TFOE Searchable Data File

To investigate the MTB transcriptional landscape in a systematic manner, we developed a high-throughput approach to identify the genes controlled by nearly all predicted MTB TFs. We individually cloned and conditionally overexpressed 206 MTB TFs to induce the regulatory signature of each one. Using this approach we identified the sets of genes affected by TF overexpression (TFOE) and assembled them into an easily searchable map of transcriptional regulation in MTB.

Accessing large datasets like the TFOE expression data can be difficult when the data spreads over thousands of genes and hundreds of regulators. To address the difficulties usually associated with accessing large data sets, we have designed a simple Excel spreadsheet for querying TFOE data to find regulators of specific genes or sets of genes. (Rustad et al. Genome Biol. 2014)

Last update: 29/02/2015

TFOE Expression Data Records

Title Gene BioProject GEO Series Platform Accession Sample Method Sample Type References Release Date Repository
TFOE_8468_3911
RNA polymerase sigma-70 factor, ECF subfamily
PRJNA254351 GSE59086 GPL14824 GSM1427062 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_8127_3911
RNA polymerase sigma-70 factor, ECF subfamily
PRJNA254351 GSE59086 GPL14824 GSM1427061 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_2756_3911
RNA polymerase sigma-70 factor, ECF subfamily
PRJNA254351 GSE59086 GPL14824 GSM1427060 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_7945_3862c_B
Transcriptional regulator WhiB-like WhiB6
PRJNA254351 GSE59086 GPL14824 GSM1427059 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_6830_3862c
Transcriptional regulator WhiB-like WhiB6
PRJNA254351 GSE59086 GPL14824 GSM1427058 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_4985_3862c_A
Transcriptional regulator WhiB-like WhiB6
PRJNA254351 GSE59086 GPL14824 GSM1427057 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_2656_3862c
Transcriptional regulator WhiB-like WhiB6
PRJNA254351 GSE59086 GPL14824 GSM1427056 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_9032_3855
Transcriptional repressor EthR, TetR family
PRJNA254351 GSE59086 GPL14824 GSM1427055 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_3194_3855
Transcriptional repressor EthR, TetR family
PRJNA254351 GSE59086 GPL14824 GSM1427054 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_1176_3855
Transcriptional repressor EthR, TetR family
PRJNA254351 GSE59086 GPL14824 GSM1427053 Tiling Array RNA 25232098 4-Jul-14 GEO