Organism : Rhodobacter sphaeroides 2.4.1 | Module List :
RSP_2952

BolA-like protein (NCBI)

CircVis
Functional Annotations (1)
Function System
Stress-induced morphogen (activity unknown) cog/ cog
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for RSP_2952
(Mouseover regulator name to see its description)

RSP_2952 is regulated by 26 influences and regulates 0 modules.
Regulators for RSP_2952 (26)
Regulator Module Operator
RSP_0316 237 tf
RSP_0386 237 tf
RSP_0415 237 tf
RSP_0907 237 tf
RSP_1577 237 tf
RSP_1660 237 tf
RSP_2130 237 tf
RSP_2236 237 tf
RSP_3094 237 tf
RSP_3238 237 tf
RSP_3317 237 tf
RSP_3341 237 tf
RSP_3464 237 tf
RSP_3621 237 tf
RSP_3665 237 tf
RSP_3694 237 tf
RSP_0395 261 tf
RSP_0728 261 tf
RSP_1231 261 tf
RSP_1590 261 tf
RSP_1669 261 tf
RSP_1776 261 tf
RSP_1925 261 tf
RSP_2027 261 tf
RSP_2610 261 tf
RSP_2867 261 tf

Warning: RSP_2952 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
8192 1.60e+01 gtgAAAcA
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8193 1.30e+03 ATaTTcT
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8240 2.90e-06 aCAA.c.cggGcA.gAaCCac.Aa
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8241 1.10e+01 CGGAaAGGcatGaTaAGa
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for RSP_2952

RSP_2952 is enriched for 1 functions in 3 categories.
Enrichment Table (1)
Function System
Stress-induced morphogen (activity unknown) cog/ cog
Module neighborhood information for RSP_2952

RSP_2952 has total of 35 gene neighbors in modules 237, 261
Gene neighbors (35)
Gene Common Name Description Module membership
RSP_0029 RSP_0029 acetyl-CoA hydrolase/transferase family protein (NCBI) 203, 261
RSP_0569 RSP_0569 hypothetical protein (NCBI) 237, 366
RSP_0570 RSP_0570 hypothetical protein (NCBI) 237, 366
RSP_0665 ftsH FtsH (NCBI) 237, 365
RSP_0731 RSP_0731 hypothetical protein (NCBI) 173, 261
RSP_0732 RSP_0732 hypothetical protein (NCBI) 173, 261
RSP_0733 RSP_0733 cell division ATP-binding protein FtsE (NCBI) 173, 261
RSP_0734 RSP_0734 cell division protein FtsX (NCBI) 173, 261
RSP_0735 RSP_0735 Phospholipid/glycerol acyltransferase (NCBI) 173, 261
RSP_1204 RSP_1204 ABC multidrug efflux pump, fused ATPase and inner membrane subunits (NCBI) 216, 237
RSP_1743 RSP_1743 ATPase, AAA family (NCBI) 216, 237
RSP_1793 RSP_1793 Single-strand DNA binding protein (NCBI) 48, 261
RSP_1865 RSP_1865 ketol-acid reductoisomerase (NCBI) 261, 356
RSP_1977 cobS cobalt chelatase, CobS small subunit (NCBI) 93, 261
RSP_1978 RSP_1978 molecular chaperone, DnaJ family (NCBI) 93, 261
RSP_1979 RSP_1979 stress induced morphogen, BolA (NCBI) 93, 261
RSP_2092 RSP_2092 Putative uvrD/DNA Helicase II (NCBI) 117, 237
RSP_2095 RSP_2095 Putative MraZ protein (NCBI) 261, 299
RSP_2114 ftsZ1 Cell division protein, FtsZ, GTPase (NCBI) 261, 299
RSP_2126 purC SAICAR synthetase (NCBI) 261, 360
RSP_2127 purS Component of phosphoribosylformylglycinamidine (FGAM) synthetase (NCBI) 107, 261
RSP_2129 RSP_2129 Sensor Histidine kinase (NCBI) 237, 256
RSP_2308 RSP_2308 hypothetical protein (NCBI) 36, 237
RSP_2422 mgpS putative ATP-dependent helicase, MgpS (NCBI) 1, 261
RSP_2505 creA possible CreA protein (NCBI) 10, 237
RSP_2540 tatA twin-arginine translocation system protein, TatA (NCBI) 48, 237
RSP_2543 RSP_2543 Peptidoglycan-binding LysM (possible peptidase) (NCBI) 261, 360
RSP_2641 RSP_2641 hypothetical protein (NCBI) 97, 237
RSP_2887 glgP glycogen phosphorylase (NCBI) 203, 261
RSP_2952 RSP_2952 BolA-like protein (NCBI) 237, 261
RSP_2953 RSP_2953 glutaredoxin-related protein (NCBI) 23, 237
RSP_3210 qxtB Quinol oxidase subunit II QxtB (NCBI) 172, 237
RSP_3212 qxtA Quinol oxidase subunit I QxtA (NCBI) 172, 237
RSP_3562 sqr sulfide-quinone reductase (NCBI) 64, 237
RSP_3835 RSP_3835 hypothetical protein (NCBI) 108, 261
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for RSP_2952
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend