Organism : Bacteroides thetaiotaomicron VPI-5482 | Module List :
NP_813546.1 BT_4635

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for NP_813546.1
(Mouseover regulator name to see its description)

Warning: No Regulators were found for NP_813546.1!

Warning: NP_813546.1 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6060 1.20e+00 gCAAA.aTA
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6061 4.40e+04 GTTGTTTGTTGGC
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6268 1.20e-09 TAtcTTTGca
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6269 2.40e+03 CAAAaAAg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for NP_813546.1

Warning: No Functional annotations were found!

Module neighborhood information for NP_813546.1

NP_813546.1 has total of 67 gene neighbors in modules 168, 273
Gene neighbors (67)
Gene Common Name Description Module membership
NP_809085.1 BT_0172 None 272, 273
NP_809110.1 BT_0197 None 252, 273
NP_809129.1 BT_0216 None 273, 357
NP_809153.1 BT_0240 None 273, 428
NP_809180.1 BT_0267 None 168, 261
NP_809194.1 BT_0281 None 113, 273
NP_809449.1 BT_0536 None 27, 168
NP_809494.1 BT_0581 None 273, 405
NP_809549.1 BT_0636 None 68, 168
NP_809574.1 BT_0661 None 168, 416
NP_809623.1 BT_0710 None 168, 472
NP_809675.1 BT_0762 None 273, 323
NP_809835.1 BT_0922 None 68, 168
NP_809836.1 BT_0923 None 68, 273
NP_809857.1 BT_0944 None 44, 168
NP_809858.1 BT_0945 None 44, 168
NP_809879.1 BT_0966 None 273, 438
NP_809900.1 BT_0987 None 273, 349
NP_809954.1 BT_1041 None 168, 206
NP_809965.1 BT_1052 None 200, 273
NP_810051.1 BT_1138 None 156, 273
NP_810052.1 BT_1139 None 273, 349
NP_810053.1 BT_1140 None 273, 405
NP_810173.1 BT_1260 None 141, 168
NP_810174.1 BT_1261 None 58, 168
NP_810176.1 BT_1263 None 221, 273
NP_810342.1 BT_1429 None 117, 168
NP_810427.1 BT_1514 None 53, 273
NP_810522.1 BT_1609 None 53, 273
NP_810530.1 BT_1617 None 168, 208
NP_810689.1 BT_1776 None 156, 168
NP_810820.1 BT_1907 None 273, 428
NP_811015.1 BT_2102 None 273, 358
NP_811136.1 BT_2223 None 168, 429
NP_811138.1 BT_2225 None 168, 356
NP_811277.1 BT_2364 None 168, 198
NP_811293.1 BT_2380 None 273, 399
NP_811294.1 BT_2381 None 168, 261
NP_811296.1 BT_2383 None 273, 344
NP_811451.1 BT_2538 None 177, 273
NP_811459.1 BT_2546 None 156, 168
NP_811504.1 BT_2591 None 273, 347
NP_811569.1 BT_2656 None 168, 450
NP_811700.1 BT_2788 None 273, 411
NP_811837.1 BT_2925 None 136, 273
NP_811991.1 BT_3079 None 156, 168
NP_812041.1 BT_3129 None 273, 405
NP_812051.1 BT_3139 None 273, 405
NP_812182.1 BT_3270 None 273, 472
NP_812227.1 BT_3315 None 273, 415
NP_812447.1 BT_3535 None 273, 438
NP_812452.1 BT_3540 None 126, 273
NP_812477.1 BT_3565 None 273, 349
NP_812482.1 BT_3570 None 80, 273
NP_812657.1 BT_3746 None 168, 179
NP_812739.1 BT_3828 None 87, 168
NP_812881.1 BT_3970 None 97, 273
NP_812892.1 BT_3981 None 273, 353
NP_812900.1 BT_3989 None 273, 405
NP_812948.1 BT_4037 None 168, 235
NP_813038.1 nagB None 14, 273
NP_813111.1 BT_4200 None 70, 273
NP_813434.1 BT_4523 None 168, 235
NP_813507.1 BT_4596 None 273, 378
NP_813546.1 BT_4635 None 168, 273
NP_813547.1 BT_4636 None 14, 273
NP_813551.1 BT_4640 None 96, 273
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for NP_813546.1
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend