Data Center

Welcome to MTB Portal Data Center. This section provides quick access to data files hosted at the portal. Each panel provides overview of the corresponding data files. You can access to more data by clicking on "more" button or to the panel header.

OTB supplement: Systems analysis of TB progression in RhCMV/MTB vaccinated NHP. Whole blood multi-omics profiling of MTB-challenged Rhesus macaques after vaccination with RhCMV and/or BCG.

Currently, data files in this section are private and download link will be available after login.

Title Body Release Date Sample Type
RhCMV-TB Metabolomics Data

Whole blood metabolomics profiling of MTB-challenged Rhesus macaques after vaccination with RhCMV and/or BCG. 

Each row is a metabolite and each column is a monkey at the defined time point

2018 Metabolomics
RhCMV-TB Proteomics Data

Whole blood proteomics profiling of MTB-challenged Rhesus macaques after vaccination with RhCMV and/or BCG

2018 Protein
RhCMV-TB Transcriptomic Data

Whole blood transcriptomes of MTB-challenged Rhesus macaques after vaccination with RhCMV and/or BCG

Log2 standardized counts (using edgeR) are reported. Each row is a gene and each column is a monkey at the defined time point.

2018 RNA
RhCMV-TB Meta Data

Whole blood omics profiling of MTB-challenged Rhesus macaques after vaccination with RhCMV and/or BCG

Meta-data information is listed. Columns are the monkey ID, which trial the monkey is from, the disease score after challenge, and the vaccination group.

2018 Meta-data
Quantitative Proteomics Data
Publication: 
Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network.

To investigate the MTB transcriptional landscape in a systematic manner, we developed a high-throughput approach to identify the genes controlled by nearly all predicted MTB TFs. We individually cloned and conditionally overexpressed 206 MTB TFs to induce the regulatory signature of each one. Using this approach we identified the sets of genes affected by TF overexpression (TFOE) and assembled them into an easily searchable map of transcriptional regulation in MTB.

Accessing large datasets like the TFOE expression data can be difficult when the data spreads over thousands of genes and hundreds of regulators. To address the difficulties usually associated with accessing large data sets, we have designed a simple Excel spreadsheet for querying TFOE data to find regulators of specific genes or sets of genes. (Rustad et al. Genome Biol. 2014)

Last update: 29/02/2015
BioProject:

Whole blood metabolomics profiling of MTB-challenged Rhesus macaques after vaccination with RhCMV and/or BCG. 

Each row is a metabolite and each column is a monkey at the defined time point

Title Gene BioProject GEO Series Platform Accession Sample Method Sample Type References Release Date Repository Contact
RhCMV-TB Metabolomics Data Metabolomics 2018
RhCMV-TB Proteomics Data Protein 2018
RhCMV-TB Transcriptomic Data RNA-seq RNA 2018
RhCMV-TB Meta Data in progress NA NA Meta-data in preparation 2018 in progress
TFOE_8468_3911
RNA polymerase sigma-70 factor, ECF subfamily
PRJNA254351 GSE59086 GPL14824 GSM1427062 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_8127_3911
RNA polymerase sigma-70 factor, ECF subfamily
PRJNA254351 GSE59086 GPL14824 GSM1427061 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_2756_3911
RNA polymerase sigma-70 factor, ECF subfamily
PRJNA254351 GSE59086 GPL14824 GSM1427060 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_7945_3862c_B
Transcriptional regulator WhiB-like WhiB6
PRJNA254351 GSE59086 GPL14824 GSM1427059 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_6830_3862c
Transcriptional regulator WhiB-like WhiB6
PRJNA254351 GSE59086 GPL14824 GSM1427058 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_4985_3862c_A
Transcriptional regulator WhiB-like WhiB6
PRJNA254351 GSE59086 GPL14824 GSM1427057 Tiling Array RNA 25232098 4-Jul-14 GEO