Organism : Escherichia coli K12 | Module List :
b4405

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for b4405
(Mouseover regulator name to see its description)

Warning: No Regulators were found for b4405!

Warning: b4405 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
8800 1.00e-02 ACAGCctcaTgACaATttcgT
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8801 1.90e+00 atGtgaATtAcaTTtG.caATacC
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9136 6.70e-01 Gcg.gc..AattTtTgaA.c
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9137 1.40e+03 GCctTtgGcGg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for b4405

Warning: No Functional annotations were found!

Module neighborhood information for b4405

b4405 has total of 48 gene neighbors in modules 172, 343
Gene neighbors (48)
Gene Common Name Description Module membership
NP_415201.1 nagD None 144, 343
NP_415282.1 modE None 105, 172
NP_415287.1 ybhA None 144, 343
NP_415572.1 lpxL None 144, 343
NP_415604.1 rluC None 144, 343
NP_415615.1 yceG None 338, 343
NP_415800.1 yciT None 133, 172
NP_415806.1 sapF None 172, 259
NP_415807.1 sapD None 172, 259
NP_415808.1 sapC None 172, 259
NP_415809.1 sapB None 172, 259
NP_415810.1 sapA None 172, 259
NP_415874.1 racR None 171, 172
NP_415875.1 ydaS None 114, 172
NP_415893.1 ynaE None 172, 247
NP_415981.1 yddE None 70, 172
NP_416070.1 cspI None 172, 340
NP_416076.1 cspF None 343, 344
NP_416334.1 yobD None 229, 343
NP_416358.1 exoX None 172, 210
NP_416477.1 yedV None 172, 247
NP_416478.2 yedW None 172, 247
NP_416479.1 yedX None 172, 247
NP_416480.1 yedY None 172, 339
NP_416481.1 yedZ None 172, 247
NP_416482.1 yodA None 172, 247
NP_416483.4 yodB None 172, 247
NP_416570.2 udk None 203, 343
NP_416771.4 rbn None 152, 343
NP_416891.1 ypeC None 114, 172
NP_416966.1 yffB None 133, 343
NP_416967.1 dapE None 84, 343
NP_417004.1 xseA None 56, 343
NP_417027.1 trmJ None 128, 343
NP_417060.1 recO None 343, 409
NP_417278.3 xni None 78, 343
NP_417290.1 csdA None 343, 366
NP_417423.4 yqgE None 171, 172
NP_417424.1 yqgF None 171, 172
NP_417654.1 ispB None 84, 343
NP_418299.1 yihG None 62, 343
NP_418548.1 dcuR None 229, 343
NP_418574.1 ampC None 228, 343
NP_418682.1 yjgP None 343, 393
NP_418747.1 yjiE None 2, 343
YP_025306.1 ydhC None 70, 343
b1362 rzpR None 114, 172
b4405 b4405 None 172, 343
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for b4405
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend