Organism : Clostridium acetobutylicum | Module List :
Regulation information for CAC1441(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Module neighborhood information for CAC1441
|Gene||Common Name||Description||Module membership|
|CAC0159||CAC0159||Hypothetical protein (NCBI ptt file)||47, 334|
|CAC0231||CAC0231||Transcripcional regulator of sugar metabolism (NCBI ptt file)||12, 204|
|CAC0232||fruB||1-phosphofructokinase (fructoso 1-phosphate kinase) (NCBI ptt file)||12, 204|
|CAC0233||CAC0233||PTS system, IIA component (NCBI ptt file)||12, 204|
|CAC0234||CAC0234||PTS system, fructoso-specific IIBC component (NCBI ptt file)||12, 204|
|CAC0299||CAC0299||Protein from nitrogen regulatory protein P-II (GLNB) family, ortholog YAAQ B.subtilis (NCBI ptt file)||47, 334|
|CAC0302||CAC0302||Predicted metal-binding protein of ferredoxin fold (NCBI ptt file)||29, 47|
|CAC0471||CAC0471||GrpE protein HSP-70 cofactor (NCBI ptt file)||47, 221|
|CAC0535||CAC0535||Metal-dependent hydrolase of the beta-lactamase superfamily II (NCBI ptt file)||47, 291|
|CAC0948||CAC0948||Uncharacterized protein, DegV family (NCBI ptt file)||47, 334|
|CAC1282||dnaK||Molecular chaperone DnaK, HSP70 family (NCBI ptt file)||47, 221|
|CAC1284||prmA||SAM-dependent methyltransferase (NCBI ptt file)||47, 137|
|CAC1322||glpA||Glycerol-3-phosphate dehydrogenase, GLPA (NCBI ptt file)||204, 327|
|CAC1324||CAC1324||Uncharacterized predected metal-binding protein (NCBI ptt file)||204, 363|
|CAC1364||CAC1364||Enzyme from phospholipase D family, possible endonuclease nuc (NCBI ptt file)||204, 366|
|CAC1426||CAC1426||Possible transcriptional regulator from leucine-rich protein (LRPR) family (NCBI ptt file)||47, 363|
|CAC1441||CAC1441||Hypothetical protein (NCBI ptt file)||47, 204|
|CAC1454||CAC1454||Membrane associated histidine kinase-like ATPase (NCBI ptt file)||204, 340|
|CAC1455||CAC1455||Two-component system regulator (CheY domain and HTH-like DNA-binding domain) (NCBI ptt file)||204, 340|
|CAC1456||CAC1456||Sugar-binding periplasmic protein (NCBI ptt file)||204, 340|
|CAC1604||CAC1604||Methylglyoxal synthase (NCBI ptt file)||47, 298|
|CAC1964||rpsA||Ribosomal protein S1 (NCBI ptt file)||41, 47|
|CAC2484||CAC2484||Predicted membrane, YQJA B.subtilis ortholog (NCBI ptt file)||47, 292|
|CAC2703||groEL||Chaperonin GroEL, HSP60 family (NCBI ptt file)||204, 271|
|CAC2704||groES||Co-chaperonin GroES, HSP10 family (NCBI ptt file)||204, 271|
|CAC2739||CAC2739||Predicted acetyltransferase (NCBI ptt file)||30, 47|
|CAC2788||CAC2788||Xaa-Pro aminopeptidase family enzyme (NCBI ptt file)||47, 221|
|CAC2810||CAC2810||Possible glucoamylase (diverged), 15 family (NCBI ptt file)||12, 204|
|CAC2827||CAC2827||S-adenosylmethionine-dependent methyltransferase (NCBI ptt file)||80, 204|
|CAC2828||CAC2828||Nudix (MutT) family hydrolase/pyrophosphatase (NCBI ptt file)||80, 204|
|CAC2941||CAC2941||HAD superfamily hydrolase (NCBI ptt file)||47, 279|
|CAC2942||CAC2942||Uncharacterized conserved protein fron YGAG family, predicted metal-dependent enzyme (NCBI ptt file)||47, 63|
|CAC2975||CAC2975||Hypothetical protein (NCBI ptt file)||47, 172|
|CAC2978||gatC||Glu-tRNA amidotransferase, subunit C (NCBI ptt file)||47, 137|
|CAC3190||CAC3190||Arginine kinase related enzyme, YACI B.subtilis ortholog (NCBI ptt file)||47, 221|
|CAC3191||CAC3191||Uncharacterized conserved protein, containing ClpE-like Zn-zinger domain; YACH B.subtilis ortholog (NCBI ptt file)||47, 221|
|CAC3192||CAC3192||Transciptional regulator CTSR (NCBI ptt file)||47, 221|
|CAC3652||alsS||Acetolactate synthase (NCBI ptt file)||47, 363|
|CAC3653||CAC3653||Hypothetical protein (NCBI ptt file)||47, 221|
|CAC3714||CAC3714||Molecular chaperone (small heat shock protein), HSP18 (NCBI ptt file)||47, 221|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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