Organism : Bacillus cereus ATCC14579 | Module List :
BC1565

ATP-dependent helicase, DinG family (NCBI ptt file)

CircVis
Functional Annotations (5)
Function System
Rad3-related DNA helicases cog/ cog
nucleic acid binding go/ molecular_function
ATP binding go/ molecular_function
nucleobase-containing compound metabolic process go/ biological_process
ATP-dependent helicase activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC1565
(Mouseover regulator name to see its description)

BC1565 is regulated by 30 influences and regulates 0 modules.
Regulators for BC1565 (30)
Regulator Module Operator
BC0059 458 tf
BC0116 458 tf
BC0122 458 tf
BC0518 458 tf
BC0613 458 tf
BC1363 458 tf
BC1884 458 tf
BC2514 458 tf
BC2672 458 tf
BC2770 458 tf
BC3593 458 tf
BC3813 458 tf
BC3814 458 tf
BC3826 458 tf
BC4057 458 tf
BC5265 458 tf
BC0122 92 tf
BC0595 92 tf
BC0598 92 tf
BC0993 92 tf
BC1337 92 tf
BC1363 92 tf
BC2218 92 tf
BC2979 92 tf
BC3128 92 tf
BC3814 92 tf
BC3826 92 tf
BC3922 92 tf
BC4652 92 tf
BC5265 92 tf

Warning: BC1565 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4100 1.10e-01 GGGGgA
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4101 4.80e+00 CCTtgTgaataGAatgctaac
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4826 7.10e+01 ttGaaagGAgG
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4827 9.40e+01 ggc.CT.ttCCaTc
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC1565

BC1565 is enriched for 5 functions in 3 categories.
Enrichment Table (5)
Function System
Rad3-related DNA helicases cog/ cog
nucleic acid binding go/ molecular_function
ATP binding go/ molecular_function
nucleobase-containing compound metabolic process go/ biological_process
ATP-dependent helicase activity go/ molecular_function
Module neighborhood information for BC1565

BC1565 has total of 34 gene neighbors in modules 92, 458
Gene neighbors (34)
Gene Common Name Description Module membership
BC0021 BC0021 Deoxyguanosine kinase (NCBI ptt file) 69, 458
BC0121 BC0121 16S rRNA m(2)G 1207 methyltransferase (NCBI ptt file) 92, 366
BC0323 BC0323 Phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI ptt file) 92, 283
BC0324 BC0324 Phosphoribosylaminoimidazole carboxylase ATPase subunit (NCBI ptt file) 92, 283
BC0325 BC0325 Adenylosuccinate lyase (NCBI ptt file) 92, 283
BC1247 BC1247 hypothetical protein (NCBI ptt file) 92, 432
BC1289 BC1289 Spermidine/putrescine-binding protein (NCBI ptt file) 388, 458
BC1290 BC1290 Phosphatidylglycerophosphatase B (NCBI ptt file) 27, 458
BC1565 BC1565 ATP-dependent helicase, DinG family (NCBI ptt file) 92, 458
BC1615 BC1615 Na+ driven multidrug efflux pump (NCBI ptt file) 92, 103
BC1793 BC1793 Chlorohydrolase/deaminase family protein (NCBI ptt file) 92, 133
BC2021 BC2021 High-affinity zinc uptake system protein znuA precursor (NCBI ptt file) 92, 133
BC3177 BC3177 DNA helicase (NCBI ptt file) 92, 143
BC3845 BC3845 Cell division protein ftsY (NCBI ptt file) 92, 476
BC3846 BC3846 Chromosome partition protein smc (NCBI ptt file) 92, 462
BC3911 BC3911 Cell division protein ftsW (NCBI ptt file) 312, 458
BC3922 BC3922 Prespore specific transcriptional activator rsfA (NCBI ptt file) 92, 142
BC4375 BC4375 Uridine kinase (NCBI ptt file) 49, 458
BC4376 BC4376 Protease (NCBI ptt file) 49, 458
BC4507 BC4507 Aquaporin (NCBI ptt file) 92, 133
BC5012 BC5012 Chloramphenicol resistance protein (NCBI ptt file) 92, 133
BC5158 BC5158 Integral membrane protein (NCBI ptt file) 92, 214
BC5218 BC5218 Proton/sodium-glutamate symport protein (NCBI ptt file) 92, 458
BC5235 BC5235 Nucleoside permease nupC (NCBI ptt file) 92, 133
BC5266 BC5266 Heteropolysaccharide repeat unit export protein (NCBI ptt file) 69, 458
BC5267 BC5267 Glycosyltransferase (NCBI ptt file) 69, 458
BC5268 BC5268 Secreted polysaccharide polymerase (NCBI ptt file) 69, 458
BC5269 BC5269 Amylovoran biosynthesis AmsK (NCBI ptt file) 69, 458
BC5270 BC5270 Undecaprenyl-phosphate galactosephosphotransferase (NCBI ptt file) 69, 458
BC5271 BC5271 UDP-N-acetylglucosamine 4-epimerase (NCBI ptt file) 69, 458
BC5272 BC5272 Carbamoyl-phosphate synthase small chain (NCBI ptt file) 69, 458
BC5273 BC5273 UDP-bacillosamine synthetase (NCBI ptt file) 69, 458
BC5455 BC5455 Sporulation kinase (NCBI ptt file) 143, 458
BC5456 BC5456 hypothetical Cytosolic Protein (NCBI ptt file) 143, 458
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC1565
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend