Organism : Bacillus cereus ATCC14579 | Module List :
BC1455

Multimodular transpeptidase-transglycosylase PBP 2A (NCBI ptt file)

CircVis
Functional Annotations (8)
Function System
Membrane carboxypeptidase (penicillin-binding protein) cog/ cog
peptidase activity go/ molecular_function
penicillin binding go/ molecular_function
peptidoglycan biosynthetic process go/ biological_process
peptidoglycan-based cell wall go/ cellular_component
transferase activity, transferring pentosyl groups go/ molecular_function
response to antibiotic go/ biological_process
PBP_1a_fam tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC1455
(Mouseover regulator name to see its description)

BC1455 is regulated by 31 influences and regulates 0 modules.
Regulators for BC1455 (31)
Regulator Module Operator
BC0042 223 tf
BC1131 223 tf
BC1537 223 tf
BC1673 223 tf
BC1724 223 tf
BC1731 223 tf
BC1842 223 tf
BC2904 223 tf
BC3069 223 tf
BC3207 223 tf
BC3389 223 tf
BC3438 223 tf
BC3758 223 tf
BC4101 223 tf
BC4222 223 tf
BC4425 223 tf
BC4650 223 tf
BC5176 223 tf
BC5363 223 tf
BC5481 223 tf
BC0518 256 tf
BC1531 256 tf
BC1673 256 tf
BC2401 256 tf
BC2672 256 tf
BC2979 256 tf
BC3982 256 tf
BC4010 256 tf
BC4256 256 tf
BC4501 256 tf
BC4650 256 tf

Warning: BC1455 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4362 7.90e-05 AGAagaagagA
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4363 2.50e+04 cCTGCTCaTGC
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4428 3.20e-08 gtataaAa.AgaGagGgaa
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4429 7.80e+03 GGGCGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC1455

BC1455 is enriched for 8 functions in 3 categories.
Enrichment Table (8)
Function System
Membrane carboxypeptidase (penicillin-binding protein) cog/ cog
peptidase activity go/ molecular_function
penicillin binding go/ molecular_function
peptidoglycan biosynthetic process go/ biological_process
peptidoglycan-based cell wall go/ cellular_component
transferase activity, transferring pentosyl groups go/ molecular_function
response to antibiotic go/ biological_process
PBP_1a_fam tigr/ tigrfam
Module neighborhood information for BC1455

BC1455 has total of 50 gene neighbors in modules 223, 256
Gene neighbors (50)
Gene Common Name Description Module membership
BC0022 BC0022 Pyrazinamidase (NCBI ptt file) 9, 256
BC0389 BC0389 Spore coat protein B (NCBI ptt file) 223, 437
BC0610 BC0610 Magnesium and cobalt efflux protein corC (NCBI ptt file) 223, 437
BC0812 BC0812 PBS lyase HEAT-like repeat (NCBI ptt file) 62, 256
BC0920 BC0920 hypothetical Cytosolic Protein (NCBI ptt file) 223, 404
BC0932 BC0932 hypothetical protein (NCBI ptt file) 256, 453
BC1042 BC1042 hypothetical Cytosolic Protein (NCBI ptt file) 10, 256
BC1217 BC1217 hypothetical protein (NCBI ptt file) 256, 479
BC1220 BC1220 hypothetical protein (NCBI ptt file) 26, 223
BC1284 BC1284 Immune inhibitor A precursor (NCBI ptt file) 256, 400
BC1455 BC1455 Multimodular transpeptidase-transglycosylase PBP 2A (NCBI ptt file) 223, 256
BC1462 BC1462 None 256, 468
BC1574 BC1574 IAA acetyltransferase (NCBI ptt file) 223, 460
BC1578 BC1578 hypothetical protein (NCBI ptt file) 243, 256
BC1579 BC1579 putative synthetase/amidase (NCBI ptt file) 67, 256
BC1580 BC1580 surface protein (NCBI ptt file) 67, 256
BC1704 BC1704 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 230, 256
BC1796 BC1796 hypothetical protein (NCBI ptt file) 256, 421
BC2061 BC2061 Multidrug resistance protein B (NCBI ptt file) 256, 428
BC2063 BC2063 Alanine racemase (NCBI ptt file) 10, 223
BC2401 BC2401 Transcriptional regulator, MarR family (NCBI ptt file) 222, 256
BC2427 BC2427 hypothetical protein (NCBI ptt file) 223, 255
BC2557 BC2557 Prophage helix-turn-helix protein (NCBI ptt file) 62, 256
BC2583 BC2583 Terminase large subunit (NCBI ptt file) 209, 223
BC2688 BC2688 Penicillin-binding protein (NCBI ptt file) 254, 256
BC2799 BC2799 Macrolide glycosyltransferase (NCBI ptt file) 254, 256
BC2846 BC2846 Protein dltD precursor (NCBI ptt file) 159, 223
BC3110 BC3110 Spore germination protein BC (NCBI ptt file) 10, 256
BC3135 BC3135 Carboxymethylenebutenolidase-related protein (NCBI ptt file) 256, 460
BC3227 BC3227 Two component system histidine kinase (NCBI ptt file) 55, 256
BC3337 BC3337 Acetyltransferase (NCBI ptt file) 202, 223
BC3427 BC3427 Glycosyltransferase (NCBI ptt file) 202, 223
BC3428 BC3428 Lysine exporter protein (NCBI ptt file) 256, 257
BC3430 BC3430 hypothetical protein (NCBI ptt file) 223, 254
BC3496 BC3496 None 223, 347
BC3785 BC3785 3-oxoacyl-[acyl-carrier protein] reductase (NCBI ptt file) 256, 288
BC4205 BC4205 Spore photoproduct lyase (NCBI ptt file) 223, 369
BC4319 BC4319 Spore protease (NCBI ptt file) 202, 223
BC4372 BC4372 Penicillin-binding protein (NCBI ptt file) 223, 404
BC4439 BC4439 Ribonuclease G (NCBI ptt file) 256, 308
BC4466 BC4466 CotS-related protein (NCBI ptt file) 256, 517
BC4535 BC4535 Bacitracin transport permease protein BCRB (NCBI ptt file) 250, 256
BC4650 BC4650 Transcriptional regulators, LysR family (NCBI ptt file) 10, 223
BC4715 BC4715 Glucose 1-dehydrogenase (NCBI ptt file) 150, 256
BC4733 BC4733 Spore germination protein IC (NCBI ptt file) 205, 223
BC4771 BC4771 Sporulation kinase (NCBI ptt file) 60, 223
BC4820 BC4820 hypothetical protein (NCBI ptt file) 172, 223
BC4821 BC4821 hypothetical protein (NCBI ptt file) 172, 223
BC5202 BC5202 UDP-glucose 6-dehydrogenase (NCBI ptt file) 202, 223
BC5412 BC5412 Two-component sensor protein yhcY (NCBI ptt file) 202, 223
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC1455
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend