Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU0384 flr

flavoredoxin

CircVis
Functional Annotations (4)
Function System
Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family cog/ cog
electron transport go/ biological_process
FMN binding go/ molecular_function
oxidoreductase activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU0384
(Mouseover regulator name to see its description)

DVU0384 is regulated by 28 influences and regulates 0 modules.
Regulators for DVU0384 flr (28)
Regulator Module Operator
DVU0653
DVU2275
288 combiner
DVU0744
DVU2832
288 combiner
DVU0936 288 tf
DVU0946
DVU2275
288 combiner
DVU1584
DVU2275
288 combiner
DVU1690 288 tf
DVU2036
DVU2275
288 combiner
DVU2036
DVU2582
288 combiner
DVU2547
DVU2086
288 combiner
DVU2588 288 tf
DVU2588
DVU1547
288 combiner
DVU2836 288 tf
DVU3167
DVU3255
288 combiner
DVU3381 288 tf
DVU0653
DVU2275
347 combiner
DVU0744
DVU2690
347 combiner
DVU0744
DVU2832
347 combiner
DVU2275 347 tf
DVU2588
DVU1419
347 combiner
DVU2588
DVU1547
347 combiner
DVU2588
DVU3381
347 combiner
DVU2836 347 tf
DVU3142 347 tf
DVU3167
DVU3255
347 combiner
DVU3186
DVU2275
347 combiner
DVU3255
DVU0936
347 combiner
DVU3255
DVU1584
347 combiner
DVU3255
DVU2633
347 combiner

Warning: DVU0384 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
551 8.60e-01 ATtgccAaaatTGataTaTagcaa
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RegPredict
552 4.10e+00 AccaGaA.GcgccccacggCgcaA
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RegPredict
659 5.00e-01 AtTgaCAaaAttGatAtaTa
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RegPredict
660 1.90e+01 T..CaGAAAg
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU0384

DVU0384 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family cog/ cog
electron transport go/ biological_process
FMN binding go/ molecular_function
oxidoreductase activity go/ molecular_function
Module neighborhood information for DVU0384

DVU0384 has total of 27 gene neighbors in modules 288, 347
Gene neighbors (27)
Gene Common Name Description Module membership
DVU0165 oligopeptide/dipeptide ABC transporter ATP-binding protein 288, 347
DVU0166 oligopeptide/dipeptide ABC transporter ATP-binding protein 288, 347
DVU0167 oligopeptide/dipeptide ABC transporter permease 288, 347
DVU0168 oligopeptide/dipeptide ABC transporter permease 288, 347
DVU0279 sulfate permease family protein 29, 347
DVU0384 flr flavoredoxin 288, 347
DVU0386 amino acid ABC transporter periplasmic amino acid-binding protein 262, 288
DVU0387 His/Glu/Gln/Arg/opine ABC transporter permease 113, 288
DVU0388 amino acid ABC transporter ATP-binding protein 237, 288
DVU0390 glycolate oxidase subunit GlcD 288, 347
DVU0548 high-affinity branched-chain amino acid ABC transporter permease 126, 347
DVU0549 high-affinity branched-chain amino acid ABC transporter permease 126, 347
DVU0550 high-affinity branched-chain amino acid ABC transporter ATP binding protein 126, 347
DVU0551 high-affinity branched-chain amino acid ABC transporter ATP-binding protein 282, 347
DVU0713 branched-chain amino acid ABC transporter permease 303, 347
DVU0714 branched-chain amino acid ABC transporter permease 331, 347
DVU1038 hisA 1-(5-phosphoribosyl)-5- 146, 288
DVU1089 alaS alanyl-tRNA synthetase 288, 323
DVU1245 ABC transporter ATP-binding protein 78, 347
DVU1260 outer membrane protein P1 288, 344
DVU1291 hypothetical protein DVU1291 282, 347
DVU1351 MarC membrane protein 187, 288
DVU2341 amino acid ABC transporter permease 78, 347
DVUA0069 GtrA family protein, selenocysteine-containing 288, 347
DVUA0070 hypothetical protein DVUA0070 288, 347
DVUA0074 sulfotransferase family protein 98, 288
DVUA0076 ABC transporter ATP-binding protein 163, 288
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU0384
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend