Organism : Methanococcus maripaludis S2 | Module List :
Regulation information for MMP0194(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 6 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for MMP0194
Module neighborhood information for MMP0194
|Gene||Common Name||Description||Module membership|
|MMP0029||hypothetical protein MMP0029||108, 131|
|MMP0042||H/ACA RNA-protein complex component Gar1||19, 108|
|MMP0174||HD phosphohydrolase family protein||42, 131|
|MMP0194||hypothetical protein MMP0194||31, 108, 131|
|MMP0195||hypothetical protein MMP0195||6, 31|
|MMP0198||ABC-type iron(III) transport system ATP binding protein||26, 31, 82|
|MMP0200||fmdE||molybdenum containing formylmethanofuran dehydrogenase subunit E||53, 131|
|MMP0208||hypothetical protein MMP0208||26, 31, 42, 82|
|MMP0335||hypothetical protein MMP0335||108, 156|
|MMP0375||radical SAM domain-containing protein||31, 45|
|MMP0423||hypothetical protein MMP0423||72, 131|
|MMP0435||hypothetical protein MMP0435||31, 72|
|MMP0436||rimK||RimK domain-containing protein||6, 31, 42, 72, 82, 110|
|MMP0437||hypothetical protein MMP0437||6, 31, 42, 53, 82|
|MMP0461||hypothetical protein MMP0461||6, 131|
|MMP0462||hypothetical protein MMP0462||53, 131|
|MMP0463||hypothetical protein MMP0463||45, 131|
|MMP0473||hypothetical protein MMP0473||31, 42|
|MMP0474||hypothetical protein MMP0474||31, 131|
|MMP0475||hypothetical protein MMP0475||26, 31, 45, 72, 82, 151|
|MMP0484||sodium/hydrogen exchanger||31, 72, 127, 131, 161|
|MMP0495||hypothetical protein MMP0495||31, 42, 127, 155|
|MMP0501||hypothetical protein MMP0501||31, 82|
|MMP0519||hypothetical protein MMP0519||6, 31, 161|
|MMP0542||hypothetical protein MMP0542||108, 156|
|MMP0628||TOBE domain-containing protein||108, 123, 156|
|MMP0634||hypothetical protein MMP0634||43, 108|
|MMP0635||ABC transporter ATPase||75, 108|
|MMP0652||hypothetical protein MMP0652||131, 166|
|MMP0673||hypothetical protein MMP0673||5, 31|
|MMP0711||corA||magnesium/cobalt transporter CorA||43, 108|
|MMP0739||Asp/Glu racemase:aspartate racemase||45, 131|
|MMP0740||purine NTPase||6, 26, 31, 72, 82|
|MMP0778||hypothetical protein MMP0778||31, 72|
|MMP0779||hypothetical protein MMP0779||31, 72|
|MMP0782||hypothetical protein MMP0782||31, 53, 72, 127, 155, 161|
|MMP0801||hypothetical protein MMP0801||31, 72|
|MMP0802||Iron-containing alcohol dehydrogenase||31, 53|
|MMP0818||frcG||coenzyme F420-reducing hydrogenase subunit gamma||9, 131|
|MMP0819||frcD||coenzyme F420-reducing hydrogenase subunit delta||9, 131|
|MMP0820||frcA||coenzyme F420-reducing hydrogenase subunit alpha||123, 131|
|MMP0826||hypothetical protein MMP0826||31, 154|
|MMP0837||ribonuclease H||53, 131|
|MMP0847||hypothetical protein MMP0847||6, 131|
|MMP0964||hypothetical protein MMP0964||43, 108|
|MMP0988||RNA methyltransferase-like protein||108, 131|
|MMP0998||hypothetical protein MMP0998||31, 131|
|MMP1015||transcription factor CBF/NF-Y||72, 108|
|MMP1088||group 1 glycosyl transferase||31, 117|
|MMP1110||hypothetical protein MMP1110||31, 146|
|MMP1156||carboxymuconolactone decarboxylase||74, 84, 108, 123|
|MMP1162||beta-lactamase domain-containing protein||75, 108|
|MMP1172||DNA protection protein DPS||6, 31, 82|
|MMP1225||amino acid ABC-type transporter-like protein||30, 131|
|MMP1347||HMmB||histone B||31, 123|
|MMP1385||fruB||coenzyme F420-reducing hydrogenase subunit beta||108, 113|
|MMP1486||mechanosensitive ion channel MscS||108, 131|
|MMP1529||type 11 methyltransferase||45, 131|
|MMP1596||hypothetical protein MMP1596||31, 42, 155|
|MMP1660||hypothetical protein MMP1660||42, 108, 123, 131|
|MMP1661||hypothetical protein MMP1661||123, 131|
|MMP1685||hypothetical protein MMP1685||123, 131|
|MMP1703||hypothetical protein MMP1703||43, 108|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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