Organism : Halobacterium salinarum NRC-1 | Module List :
Regulation information for VNG2414H(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 6 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Module neighborhood information for VNG2414H
|Gene||Common Name||Description||Module membership|
|VNG0139H||hypothetical protein VNG0139H||17, 18, 30, 196|
|VNG0140H||hypothetical protein VNG0140H||18, 26, 30, 239|
|VNG0512G||ppe||DNA double-strand break repair protein||18, 121, 177, 196|
|VNG0869G||tfbD||transcription initiation factor IIB||18, 91, 95, 212|
|VNG1270H||hypothetical protein VNG1270H||18, 30, 37, 42|
|VNG1271H||hypothetical protein VNG1271H||18, 30, 37|
|VNG1646G||trpG1||anthranilate synthase subunit beta||30, 48, 64, 87|
|VNG1647G||trpE1||anthranilate synthase component I||48, 64|
|VNG1648G||trpF||hypothetical protein VNG1648G||4, 5, 28, 30, 48, 64, 87|
|VNG1649G||trpD||anthranilate phosphoribosyltransferase||28, 30, 48, 64, 87, 92|
|VNG1734H||hypothetical protein VNG1734H||64, 74|
|VNG1831H||hypothetical protein VNG1831H||64|
|VNG1890H||hypothetical protein VNG1890H||18, 105, 167|
|VNG1952H||hypothetical protein VNG1952H||18, 28, 30, 42, 68, 80, 91, 108, 121, 135|
|VNG1953C||hypothetical protein VNG1953C||13, 18, 30, 34, 42, 80, 91, 108, 115, 121|
|VNG1956H||hypothetical protein VNG1956H||18, 30, 34, 42, 80, 91, 108, 115, 121|
|VNG1963H||hypothetical protein VNG1963H||38|
|VNG2024H||hypothetical protein VNG2024H||38|
|VNG2174H||hypothetical protein VNG2174H||34, 38, 297|
|VNG2230H||hypothetical protein VNG2230H||64|
|VNG2231C||hypothetical protein VNG2231C||64|
|VNG2317G||cbiO1||cobalt transport ATP-binding protein||38, 48, 178|
|VNG2414H||hypothetical protein VNG2414H||18, 38, 64|
|VNG2444C||hypothetical protein VNG2444C||17, 28, 31, 38, 173|
|VNG2466C||None||13, 31, 64, 70, 166|
|VNG5047H||None||15, 18, 63|
|VNG5120H||None||18, 37, 198|
|VNG6150G||orc1||orc / cell division control protein 6||4, 13, 38, 142, 189|
|VNG6157H||hypothetical protein VNG6157H||18|
|VNG6160H||hypothetical protein VNG6160H||38|
|VNG6168H||hypothetical protein VNG6168H||38, 42|
|VNG6176G||kdpA||potassium-transporting ATPase subunit A||5, 15, 18, 21, 26, 28, 31, 47, 51, 53, 62, 63, 69, 70, 72, 74, 177, 279|
|VNG6178G||kdpC||potassium-transporting ATPase C chain||5, 15, 18, 26, 28, 31, 47, 51, 53, 62, 63, 69, 70, 72, 74, 177, 279|
|VNG6183C||hypothetical protein VNG6183C||15, 18, 213|
|VNG6184G||cat4||cationic amino acid transporter||15, 18, 213|
|VNG6185H||hypothetical protein VNG6185H||15, 18, 213|
|VNG6186H||hypothetical protein VNG6186H||15, 18, 213|
|VNG6191H||hypothetical protein VNG6191H||17, 30, 34, 38, 41, 44, 80, 91|
|VNG6193H||hypothetical protein VNG6193H||17, 32, 34, 38, 41, 42, 44, 80|
|VNG6197H||hypothetical protein VNG6197H||38, 108|
|VNG6224H||hypothetical protein VNG6224H||18, 91|
|VNG6229G||gvpL2||GvpL protein, cluster B||38, 141, 188|
|VNG6258C||hypothetical protein VNG6258C||18, 30, 108|
|VNG6291H||hypothetical protein VNG6291H||38|
|VNG6292C||hypothetical protein VNG6292C||17, 18, 30, 89|
|VNG6396H||hypothetical protein VNG6396H||38|
|VNG6397H||hypothetical protein VNG6397H||38|
|VNG6400H||hypothetical protein VNG6400H||18, 30, 80, 133, 245, 290|
|VNG6418H||hypothetical protein VNG6418H||13, 18, 21, 41, 60, 281|
|VNG6427H||hypothetical protein VNG6427H||17, 18, 30, 62, 74, 89, 107|
|VNG6431H||hypothetical protein VNG6431H||17, 26, 30, 38, 178|
|VNG6432H||hypothetical protein VNG6432H||17, 26, 31, 38, 106, 243|
|VNG7011||repH||plasmid replication protein RepH||17, 18, 30, 107, 122, 224, 287|
|VNG7109||hypothetical protein VNG7109||4, 18, 38, 91|
|VNG7110||hypothetical protein VNG7110||18, 38, 91, 147|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
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Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
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