Organism : Escherichia coli K12 | Module List :
b2190 yejO

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for b2190
(Mouseover regulator name to see its description)

Warning: No Regulators were found for b2190!

Warning: b2190 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
8832 2.10e+03 cccTTT.atgcc.tctGCt
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8833 1.80e+03 cATAAaaaAa.gCT
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9210 5.30e-03 tgCggCagtTCGccaAtaGAt
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9211 1.40e+01 CacaagaacCAtACCgGGAgaggg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for b2190

Warning: No Functional annotations were found!

Module neighborhood information for b2190

b2190 has total of 53 gene neighbors in modules 188, 380
Gene neighbors (53)
Gene Common Name Description Module membership
NP_414611.1 sgrR None 188, 377
NP_414717.2 cdsA None 42, 188
NP_415015.1 ybaP None 257, 380
NP_415060.1 ybcI None 354, 380
NP_415069.1 intD None 78, 188
NP_415143.1 rnk None 188, 250
NP_415283.1 ybhT None 188, 210
NP_415340.1 ybiS None 188, 263
NP_415397.1 ybjD None 144, 380
NP_415447.1 ycbL None 188, 378
NP_415554.4 ycdZ None 380, 408
NP_415786.1 btuR None 106, 188
NP_415796.1 yciM None 95, 188
NP_415851.1 ogt None 188, 327
NP_416088.1 dicA None 157, 188
NP_416320.1 yeaY None 84, 188
NP_416325.1 yoaH None 351, 380
NP_416349.2 rsmF None 59, 380
NP_416369.1 lpxM None 188, 299
NP_416372.1 znuC None 188, 230
NP_416375.1 ruvA None 188, 366
NP_416520.1 yeeZ None 174, 188
NP_416521.2 yefM None 174, 188
NP_416567.4 yegH None 346, 380
NP_416718.1 apbE None 366, 380
NP_416762.2 pmrD None 129, 188
NP_416827.4 mnmC None 380, 408
NP_416905.1 yfeH None 45, 188
NP_417086.1 yfiO None 188, 299
NP_417107.2 smpA None 188, 227
NP_417134.2 ypjA None 380, 408
NP_417270.1 yqcA None 188, 229
NP_417286.1 ygdE None 133, 380
NP_417387.3 ygfA None 188, 329
NP_417614.1 yraK None 167, 380
NP_417807.1 slyX None 76, 380
NP_417808.1 slyD None 21, 380
NP_417809.1 kefB None 21, 380
NP_417810.1 kefG None 21, 380
NP_417811.1 yheS None 21, 380
NP_417812.1 yheT None 21, 380
NP_417813.1 yheU None 21, 380
NP_417927.1 sirA None 106, 380
NP_418002.2 eptB None 188, 361
NP_418099.1 pyrE None 380, 408
NP_418134.1 yidJ None 188, 413
YP_025293.1 setA None 333, 380
YP_026217.1 gntT None 184, 380
YP_026242.1 yieK None 184, 380
YP_026251.1 rep None 22, 380
YP_026264.1 rhtC None 134, 188
b2190 yejO None 188, 380
b3245 b3245 None 380, 411
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for b2190
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend