Organism : Bacillus subtilis | Module List :
BSU03750 yclJ

two-component response regulator [YclK] (RefSeq)

CircVis
Functional Annotations (5)
Function System
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cog/ cog
two-component response regulator activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
DNA binding go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU03750
(Mouseover regulator name to see its description)

BSU03750 is regulated by 31 influences and regulates 5 modules.
Regulators for BSU03750 yclJ (31)
Regulator Module Operator
BSU00560 37 tf
BSU00700 37 tf
BSU01640 37 tf
BSU02680 37 tf
BSU03750 37 tf
BSU04680 37 tf
BSU05330 37 tf
BSU08370 37 tf
BSU11650 37 tf
BSU16600 37 tf
BSU17080 37 tf
BSU33740 37 tf
BSU33990 37 tf
BSU34180 37 tf
BSU35650 37 tf
BSU37580 37 tf
BSU40960 37 tf
BSU40990 37 tf
BSU08340 258 tf
BSU08520 258 tf
BSU12370 258 tf
BSU12510 258 tf
BSU13310 258 tf
BSU17080 258 tf
BSU21780 258 tf
BSU23590 258 tf
BSU32140 258 tf
BSU32420 258 tf
BSU33660 258 tf
BSU33670 258 tf
BSU33790 258 tf

Warning: BSU03750 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5034 1.30e+01 t..CCgcgAGAAAagAc.Tac
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5035 5.40e+01 TtTtttaAaAaCGtT
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5456 2.90e-07 gtTgtgttacAataA.aGA.a.gG
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5457 4.90e+00 AGcGAATaacTTCTCtcaaCC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU03750

BSU03750 is enriched for 5 functions in 3 categories.
Module neighborhood information for BSU03750

BSU03750 has total of 59 gene neighbors in modules 37, 258
Gene neighbors (59)
Gene Common Name Description Module membership
BSU01140 ybaC putative proline iminopeptidase (RefSeq) 13, 37
BSU03670 dtpT di-tripeptide-proton ABC symporter (RefSeq) 258, 315
BSU03750 yclJ two-component response regulator [YclK] (RefSeq) 37, 258
BSU03760 yclK two-component sensor histidine kinase [YclJ] (RefSeq) 37, 258
BSU04770 ydcH putative transcriptional regulator (RefSeq) 151, 258
BSU05620 ydgF putative amino acid permease (RefSeq) 226, 258
BSU07330 yfnB putative hydrolase (RefSeq) 215, 258
BSU07390 yfmP transcriptional regulator (MerR family) of metal efflux transporter expression (RefSeq) 161, 258
BSU08340 padR transcriptional regulator (RefSeq) 216, 258
BSU08520 recX recombination regulator RecX (RefSeq) 94, 258
BSU08630 yfhQ A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase (RefSeq) 37, 314
BSU09610 yhdV integral membrane protein possibly involved in chromosome condensation (RefSeq) 94, 258
BSU09620 yhdW putative glycerophosphodiester phosphodiesterase (RefSeq) 23, 258
BSU12510 xre Phage PBSX transcriptional regulator (RefSeq) 191, 258
BSU13090 ykkC efflux transporter (RefSeq) 37, 66
BSU13310 tnrA nitrogen sensing transcriptional regulator (RefSeq) 216, 258
BSU14420 ykoA hypothetical protein (RefSeq) 219, 258
BSU14430 ykpA ABC efflux transporter (ATP-binding protein) (RefSeq) 142, 258
BSU14830 ylaM glutaminase (RefSeq) 258, 323
BSU16580 polC DNA polymerase III PolC (RefSeq) 37, 67
BSU17080 pksA putative transcriptional regulator (RefSeq) 191, 258
BSU17730 yndB hypothetical protein (RefSeq) 258, 323
BSU18830 pps phosphoenolpyruvate synthase (RefSeq) 37, 53
BSU19160 yocC hypothetical protein (RefSeq) 37, 397
BSU22830 gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (RefSeq) 37, 314
BSU22980 ypbG putative phosphoesterase (RefSeq) 94, 258
BSU23570 aspA aspartate ammonia-lyase (RefSeq) 258, 293
BSU23580 ansA exported L-asparaginase (RefSeq) 258, 293
BSU23590 ansR transcriptional regulator of ansAB (Xre family) (RefSeq) 151, 258
BSU23770 dsdA D-serine dehydratase (RefSeq) 1, 37
BSU23780 yqjQ putative metabolite dehydrogenase, NAD-binding (RefSeq) 1, 37
BSU23790 yqjP putative metal-dependent hydrolase (RefSeq) 37, 50
BSU24830 yqgT putative gamma-D-glutamyl-L-diamino acid endopeptidase (RefSeq) 37, 319
BSU27590 yrvI D-tyrosyl-tRNA(Tyr) deacylase (RefSeq) 37, 315
BSU27800 yrzH hypothetical protein (RefSeq) 64, 258
BSU28970 ytxB putative integral inner membrane protein (RefSeq) 37, 228
BSU29980 ytjP dipeptidase PepV (RefSeq) 37, 341
BSU29990 pbuO hypoxanthine/guanine permease (RefSeq) 1, 37
BSU30310 ytwF putative sulfur transferase (RefSeq) 258, 323
BSU31100 ktrB potassium transporter ATPase (RefSeq) 37, 397
BSU32170 dapF diaminopimelate epimerase (RefSeq) 164, 258
BSU32420 pucR transcriptional regulator of the purine degradation operon (RefSeq) 257, 258
BSU33370 yvgK putative molybdate binding regulator (RefSeq) 164, 258
BSU33450 helD DNA 3'-5' helicase IV (RefSeq) 1, 37
BSU33500 copA copper transporter ATPase (RefSeq) 37, 50
BSU33510 copZ copper insertion chaperone and transporter component (RefSeq) 37, 50
BSU33660 rghRA transcriptional repressor (RefSeq) 49, 258
BSU33670 rghRB putative transcriptional repressor (RefSeq) 49, 258
BSU33680 yvaP putative transcriptional regulator (RefSeq) 49, 258
BSU33780 sdpI integral inner membrane regulator of autophagy (RefSeq) 191, 258
BSU33790 sdpR transcriptional regulator (ArsR family) (RefSeq) 191, 258
BSU34420 yveF hypothetical protein (RefSeq) 174, 258
BSU36620 ywnB putative oxidoreductase (RefSeq) 37, 365
BSU36950 ywlC putative ribosome maturation factor; RNA binding protein (RefSeq) 37, 233
BSU37570 mmr toxic compound efflux transporter (RefSeq) 37, 50
BSU38290 thiE thiamine-phosphate pyrophosphorylase (RefSeq) 37, 262
BSU38300 thiM hydroxyethylthiazole kinase (RefSeq) 37, 262
BSU38840 yxkD efflux transporter (RefSeq) 37, 293
BSU40050 gntR transcriptional regulator (GntR family) (RefSeq) 37, 73
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU03750
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend