Organism : Bacillus cereus ATCC14579 | Module List :
BC0562

Ca2+/citrate complex secondary transporter (NCBI ptt file)

CircVis
Functional Annotations (5)
Function System
H+/citrate symporter cog/ cog
citrate transmembrane transporter activity go/ molecular_function
citrate transport go/ biological_process
integral to membrane go/ cellular_component
citMHS tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC0562
(Mouseover regulator name to see its description)

BC0562 is regulated by 20 influences and regulates 0 modules.
Regulators for BC0562 (20)
Regulator Module Operator
BC0518 341 tf
BC0613 341 tf
BC0954 341 tf
BC1363 341 tf
BC2218 341 tf
BC2367 341 tf
BC2526 341 tf
BC2904 341 tf
BC3072 341 tf
BC3826 341 tf
BC4010 341 tf
BC5000 341 tf
BC2470 468 tf
BC2551 468 tf
BC3033 468 tf
BC3160 468 tf
BC4001 468 tf
BC4010 468 tf
BC4474 468 tf
BC5463 468 tf

Warning: BC0562 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4594 3.30e+00 aaggGgaAtGg
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4595 1.30e+03 ctC..acTgCc.gcC
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4846 1.40e+04 gaAtaGgaagt
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4847 3.10e+01 cgca.gAatGatgAGgggTt
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC0562

BC0562 is enriched for 5 functions in 3 categories.
Enrichment Table (5)
Function System
H+/citrate symporter cog/ cog
citrate transmembrane transporter activity go/ molecular_function
citrate transport go/ biological_process
integral to membrane go/ cellular_component
citMHS tigr/ tigrfam
Module neighborhood information for BC0562

BC0562 has total of 54 gene neighbors in modules 341, 468
Gene neighbors (54)
Gene Common Name Description Module membership
BC0361 BC0361 Polysaccharide deacetylase (NCBI ptt file) 341, 509
BC0367 BC0367 hypothetical protein (NCBI ptt file) 246, 341
BC0475 BC0475 None 97, 468
BC0562 BC0562 Ca2+/citrate complex secondary transporter (NCBI ptt file) 341, 468
BC0887 BC0887 Collagen adhesion protein (NCBI ptt file) 341, 462
BC0951 BC0951 hypothetical protein (NCBI ptt file) 341, 364
BC0971 BC0971 Carboxylic ester hydrolase (NCBI ptt file) 250, 468
BC1227 BC1227 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 27, 341
BC1245 BC1245 hypothetical protein (NCBI ptt file) 186, 468
BC1250 BC1250 hypothetical protein (NCBI ptt file) 179, 468
BC1358 BC1358 ABC transporter permease protein (NCBI ptt file) 27, 341
BC1359 BC1359 Bacitracin transport ATP-binding protein bcrA (NCBI ptt file) 341, 517
BC1462 BC1462 None 256, 468
BC1893 BC1893 Scaffold protein (NCBI ptt file) 141, 468
BC2033 BC2033 Alkaline phosphatase like protein (NCBI ptt file) 8, 341
BC2095 BC2095 hypothetical protein (NCBI ptt file) 341, 517
BC2184 BC2184 ABC-type transporter ATP-binding protein ecsA (NCBI ptt file) 213, 341
BC2185 BC2185 Protein ecsB (NCBI ptt file) 341, 432
BC2205 BC2205 Acetyltransferase (NCBI ptt file) 266, 341
BC2321 BC2321 tRNA pseudouridine synthase A (NCBI ptt file) 10, 468
BC2399 BC2399 Serine--pyruvate aminotransferase (NCBI ptt file) 204, 341
BC2400 BC2400 Threonine dehydratase (NCBI ptt file) 204, 341
BC2402 BC2402 Tetracycline resistance protein (NCBI ptt file) 130, 468
BC2555 BC2555 hypothetical protein (NCBI ptt file) 76, 468
BC2656 BC2656 Cobalt transport protein cbiQ (NCBI ptt file) 468, 506
BC2690 BC2690 Quaternary ammonium compound-resistance protein (NCBI ptt file) 443, 468
BC2743 BC2743 Carboxylesterase (NCBI ptt file) 341, 478
BC2900 BC2900 CcdC protein (NCBI ptt file) 204, 341
BC2902 BC2902 ABC transporter ATP-binding protein (NCBI ptt file) 60, 341
BC3033 BC3033 Transcriptional regulator, AraC family (NCBI ptt file) 76, 468
BC3058 BC3058 Phosphohydrolase (MutT/nudix family protein) (NCBI ptt file) 341, 462
BC3090 BC3090 hypothetical protein (NCBI ptt file) 341, 498
BC3117 BC3117 Arsenical pump membrane protein (NCBI ptt file) 139, 341
BC3120 BC3120 Succinoglycan biosynthesis protein (NCBI ptt file) 9, 341
BC3195 BC3195 hypothetical Cytosolic Protein (NCBI ptt file) 62, 341
BC3236 BC3236 hypothetical Cytosolic Protein (NCBI ptt file) 225, 468
BC3250 BC3250 hypothetical protein (NCBI ptt file) 214, 341
BC3257 BC3257 N-acetylmuramoyl-L-alanine amidase (NCBI ptt file) 134, 468
BC3622 BC3622 Multidrug resistance protein B (NCBI ptt file) 263, 468
BC4024 BC4024 Phosphohydrolase (MutT/nudix family protein) (NCBI ptt file) 341, 382
BC4216 BC4216 hypothetical protein (NCBI ptt file) 341, 428
BC4219 BC4219 ABC transporter permease protein (NCBI ptt file) 150, 341
BC4687 BC4687 N-acetylmuramoyl-L-alanine amidase (NCBI ptt file) 214, 341
BC4829 BC4829 Ribosomal RNA adenine dimethylase (NCBI ptt file) 402, 468
BC4840 BC4840 ABC transporter permease protein (NCBI ptt file) 312, 341
BC5000 BC5000 Transcriptional regulator, TetR family (NCBI ptt file) 214, 341
BC5001 BC5001 Metal-dependent hydrolase (NCBI ptt file) 214, 341
BC5055 BC5055 Wall-associated protein precursor (NCBI ptt file) 213, 341
BC5175 BC5175 Transcriptional regulators, LysR family (NCBI ptt file) 341, 509
BC5212 BC5212 None 31, 468
BC5225 BC5225 Cytochrome d ubiquinol oxidase subunit II (NCBI ptt file) 402, 468
BC5385 BC5385 Prespore specific transcriptional activator rsfA (NCBI ptt file) 468, 475
BC5425 BC5425 Integral membrane protein (NCBI ptt file) 10, 341
BC5428 BC5428 hypothetical protein (NCBI ptt file) 341, 428
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC0562
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend