Organism : Clostridium acetobutylicum | Module List :
Cell division septal protein divIB/FtsQ (NCBI ptt file)
Functional Annotations (1)
|Cell division septal protein||cog/ cog|
Regulation information for CAC2125(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC2125
|Cell division septal protein||cog/ cog|
Module neighborhood information for CAC2125
|Gene||Common Name||Description||Module membership|
|CAC0001||dnaA||DNA replication initiator protein, ATPase (NCBI ptt file)||3, 5|
|CAC0002||dnaN||DNA polymerase III beta subunit (NCBI ptt file)||3, 283|
|CAC0224||CAC0224||Response regulator (CheY-like receiver domain and HTH DNA-binding domain) (NCBI ptt file)||3, 91|
|CAC0294||CAC0294||Magnesium and cobalt transporter (NCBI ptt file)||3, 5|
|CAC0884||CAC0884||CAMP-binding domain (catabolite gene activator) and regulatory subunit of cAMP-dependent protein kinase (NCBI ptt file)||2, 35|
|CAC1195||ligA||DNA ligase (NAD dependent), LigA (NCBI ptt file)||3, 5|
|CAC1241||radc||RadC protein ortholog (NCBI ptt file)||3, 251|
|CAC1243||mreC||Shape-determining protein mreC (NCBI ptt file)||2, 315|
|CAC1244||CAC1244||Predicted membrane protein (NCBI ptt file)||2, 35|
|CAC1245||pbpA||Penicillin-binding protein 2 (NCBI ptt file)||2, 5|
|CAC1279||hemN||Coproporphyrinogen III oxidase (NCBI ptt file)||3, 106|
|CAC1309||CAC1309||Hypothetical protein (NCBI ptt file)||3, 51|
|CAC1437||CAC1437||Diverged AAA-family ATPase containing protein (NCBI ptt file)||2, 35|
|CAC1585||CAC1585||MDR-type permease (NCBI ptt file)||2, 35|
|CAC1628||gyrA||DNA gyrase A subunit (NCBI ptt file)||2, 105|
|CAC1716||CAC1716||Uncharacterized stress-induced protein, YicC family (NCBI ptt file)||3, 251|
|CAC1717||CAC1717||Uncharacterized conserved protein, YLOA ortholog (NCBI ptt file)||3, 91|
|CAC1718||CAC1718||Guanylate kinase, YLOD B.subtilis ortholog (NCBI ptt file)||3, 329|
|CAC1731||CAC1731||Predicted nucleotide-binding protein, YLOS B.subtilis ortholog (NCBI ptt file)||2, 278|
|CAC1736||recG||RecG helicase (NCBI ptt file)||3, 51|
|CAC1793||lexA||P-loop ATPase domain fused to LexA-like protein (NCBI ptt file)||3, 5|
|CAC1794||CAC1794||Predicted permease (NCBI ptt file)||3, 51|
|CAC1818||CAC1818||Conserved membrane protein, possible 4-hydroxybenzoate octaprenyltranferase (NCBI ptt file)||3, 51|
|CAC2032||CAC2032||Hypothetical protein (NCBI ptt file)||3, 258|
|CAC2125||divIB||Cell division septal protein divIB/FtsQ (NCBI ptt file)||2, 3|
|CAC2126||spoVE||Stage V sporulation protein E, FtsW/MrdB/SpoVE family (NCBI ptt file)||2, 229|
|CAC2127||mraY||Phospho-N-acetylmuramoyl-pentapeptide transferase, MraY (NCBI ptt file)||2, 277|
|CAC2128||murF||UDP-N-acetylmuramyl pentapeptide synthase (NCBI ptt file)||2, 229|
|CAC2129||murE||UDP-N-acetylmuramyl tripeptide synthase, MurE (NCBI ptt file)||2, 283|
|CAC2134||CAC2134||Predicted GTPase, YYAF B.subtilis ortholog (NCBI ptt file)||2, 35|
|CAC2138||CAC2138||Exopolyphosphatase (NCBI ptt file)||2, 51|
|CAC2296||CAC2296||Uncharacterized protein, YigZ family (NCBI ptt file)||3, 91|
|CAC2297||CAC2297||Transcriptional regulator of MocR family (DNA-binding HTH domain and aminotransferase domain) (NCBI ptt file)||3, 91|
|CAC2346||CAC2346||Glycosyltransferase (NCBI ptt file)||3, 100|
|CAC2356||pheT||Phenylalanyl-tRNA synthetase (beta subunit) (NCBI ptt file)||2, 35|
|CAC2357||pheS||Phenylalanyl-tRNA synthetase (alpha subunit) (NCBI ptt file)||2, 35|
|CAC2550||CAC2550||Hypothetical protein (NCBI ptt file)||3, 258|
|CAC2674||CAC2674||ATP-dependent superfamily I DNA helicase, PCRA (NCBI ptt file)||3, 98|
|CAC2770||CAC2770||Amino acid transporter (NCBI ptt file)||3, 51|
|CAC2883||CAC2883||Predicted membrane protein (NCBI ptt file)||2, 229|
|CAC3089||CAC3089||Hypothetical protein (NCBI ptt file)||3, 283|
|CAC3091||CAC3091||Fumarate hydratase, subunit A (N-terminal domain of FumA E.coli) class I (NCBI ptt file)||3, 13|
|CAC3308||CAC3308||Glycosyltransferase fused to TPR-repeat domain (NCBI ptt file)||3, 190|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
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