Organism : Methanococcus maripaludis S2 | Module List :
MMP0052

putative CBS domain-containing signal transduction protein

CircVis
Functional Annotations (6)
Function System
Predicted transcriptional regulator, contains C-terminal CBS domains cog/ cog
catalytic activity go/ molecular_function
voltage-gated chloride channel activity go/ molecular_function
chloride transport go/ biological_process
metabolic process go/ biological_process
membrane go/ cellular_component
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for MMP0052
(Mouseover regulator name to see its description)

MMP0052 is regulated by 6 influences and regulates 49 modules.
Regulators for MMP0052 (6)
Regulator Module Operator
MMP0527
MMP1210
117 combiner
MMP0568 117 tf
MMP1065 117 tf
MMP1065
MMP1210
117 combiner
MMP1065 13 tf
MMP1447 13 tf

Warning: MMP0052 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
687 9.70e+00 tCgcgGg.aCT
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688 1.90e+04 GGatCTtGGGG
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889 2.10e+01 TTTcttctagaaTATcccgGgtGA
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890 3.40e+01 TTTTCcagatTttg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for MMP0052

MMP0052 is enriched for 6 functions in 3 categories.
Enrichment Table (6)
Function System
Predicted transcriptional regulator, contains C-terminal CBS domains cog/ cog
catalytic activity go/ molecular_function
voltage-gated chloride channel activity go/ molecular_function
chloride transport go/ biological_process
metabolic process go/ biological_process
membrane go/ cellular_component
Module neighborhood information for MMP0052

MMP0052 has total of 52 gene neighbors in modules 13, 117
Gene neighbors (52)
Gene Common Name Description Module membership
Antisense_23 None 1, 117
MMP0022 hypothetical protein MMP0022 13, 66
MMP0023 hypothetical protein MMP0023 13, 66
MMP0030 MCM family DNA replication protein 106, 117
MMP0052 putative CBS domain-containing signal transduction protein 13, 117
MMP0154 hypothetical protein MMP0154 1, 13
MMP0177 hypothetical protein MMP0177 83, 117, 152
MMP0225 gldA glycerol dehydrogenase 117, 142
MMP0226 ExsB family transcriptional regulator 13, 117
MMP0289 hypD hydrogenase expression/formation protein HypD 12, 117
MMP0336 hjc Holliday junction resolvase 13, 94
MMP0337 hypothetical protein MMP0337 13, 94
MMP0420 CBS domain-containing protein 13, 106
MMP0421 hypothetical protein MMP0421 13, 83
MMP0422 hypothetical protein MMP0422 13, 83
MMP0439 pyrD dihydroorotate dehydrogenase 1B 117, 119
MMP0449 ferredoxin 13, 70
MMP0633 rubrerythrin 13, 50
MMP0686 fructose-bisphosphate aldolase 13, 121
MMP0687 tpiA triosephosphate isomerase 8, 13
MMP0709 hypothetical protein MMP0709 13, 156
MMP0788 hypothetical protein MMP0788 58, 117
MMP0849 L-lysine/ homoserine-homoserine lactone exporter family protein 95, 117
MMP0992 hypothetical protein MMP0992 55, 117
MMP1016 putative CBS domain-containing signal transduction protein 13, 123
MMP1058 hypothetical protein MMP1058 13, 83
MMP1088 group 1 glycosyl transferase 31, 117
MMP1118 hypothetical protein MMP1118 83, 117
MMP1235 moaE molybdopterin biosynthesis MoaE 49, 55, 106, 117, 150
MMP1236 hypothetical protein MMP1236 22, 55, 117, 142, 152
MMP1241 hypothetical protein MMP1241 1, 55, 94, 117
MMP1330 hydrogenase assembly chaperone hypC/hupF 100, 117
MMP1358 ferredoxin 13, 21
MMP1397 smc1 structural maintenance of chromosome protein 13, 83
MMP1447 Cro repressor family protein 22, 117
MMP1452 ehaE hypothetical protein MMP1452 22, 117
MMP1453 ehaF hypothetical protein MMP1453 22, 117
MMP1454 ehaG hypothetical protein MMP1454 66, 117, 133
MMP1456 ehaI hypothetical protein MMP1456 66, 117, 133
MMP1459 ehaL hypothetical protein MMP1459 66, 117, 133
MMP1461 ehaN energy conserving hydrogenase A small subunit 117, 133
MMP1533 hypothetical protein MMP1533 13, 123
MMP1534 hypothetical protein MMP1534 13, 123
MMP1606 flavoprotein:DNA/pantothenate metabolism flavoprotein 1, 13, 49
MMP1613 ssh10b_1 DNA/RNA-binding protein albA 13, 50
MMP1619 molybdenum cofactor biosynthesis protein MoeA 117, 152
MMP1635 redox-active disulfide protein 1 13, 50
MMP1637 hypothetical protein MMP1637 13, 19
MMP1662 cbiF precorrin-4 C11-methyltransferase 66, 117
MMP1665 HEAT domain-containing protein 66, 117
MMP1679 hypothetical protein MMP1679 117, 151
Unanno_49 None 95, 117
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for MMP0052
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend