Organism : Rhodobacter sphaeroides 2.4.1 | Module List :
Regulation information for RSP_1144(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for RSP_1144
Module neighborhood information for RSP_1144
|Gene||Common Name||Description||Module membership|
|RSP_0030||RSP_0030||PAS sensor diguanylatecyclase/phosphodiesterase (NCBI)||60, 245|
|RSP_0041||RSP_0041||hypothetical protein (NCBI)||60, 245|
|RSP_0371||RSP_0371||ABC basic amino acid transporter, ATPase subunit (NCBI)||67, 114|
|RSP_0372||RSP_0372||ABC basic amino acid transporter, solute-binding protein (NCBI)||67, 114|
|RSP_0375||RSP_0375||probable glutamine synthetase (NCBI)||65, 67|
|RSP_0463||RSP_0463||cation efflux transporter, CDF family (NCBI)||22, 67|
|RSP_0499||hupD||HycI, hydrogenase maturation protease (NCBI)||199, 245|
|RSP_0500||RSP_0500||putative HupF/HypC hydrogenase protein (NCBI)||199, 245|
|RSP_0501||hupG||HupG hydrogenase expression/formation protein (NCBI)||199, 245|
|RSP_0502||hupH||HupH hydrogenase expression/formation protein (NCBI)||199, 245|
|RSP_0503||hupJ||HupJ, contains rubredoxin domain (NCBI)||199, 245|
|RSP_0504||hupK||HupK (NCBI)||199, 245|
|RSP_0505||hypA||Hydrogenase expression/synthesis, HypA family (NCBI)||199, 245|
|RSP_0506||hypB||NI2+-binding GTPase protein HypB (NCBI)||199, 245|
|RSP_0507||RSP_0507||HupR response regulator (NCBI)||199, 245|
|RSP_0508||hypC||Hydrogenase expression/formation protein HypC (NCBI)||199, 245|
|RSP_0509||hypD||hydrogenase isoenzymes formation protein HypD (NCBI)||199, 245|
|RSP_0510||hypE||hydrogenase expression/formation protein HypE (NCBI)||199, 245|
|RSP_0513||RSP_0513||hypothetical protein (NCBI)||60, 245|
|RSP_0565||RSP_0565||putative phosphatidylcholine synthase (NCBI)||67, 108|
|RSP_0804||DppD||ABC dipeptide transporter, ATPase subunit DppD (NCBI)||67, 114|
|RSP_0805||DppC||ABC dipeptide transporter, inner membrane subunit DppC (NCBI)||57, 67|
|RSP_0809||RSP_0809||hypothetical protein (NCBI)||67, 207|
|RSP_0860||RSP_0860||hypothetical protein (NCBI)||245, 380|
|RSP_0861||RSP_0861||putative transmembrane hypothetical protein (NCBI)||60, 245|
|RSP_0973||RSP_0973||MaoC family protein (NCBI)||67, 118|
|RSP_1144||Gst||Glutathione S-transferase (NCBI)||67, 245|
|RSP_1145||RSP_1145||Peptidoglycan transglycosylase (NCBI)||67, 254|
|RSP_1186||RSP_1186||hypothetical protein (NCBI)||59, 67|
|RSP_1340||RSP_1340||Enoyl-CoA hydratase/isomerase (NCBI)||67, 384|
|RSP_1627||RSP_1627||Putative N-6 adenine-specific DNA methylase (NCBI)||245, 379|
|RSP_1853||TrkH2||potassium uptake transporter, transmembrane component, TrkH (NCBI)||29, 67|
|RSP_1854||trkH3||potassium uptake transporter, transmembrane component, TrkH (NCBI)||67, 288|
|RSP_1901||RSP_1901||Hypothetical protein with TPR repeat (NCBI)||91, 245|
|RSP_2171||metR||transcriptional regulator, LysR family (NCBI)||67, 259|
|RSP_2205||RSP_2205||hypothetical protein (NCBI)||67, 234|
|RSP_2206||RSP_2206||hypothetical protein (NCBI)||67, 234|
|RSP_2207||deoD||purine nucleoside phosphorylase (NCBI)||67, 110|
|RSP_2208||RSP_2208||ABC sugar transporter, inner membrane subunit (NCBI)||67, 174|
|RSP_2209||RSP_2209||ABC sugar transporter, inner membrane subunit (NCBI)||67, 174|
|RSP_2211||RSP_2211||ABC transporter, periplasmic substrate-binding protein (NCBI)||67, 70|
|RSP_2332||RSP_2332||hypothetical protein (NCBI)||67, 72|
|RSP_2541||tatC||twin-arginine translocation system protein, TatC (NCBI)||67, 291|
|RSP_2730||RSP_2730||Transcriptional regulator, ArsR family (NCBI)||67, 95|
|RSP_2939||RSP_2939||Predicted transcriptional regulator containing the HTH domain (NCBI)||67, 174|
|RSP_3216||RSP_3216||putative DNA repair exonuclease (NCBI)||20, 67|
|RSP_3253||RSP_3253||Predicted acetamidase / formamidase (NCBI)||157, 245|
|RSP_3255||RSP_3255||ABC peptide transporter, periplasmic binding protein (NCBI)||157, 245|
|RSP_3313||RSP_3313||possible phage integrase family protein (NCBI)||67, 112|
|RSP_3330||sac1||Putative sodium/sulfate transporter, DASS family (NCBI)||67, 375|
|RSP_3367||RSP_3367||hypothetical protein (NCBI)||67, 145|
|RSP_3769||RSP_3769||Adenine-specific DNA methyltransferase (NCBI)||245, 379|
|RSP_3808||RSP_3808||hypothetical protein (NCBI)||67, 114|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
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Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
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