate dehydrogenase (NCBI ptt file) 129, 445
BC1520 BC1520 hypothetical Cytosolic Protein (NCBI ptt file) 208, 268
BC2089 BC2089 hypothetical protein (NCBI ptt file) 208, 525
BC2093 BC2093 hypothetical protein (NCBI ptt file) 208, 460
BC2100 BC2100 Methyltransferase (NCBI ptt file) 113, 208
BC2223 BC2223 Gluconokinase (NCBI ptt file) 43, 445
BC2224 BC2224 Gluconate permease (NCBI ptt file) 43, 445
BC2225 BC2225 6-phosphogluconate dehydrogenase (NCBI ptt file) 43, 445
BC2230 BC2230 Macrolide-efflux protein (NCBI ptt file) 194, 208
BC2449 BC2449 Lipase/Acylhydrolase with GDSL-like motif (NCBI ptt file) 208, 377
BC2472 BC2472 None 445, 502
BC2707 BC2707 Acetyltransferase (NCBI ptt file) 208, 413
BC2932 BC2932 Phosphoglycerol transferase (NCBI ptt file) 43, 445
BC3041 BC3041 hypothetical protein (NCBI ptt file) 208, 254
BC3137 BC3137 Deoxyribodipyrimidine photolyase (NCBI ptt file) 208, 254
BC3149 BC3149 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI ptt file) 201, 208
BC3404 BC3404 Transcriptional regulator, MarR family (NCBI ptt file) 208, 414
BC3413 BC3413 Esterase (NCBI ptt file) 208, 413
BC3414 BC3414 hydrolase (NCBI ptt file) 113, 208
BC3419 BC3419 Long-chain-fatty-acid--CoA ligase (NCBI ptt file) 445, 491
BC3559 BC3559 Chloramphenicol-sensitive protein rarD (NCBI ptt file) 208, 527
BC3567 BC3567 None 104, 445
BC3568 BC3568 Formate transporter (NCBI ptt file) 398, 445
BC3569 BC3569 Molybdenum cofactor biosynthesis protein A (NCBI ptt file) 43, 445
BC3570 BC3570 FdhD protein (fdsC) (NCBI ptt file) 43, 445
BC3571 BC3571 hypothetical Cytosolic Protein (NCBI ptt file) 43, 445
BC3572 BC3572 hypothetical protein (NCBI ptt file) 43, 445
BC3573 BC3573 Formate dehydrogenase alpha chain (NCBI ptt file) 43, 445
BC3624 BC3624 None 208, 439
BC3818 BC3818 None 51, 445
BC4102 BC4102 Alpha/beta hydrolase (NCBI ptt file) 6, 208
BC4125 BC4125 hypothetical protein (NCBI ptt file) 47, 445
BC4501 BC4501 Germination protein gerE (NCBI ptt file) 13, 208
BC4977 BC4977 5'-nucleotidase (NCBI ptt file) 105, 445
BC5445 BC5445 Superoxide dismutase [Mn] (NCBI ptt file) 43, 445
BC5459 BC5459 None 208, 445
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC5459
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend