Organism : Campylobacter jejuni | Module List :
Cj0039c typA

GTP-binding protein typA homolog (NCBI ptt file)

CircVis
Functional Annotations (7)
Function System
Predicted membrane GTPase involved in stress response cog/ cog
GTPase activity go/ molecular_function
GTP binding go/ molecular_function
intracellular go/ cellular_component
translation go/ biological_process
protein-synthesizing GTPase activity go/ molecular_function
small_GTP tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for Cj0039c
(Mouseover regulator name to see its description)

Cj0039c is regulated by 3 influences and regulates 0 modules.
Regulators for Cj0039c typA (3)
Regulator Module Operator
Cj0287c 102 tf
Cj0400 102 tf
Cj1273c 102 tf

Warning: Cj0039c Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
7586 7.50e+04 GcAAAACG
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7587 2.90e+04 GCAGGaaGaTG
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7646 6.10e-02 AgCccCaTCcgcagC
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7647 1.30e+03 GCAaGGtT
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for Cj0039c

Cj0039c is enriched for 7 functions in 3 categories.
Enrichment Table (7)
Function System
Predicted membrane GTPase involved in stress response cog/ cog
GTPase activity go/ molecular_function
GTP binding go/ molecular_function
intracellular go/ cellular_component
translation go/ biological_process
protein-synthesizing GTPase activity go/ molecular_function
small_GTP tigr/ tigrfam
Module neighborhood information for Cj0039c

Cj0039c has total of 45 gene neighbors in modules 102, 132
Gene neighbors (45)
Gene Common Name Description Module membership
Cj0039c typA GTP-binding protein typA homolog (NCBI ptt file) 102, 132
Cj0150c Cj0150c aminotransferase (NCBI ptt file) 94, 102
Cj0235c secG putative protein-export membrane protein (NCBI ptt file) 132, 138
Cj0360 Cj0360 putative phospho-sugar mutase (NCBI ptt file) 74, 102
Cj0398 gatC putative Glu-tRNAGln amidotransferase subunit C (NCBI ptt file) 132, 160
Cj0420 Cj0420 putative periplasmic protein (NCBI ptt file) 102, 127
Cj0428 Cj0428 hypothetical protein Cj0428 (NCBI ptt file) 91, 102
Cj0441 acpP acyl carrier protein (NCBI ptt file) 74, 102
Cj0482 uxaA' putative altronate hydrolase N-terminus (RefSeq) 28, 132
Cj0493 fusA elongation factor G (NCBI ptt file) 52, 132
Cj0538 oorC OORC subunit of 2-oxoglutarate:acceptor oxidoreductase (NCBI ptt file) 74, 102
Cj0555 Cj0555 putative integral membrane protein (NCBI ptt file) 132, 158
Cj0606 Cj0606 putative periplasmic protein (NCBI ptt file) 86, 132
Cj0615 pstA putative phosphate transport system permease protein (NCBI ptt file) 132, 165
Cj0632 ilvC ketol-acid reductoisomerase (NCBI ptt file) 102, 133
Cj0654c Cj0654c None 56, 132
Cj0695 ftsA cell division protein ftsA (NCBI ptt file) 132, 137
Cj0700 Cj0700 hypothetical protein Cj0700 (NCBI ptt file) 8, 102
Cj0705 Cj0705 hypothetical protein Cj0705 (NCBI ptt file) 132, 169
Cj0706 Cj0706 hypothetical protein Cj0706 (NCBI ptt file) 62, 102
Cj0713 trmD tRNA (guanine-N1)-methyltransferase (NCBI ptt file) 132, 160
Cj0787 Cj0787 hypothetical protein Cj0787 (NCBI ptt file) 94, 132
Cj0844c Cj0844c putative integral membrane protein (NCBI ptt file) 34, 102
Cj0898 Cj0898 HIT-family protein (NCBI ptt file) 98, 102
Cj0932c pckA phosphoenolpyruvate carboxykinase (ATP) (NCBI ptt file) 102, 133
Cj0939c Cj0939c hypothetical protein Cj0939c (NCBI ptt file) 47, 132
Cj0978c Cj0978c putative lipoprotein (NCBI ptt file) 18, 132
Cj1011 Cj1011 putative membrane protein (NCBI ptt file) 47, 132
Cj1024c Cj1024c signal-transduction regulatory protein (NCBI ptt file) 132, 160
Cj1059c gatA Glu-tRNAGln amidotransferase subunit A (NCBI ptt file) 34, 102
Cj1070 rpsF 30S ribosomal protein S6 (NCBI ptt file) 83, 102
Cj1110c Cj1110c putative MCP-type signal transduction protein (NCBI ptt file) 74, 102
Cj1111c Cj1111c putative integral membrane protein (NCBI ptt file) 39, 132
Cj1234 glyS glycyl-tRNA synthetase beta chain (NCBI ptt file) 132, 160
Cj1301 Cj1301 hypothetical protein Cj1301 (NCBI ptt file) 120, 132
Cj1364c fumC fumarate hydratase (NCBI ptt file) 102, 133
Cj1405 Cj1405 hypothetical protein Cj1405 (NCBI ptt file) 102, 123
Cj1459 Cj1459 hypothetical protein Cj1459 (NCBI ptt file) 44, 132
Cj1530 Cj1530 putative ATP/GTP-binding protein (NCBI ptt file) 44, 132
Cj1606c mrp putative ATP/GTP-binding protein (mrp protein homolog) (NCBI ptt file) 94, 132
Cj1640 Cj1640 hypothetical protein Cj1640 (NCBI ptt file) 92, 102
Cj1654c nhaA2 Na(+)/H(+) antiporter (NCBI ptt file) 132, 158
Cj1655c nhaA1 Na(+)/H(+) antiporter (NCBI ptt file) 18, 132
Cj1668c Cj1668c putative periplasmic protein (NCBI ptt file) 92, 132
Cjt02 tRNAAsp tRNA-Asp (RefSeq) 42, 132
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for Cj0039c
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend