Systems-level analysis of innate immunity.

Publication Type:

Journal Article

Source:

Annu Rev Immunol, Volume 32, p.547-77 (2014)

Keywords:

Animals, Communicable Disease Control, Communicable Diseases, Humans, Immunity, Innate, Systems Biology, Vaccines

Abstract:

<p>Systems-level analysis of biological processes strives to comprehensively and quantitatively evaluate the interactions between the relevant molecular components over time, thereby enabling development of models that can be employed to ultimately predict behavior. Rapid development in measurement technologies (omics), when combined with the accessible nature of the cellular constituents themselves, is allowing the field of innate immunity to take significant strides toward this lofty goal. In this review, we survey exciting results derived from systems biology analyses of the immune system, ranging from gene regulatory networks to influenza pathogenesis and systems vaccinology.</p>