Bacillus subtilis

Model organism for prokaryotic cell differentiation and development

Lineage: Bacteria[3914]; Firmicutes[795]; Bacilli[433]; Bacillales[223]; Bacillaceae[95]; Bacillus[54]; Bacillus subtilis group[7]; Bacillus subtilis[1]Bacillus subtilis. This organism was one of the first bacteria studied, and was named Vibrio subtilis in 1835 and renamed Bacillus subtilis in 1872. It is one of the most well characterized bacterial organisms, and is a model system for cell differentiation and development. This soil bacterium can divide asymmetrically, producing an endospore that is resistant to environmental factors such as heat, acid, and salt, and which can persist in the environment for long periods of time. The endospore is formed at times of nutritional stress, allowing the organism to persist in the environment until conditions become favorable. Prior to the decision to produce the spore the bacterium might become motile, through the production of flagella, and also take up DNA from the environment through the competence system.The sporulation process is complex and involves the coordinated regulation of hundreds of genes in the genome. Environmental signals are sensed by bacterial two-component systems that initiate a phosphorelay that transfers phosphate to one of the key early transcriptional regulators, Spo0A. This initial step results in the coordinated asymmetric cellular division and endospore formation through multiple stages that produces a single spore from the mother cell. This cascade of gene regulation is intensively studied. [Source: NCBI Genome ]

Genes Transcription Factors Network Download (MEME) Data Sources
4313 319 Explore network Motifs 1 Bacillus subtilis (Microbes Online)
Chromosome Length Topology Refseq
chromosome 4214630 circular NC_000964.2
Explore gene functional annotation from any of these systems.
KEGG pathways GO Gene Ontology TIGRFams COGs
KEGG Pathways GO Gene Ontology TIGRFams COGs
Gene Expression Networks Functions/Modules Functions/Gene Genes/Modules
MeV File Cytoscape File Tab-delimited Tab-delimited Tab-delimited