Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU2335

hypothetical protein DVU2335

CircVis
Functional Annotations (3)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
carbohydrate metabolic process go/ biological_process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU2335
(Mouseover regulator name to see its description)

DVU2335 is regulated by 23 influences and regulates 0 modules.
Regulators for DVU2335 (23)
Regulator Module Operator
DVU1419 258 tf
DVU1547 258 tf
DVU1547
DVU3381
258 combiner
DVU1788
DVU2275
258 combiner
DVU1949 258 tf
DVU2195 258 tf
DVU2275 258 tf
DVU2275
DVU2582
258 combiner
DVU2423 258 tf
DVU2547
DVU1142
258 combiner
DVU2547
DVU2394
258 combiner
DVU2909
DVU2275
258 combiner
DVU0653
DVU2275
306 combiner
DVU1419 306 tf
DVU1547
DVUA0024
306 combiner
DVU1949 306 tf
DVU2036
DVU2275
306 combiner
DVU2423
DVU2832
306 combiner
DVU2423
DVU3381
306 combiner
DVU2547
DVU2588
306 combiner
DVU2547
DVU2832
306 combiner
DVU2547
DVU3142
306 combiner
DVU3381 306 tf

Warning: DVU2335 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
491 2.30e+04 TcggCaTCaaTCctgTCaga
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RegPredict
492 4.60e+03 acAaCAcaCAcCaTC
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RegPredict
585 1.50e+02 TaattaA.A.AAggcatGCaAcgC
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RegPredict
586 1.40e+02 GTtGCgTg
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU2335

DVU2335 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
carbohydrate metabolic process go/ biological_process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds go/ molecular_function
Module neighborhood information for DVU2335

DVU2335 has total of 51 gene neighbors in modules 258, 306
Gene neighbors (51)
Gene Common Name Description Module membership
DVU0187 GGDEF domain-containing protein 258, 304
DVU0704 lepB signal peptidase I 230, 258
DVU0836 trmD tRNA (guanine-N1)-methyltransferase 188, 306
DVU0867 aromatic amino acid decarboxylase 28, 306
DVU0931 thiD phosphomethylpyrimidine kinase 30, 306
DVU0956 rpsF 30S ribosomal protein S6 151, 306
DVU0966 amino acid ABC transporter periplasmic amino acid-binding protein 146, 306
DVU1046 hypothetical protein DVU1046 195, 306
DVU1049 ABC transporter ATP-binding protein 251, 306
DVU1061 glycosyl transferase group 1 family protein 228, 258
DVU1069 branched chain amino acid ABC transporter permease 221, 306
DVU1176 hypothetical protein DVU1176 228, 258
DVU1217 MATE efflux family protein 160, 258
DVU1237 His/Glu/Gln/Arg/opine ABC transporter permease 166, 306
DVU1249 fabD malonyl CoA-ACP transacylase 64, 306
DVU1254 hypothetical protein DVU1254 96, 258
DVU1255 Sua5/YciO/YrdC/YwlC family protein 84, 258
DVU1270 twitching motility protein 166, 306
DVU1274 hypothetical protein DVU1274 64, 306
DVU1287 reductase, iron-sulfur binding subunit 151, 306
DVU1288 cytochrome c family protein 151, 306
DVU1289 reductase, iron-sulfur binding subunit 151, 306
DVU1386 hypothetical protein DVU1386 258, 291
DVU1387 hypothetical protein DVU1387 121, 258
DVU1411 thiC thiamine biosynthesis protein ThiC 139, 306
DVU1746 C-5 cytosine-specific DNA methylase family protein 306, 331
DVU1807 nadC nicotinate-nucleotide pyrophosphorylase 228, 258
DVU1808 nadA quinolinate synthetase 75, 258
DVU1826 hypothetical protein DVU1826 27, 258
DVU1827 diaminopimelate aminotransferase 223, 258
DVU1828 gidA tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 258, 282
DVU1848 hypothetical protein DVU1848 126, 306
DVU1900 hypothetical protein DVU1900 12, 306
DVU1936 phosphonate ABC transporter ATP-binding protein 75, 306
DVU2053 hypothetical protein DVU2053 30, 258
DVU2113 xanthine/uracil permease 228, 306
DVU2259 hypothetical protein DVU2259 228, 258
DVU2260 rrmJ ribosomal RNA large subunit methyltransferase J 228, 258
DVU2285 L-lactate permease family protein 145, 306
DVU2335 hypothetical protein DVU2335 258, 306
DVU2355 trmH tRNA (guanosine-2'-O-)-methyltransferase 221, 258
DVU2376 lysS lysyl-tRNA synthetase 228, 258
DVU2533 pheT phenylalanyl-tRNA synthetase subunit beta 186, 306
DVU2535 rplT 50S ribosomal protein L20 186, 258
DVU2553 NifU family protein 166, 258
DVU2927 rplL 50S ribosomal protein L7/L12 151, 306
DVU2928 rpoB DNA-directed RNA polymerase subunit beta 151, 306
DVU3053 hypothetical protein DVU3053 228, 258
DVU3059 ftsY signal recognition particle-docking protein FtsY 228, 258
DVU3159 gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 137, 258
DVU3253 phenylacetate-coenzyme A ligase 230, 306
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU2335
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend