Organism : Bacillus cereus ATCC14579 | Module List :
BC0654

Sulfate transporter (NCBI ptt file)

CircVis
Functional Annotations (4)
Function System
Sulfate permease and related transporters (MFS superfamily) cog/ cog
transporter activity go/ molecular_function
transport go/ biological_process
integral to membrane go/ cellular_component
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC0654
(Mouseover regulator name to see its description)

BC0654 is regulated by 29 influences and regulates 0 modules.
Regulators for BC0654 (29)
Regulator Module Operator
BC0116 192 tf
BC0122 192 tf
BC0607 192 tf
BC0657 192 tf
BC0680 192 tf
BC0856 192 tf
BC1841 192 tf
BC2631 192 tf
BC2672 192 tf
BC2770 192 tf
BC3062 192 tf
BC3814 192 tf
BC3826 192 tf
BC3982 192 tf
BC4010 192 tf
BC0059 312 tf
BC0116 312 tf
BC0122 312 tf
BC1337 312 tf
BC1363 312 tf
BC2672 312 tf
BC2770 312 tf
BC3813 312 tf
BC3814 312 tf
BC3982 312 tf
BC4057 312 tf
BC4356 312 tf
BC5143 312 tf
BC5332 312 tf

Warning: BC0654 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4300 8.00e+01 CGTGcAgtcggc
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4301 4.50e+02 gaGGtGGA
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4538 1.40e-01 GaGgAggGg
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4539 2.30e+02 aaAacg.ggc.g.atGaatTTGcC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC0654

BC0654 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Sulfate permease and related transporters (MFS superfamily) cog/ cog
transporter activity go/ molecular_function
transport go/ biological_process
integral to membrane go/ cellular_component
Module neighborhood information for BC0654

BC0654 has total of 33 gene neighbors in modules 192, 312
Gene neighbors (33)
Gene Common Name Description Module membership
BC0504 BC0504 A/G-specific adenine DNA glycosylase (NCBI ptt file) 192, 466
BC0654 BC0654 Sulfate transporter (NCBI ptt file) 192, 312
BC1341 BC1341 Aluminum resistance protein (NCBI ptt file) 192, 476
BC1342 BC1342 6-pyruvoyl tetrahydrobiopterin synthase (NCBI ptt file) 192, 476
BC1343 BC1343 Organic radical activating enzyme (NCBI ptt file) 192, 476
BC1344 BC1344 GTP cyclohydrolase I (NCBI ptt file) 192, 313
BC1553 BC1553 Multimodular transpeptidase-transglycosylase (NCBI ptt file) 176, 192
BC1676 BC1676 hypothetical protein (NCBI ptt file) 312, 428
BC2376 BC2376 hypothetical protein (NCBI ptt file) 221, 312
BC3210 BC3210 hypothetical Cytosolic Protein (NCBI ptt file) 312, 428
BC3553 BC3553 Sodium/pantothenate symporter (NCBI ptt file) 192, 312
BC3554 BC3554 Sodium/pantothenate symporter (NCBI ptt file) 177, 192
BC3775 BC3775 Microsomal dipeptidase (NCBI ptt file) 257, 312
BC3831 BC3831 DNA topoisomerase I (NCBI ptt file) 192, 399
BC3837 BC3837 Signal peptidase I (NCBI ptt file) 312, 366
BC3892 BC3892 Ribosomal large subunit pseudouridine synthase D (NCBI ptt file) 133, 192
BC3893 lspA lipoprotein signal peptidase (RefSeq) 139, 192
BC3911 BC3911 Cell division protein ftsW (NCBI ptt file) 312, 458
BC4000 BC4000 Multidrug resistance protein B (NCBI ptt file) 201, 312
BC4077 BC4077 Acetoin transport ATP-binding protein (NCBI ptt file) 27, 312
BC4078 BC4078 Acetoin transport permease protein (NCBI ptt file) 27, 312
BC4079 BC4079 Acetoin transport permease protein (NCBI ptt file) 27, 312
BC4286 BC4286 NIF3-related protein (NCBI ptt file) 161, 192
BC4287 BC4287 hypothetical Cytosolic Protein (NCBI ptt file) 161, 192
BC4444 BC4444 Rod shape-determining protein mreD (NCBI ptt file) 49, 192
BC4445 BC4445 Rod shape-determining protein mreC (NCBI ptt file) 192, 242
BC4446 BC4446 Rod shape-determining protein mreB (NCBI ptt file) 192, 242
BC4462 BC4462 Septum formation protein Maf (NCBI ptt file) 192, 222
BC4551 BC4551 tRNA pseudouridine synthase A (NCBI ptt file) 245, 312
BC4837 BC4837 ABC transporter permease protein (NCBI ptt file) 312, 479
BC4838 BC4838 ABC transporter permease protein (NCBI ptt file) 27, 312
BC4840 BC4840 ABC transporter permease protein (NCBI ptt file) 312, 341
BC5395 BC5395 Xanthine permease (NCBI ptt file) 312, 482
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC0654
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend