Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU1978

Na+/H+ antiporter family protein

CircVis
Functional Annotations (3)
Function System
Na+/H+ antiporter cog/ cog
amino acid transmembrane transporter activity go/ molecular_function
integral to membrane go/ cellular_component
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU1978
(Mouseover regulator name to see its description)

DVU1978 is regulated by 19 influences and regulates 0 modules.
Regulators for DVU1978 (19)
Regulator Module Operator
DVU0653 294 tf
DVU0682
DVU1949
294 combiner
DVU0854
DVU0682
294 combiner
DVU0854
DVU2275
294 combiner
DVU1584
DVU0653
294 combiner
DVU2394
DVU2832
294 combiner
DVU2423
DVU2832
294 combiner
DVU3167 294 tf
DVU0309
DVU0653
223 combiner
DVU0653 223 tf
DVU1561
DVU1964
223 combiner
DVU1788
DVU2275
223 combiner
DVU1949 223 tf
DVU2036
DVU2275
223 combiner
DVU2275 223 tf
DVU2557
DVU2195
223 combiner
DVU2909
DVU0653
223 combiner
DVU2909
DVU2275
223 combiner
DVU3167 223 tf

Warning: DVU1978 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
425 1.20e-02 GggcgcAaGgC
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RegPredict
426 8.40e+03 gGCaTcGtATcgAcGaatCaC
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RegPredict
563 9.90e-01 a.gtctTaTatttcTcc.T.ttat
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RegPredict
564 5.40e+00 cCtgAAAaaCa
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU1978

DVU1978 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Na+/H+ antiporter cog/ cog
amino acid transmembrane transporter activity go/ molecular_function
integral to membrane go/ cellular_component
Module neighborhood information for DVU1978

DVU1978 has total of 46 gene neighbors in modules 223, 294
Gene neighbors (46)
Gene Common Name Description Module membership
DVU0135 hypothetical protein DVU0135 223, 278
DVU0136 hypothetical protein DVU0136 44, 223
DVU0141 M50 family peptidase 9, 223
DVU0323 folD bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 9, 223
DVU0414 NADP-dependent malic enzyme-like protein 176, 223
DVU0660 phosphodiesterase 223, 278
DVU0724 sodium/alanine symporter family protein 223, 278
DVU0726 tgt queuine tRNA-ribosyltransferase 176, 223
DVU0785 rodA rod shape-determining protein RodA 75, 294
DVU0795 purC phosphoribosylaminoimidazole-succinocarboxamide synthase 176, 223
DVU0796 hisD histidinol dehydrogenase 113, 223
DVU1029 hisC histidinol-phosphate aminotransferase 9, 223
DVU1060 glycosyl transferase group 1 family protein 223, 278
DVU1091 hypothetical protein DVU1091 57, 223
DVU1214 dolichyl-phosphate-mannose-protein mannosyltransferase family protein 65, 294
DVU1220 nitroreductase family protein 223, 323
DVU1281 hypothetical protein DVU1281 95, 294
DVU1540 purU formyltetrahydrofolate deformylase 9, 223
DVU1580 ribose 5-phosphate isomerase 57, 294
DVU1581 hypothetical protein DVU1581 141, 294
DVU1583 hypothetical protein 282, 294
DVU1585 vitamin B12-dependent methionine synthase 12, 294
DVU1586 thioredoxin family protein 292, 294
DVU1588 hpt hypoxanthine phosphoribosyltransferase 215, 294
DVU1589 hypothetical protein DVU1589 12, 294
DVU1693 gltX-1 glutamyl-tRNA synthetase 223, 275
DVU1769 hydA periplasmic 176, 294
DVU1770 hydB periplasmic 137, 294
DVU1827 diaminopimelate aminotransferase 223, 258
DVU1866 hypothetical protein DVU1866 292, 294
DVU1942 DAK2 and DegV domain-containing protein 223, 228
DVU1978 Na+/H+ antiporter family protein 223, 294
DVU2024 hypothetical protein DVU2024 273, 294
DVU2026 hypothetical protein DVU2026 273, 294
DVU2031 hypothetical protein DVU2031 273, 294
DVU2037 cobS protein 273, 294
DVU2055 metG methionyl-tRNA synthetase 30, 223
DVU2210 hypothetical protein 180, 223
DVU2436 hypothetical protein DVU2436 223, 278
DVU2471 oxidoreductase, selenocysteine-containing 63, 223
DVU2493 iron-sulfur cluster-binding protein 185, 223
DVU2552 gltX glutamyl-tRNA synthetase 113, 223
DVU2892 GTP cyclohydrolase 180, 223
DVU3100 biopolymer ExbD/TolR family transporter 44, 294
DVU3208 membrane protein 62, 223
DVU3389 topA DNA topoisomerase I 223, 228
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU1978
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend