TargetScan_76 megaCluster: 8 Residual: 0.19

Summary

Title	Cluster	Residual	Bicluster Conditions	Residual Permutation P-Value	Var. Exp. First PC	Var. Exp. First PC Perm. P-Value
TargetScan_76	8	0.19	15	0	0.935172	0

Members

Displaying 1 - 45 of 45

TFBS DB TF

TFs	percTargets	pValue
HMX2_homeodomain_DBD_monomeric_11_1	0.136364	0.000036

GO Terms

Displaying 1 - 1 of 1

GO Terms
NA

Upstream MEME Motif

Motif1 E-Value	Motif1 Consensus	Motif1 Matches	Motif2 E-Value	Motif2 Consensus	Motif2 Matches
0.00000057	ARAAAMAAAAT	NA	0.91	GCCACGCCCC	Klf4_MA0039.2, SP1_MA0079.1, SP1_MA0079.2, V$GKLF_02_M01588, V$KLF7_03_M02773, V$SP1_Q6_01_M00931, V$SP4_Q5_M01273, V$SP1_Q6_M00196, V$SP1_Q4_01_M00932, V$CACD_01_M01113, V$GC_01_M00255, V$SP4_03_M02810, V$SP1_Q2_01_M00933, V$SP1_01_M00008, V$SP1_02_M01303, V$EKLF_Q5_M01874, V$KROX_Q6_M00982, V$ZFP281_01_M01597, V$SP1_03_M02281, V$UF1H3BETA_Q6_M01068, V$E2F3_Q6_M02089, V$SP4_04_M02914, V$EGR1_06_M02744, V$SP2_01_M01783, V$CKROX_Q2_M01175, V$KLF15_Q2_M01714, V$MAZR_01_M00491, V$CACCCBINDINGFACTOR_Q6_M00721, V$SMAD4_04_M02898, V$EGR1_Q6_M01873, V$ZFP281_04_M02831, Klf7.1, Sp4.1, Egr1.1, Sp4.2, Smad3.1, Zfp281.2, Zif268.1, Klf7.2, Zfp740.1, Bcl6b.2, Zfp410.1, SP4_C2H2_full_monomeric_17_1, KLF14_C2H2_DBD_monomeric_14_1, KLF16_C2H2_DBD_monomeric_11_1, KLF13_C2H2_full_monomeric_18_1, SP8_C2H2_DBD_monomeric_12_1, SP3_C2H2_DBD_monomeric_11_1, Klf12_C2H2_DBD_monomeric_15_1, SP1_C2H2_DBD_monomeric_11_1, Egr1_C2H2_mouse-DBD_mutant_DBD_monomeric_16_1

Upstream Weeder Motif

Motif1 Score	Motif1 Consensus	Motif1 Matches	Motif2 Score	Motif2 Consensus	Motif2 Matches
1.29	CGGCGA	NA	1.23	CGGCCGTT	NA

3p UTR Weeder

Motif1 E-Value	Motif1 Consensus	Motif1 Matches	Motif1 Model	Motif2 E-Value	Motif2 Consensus	Motif2 Matches	Motif2 Model
0.43	GCGCGA	NA	NA	0.51	TACCGNGT	NA	NA

3p UTR PITA

miRNAs	percTargets	pValue
NA

3p UTR TargetScan

miRNAs	percTargets	pValue
mmu-miR-125b-2-3p	0.45	0.000000835

109145 GINS complex subunit 4 (Sld5 homolog) Details for - - GINS complex subunit 4 (Sld5 homolog) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 109145 Tuberculist Genomic Region	11920 ataxia telangiectasia mutated homolog (human) Details for - - ataxia telangiectasia mutated homolog (human) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 11920 Tuberculist Genomic Region
17346 MAP kinase-interacting serine/threonine kinase 1 Details for RP23-374N19.2 - MAP kinase-interacting serine/threonine kinase 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 17346 Tuberculist Genomic Region	17979 nuclear receptor coactivator 3 Details for RP23-120P1.1 - nuclear receptor coactivator 3 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 17979 Tuberculist Genomic Region
20480 ClpB caseinolytic peptidase B Details for - - ClpB caseinolytic peptidase B GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 20480 Tuberculist Genomic Region	20598 sphingomyelin phosphodiesterase 2, neutral Details for - - sphingomyelin phosphodiesterase 2, neutral GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 20598 Tuberculist Genomic Region
216011 leucine rich repeat containing 20 Details for - - leucine rich repeat containing 20 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 216011 Tuberculist Genomic Region	216527 cerebral cavernous malformation 2 Details for RP23-169J19.3 - cerebral cavernous malformation 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 216527 Tuberculist Genomic Region
218215 ring finger protein 144B Details for - - ring finger protein 144B GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 218215 Tuberculist Genomic Region	21898 toll-like receptor 4 Details for RP24-209H15.1 - toll-like receptor 4 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 21898 Tuberculist Genomic Region
219144 ADP-ribosylation factor-like 11 Details for - - ADP-ribosylation factor-like 11 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 219144 Tuberculist Genomic Region	230996 RIKEN cDNA 9430015G10 gene Details for RP23-139J18.1 - RIKEN cDNA 9430015G10 gene GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 230996 Tuberculist Genomic Region
231279 GUF1 GTPase homolog (S. cerevisiae) Details for - - GUF1 GTPase homolog (S. cerevisiae) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 231279 Tuberculist Genomic Region	231834 sorting nexin 8 Details for - - sorting nexin 8 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 231834 Tuberculist Genomic Region
235461 family with sequence similarity 63, member B Details for - - family with sequence similarity 63, member B GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 235461 Tuberculist Genomic Region	23885 germ cell-less homolog 1 (Drosophila) Details for - - germ cell-less homolog 1 (Drosophila) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 23885 Tuberculist Genomic Region
240068 zinc finger protein 563 Details for RP24-63E7.2 - zinc finger protein 563 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 240068 Tuberculist Genomic Region	242557 autophagy related 4C, cysteine peptidase Details for RP23-59N8.1 - autophagy related 4C, cysteine peptidase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 242557 Tuberculist Genomic Region
27015 polymerase (DNA directed), kappa Details for - - polymerase (DNA directed), kappa GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 27015 Tuberculist Genomic Region	50753 F-box protein 8 Details for - - F-box protein 8 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 50753 Tuberculist Genomic Region
56032 nitrogen permease regulator-like 2 Details for - - nitrogen permease regulator-like 2 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 56032 Tuberculist Genomic Region	56249 ARP8 actin-related protein 8 Details for - - ARP8 actin-related protein 8 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 56249 Tuberculist Genomic Region
56462 mitochondrial carrier homolog 1 (C. elegans) Details for - - mitochondrial carrier homolog 1 (C. elegans) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 56462 Tuberculist Genomic Region	66522 pyroglutamyl-peptidase I Details for - - pyroglutamyl-peptidase I GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 66522 Tuberculist Genomic Region
66609 crystallin, zeta (quinone reductase)-like 1 Details for - - crystallin, zeta (quinone reductase)-like 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 66609 Tuberculist Genomic Region	67698 family with sequence similarity 174, member A Details for - - family with sequence similarity 174, member A GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 67698 Tuberculist Genomic Region
67710 polymerase (RNA) II (DNA directed) polypeptide G Details for - - polymerase (RNA) II (DNA directed) polypeptide G GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 67710 Tuberculist Genomic Region	68041 Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) Details for RP23-130J1.1 - Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68041 Tuberculist Genomic Region
68098 ring finger and CHY zinc finger domain containing 1 Details for - - ring finger and CHY zinc finger domain containing 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68098 Tuberculist Genomic Region	68145 Ewing tumor-associated antigen 1 Details for RP23-353E13.3 - Ewing tumor-associated antigen 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 68145 Tuberculist Genomic Region
69683 ER membrane protein complex subunit 10 Details for - - ER membrane protein complex subunit 10 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 69683 Tuberculist Genomic Region	71538 f-box protein 9 Details for MNCb-2471 - f-box protein 9 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 71538 Tuberculist Genomic Region
71778 kelch-like 5 Details for - - kelch-like 5 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 71778 Tuberculist Genomic Region	791088 RIKEN cDNA C630016N16 gene Details for - - RIKEN cDNA C630016N16 gene GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 791088 Tuberculist Genomic Region
12764 cytidine monophospho-N-acetylneuraminic acid synthetase Details for - - cytidine monophospho-N-acetylneuraminic acid synthetase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 12764 Tuberculist Genomic Region	228545 vacuolar protein sorting 18 (yeast) Details for RP23-46P4.6 - vacuolar protein sorting 18 (yeast) GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 228545 Tuberculist Genomic Region
240034 zinc finger protein 760 Details for - - zinc finger protein 760 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 240034 Tuberculist Genomic Region	14247 Friend leukemia integration 1 Details for - - Friend leukemia integration 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 14247 Tuberculist Genomic Region
16413 integrin beta 1 binding protein 1 Details for - - integrin beta 1 binding protein 1 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 16413 Tuberculist Genomic Region	20226 seryl-aminoacyl-tRNA synthetase Details for RP23-37G19.1 - seryl-aminoacyl-tRNA synthetase GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 20226 Tuberculist Genomic Region
224014 FYVE, RhoGEF and PH domain containing 4 Details for - - FYVE, RhoGEF and PH domain containing 4 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 224014 Tuberculist Genomic Region	26406 mitogen-activated protein kinase kinase kinase 3 Details for RP23-81G14.5 - mitogen-activated protein kinase kinase kinase 3 GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 26406 Tuberculist Genomic Region
26951 zw10 kinetochore protein Details for - - zw10 kinetochore protein GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 26951 Tuberculist Genomic Region	52626 CDKN2A interacting protein N-terminal like Details for RP23-263C23.1 - CDKN2A interacting protein N-terminal like GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 52626 Tuberculist Genomic Region
12576 cyclin-dependent kinase inhibitor 1B Details for - - cyclin-dependent kinase inhibitor 1B GO Terms: NA PATRIC Pathways: [field_patric_pathways] Essentiality: Griffin Essential: [field_griffin_essential] \| In vitro Essential: [field_in_vitro_essential] \| In vivo Essential: [field_in_vivo_essential] Go to Gene Page: 12576 Tuberculist Genomic Region

TargetScan_76 megaCluster: 8 Residual: 0.19

Summary

Members

Details for - - GINS complex subunit 4 (Sld5 homolog)

Details for - - ataxia telangiectasia mutated homolog (human)

Details for RP23-374N19.2 - MAP kinase-interacting serine/threonine kinase 1

Details for RP23-120P1.1 - nuclear receptor coactivator 3

Details for - - ClpB caseinolytic peptidase B

Details for - - sphingomyelin phosphodiesterase 2, neutral

Details for - - leucine rich repeat containing 20

Details for RP23-169J19.3 - cerebral cavernous malformation 2

Details for - - ring finger protein 144B

Details for RP24-209H15.1 - toll-like receptor 4

Details for - - ADP-ribosylation factor-like 11

Details for RP23-139J18.1 - RIKEN cDNA 9430015G10 gene

Details for - - GUF1 GTPase homolog (S. cerevisiae)

Details for - - sorting nexin 8

Details for - - family with sequence similarity 63, member B

Details for - - germ cell-less homolog 1 (Drosophila)

Details for RP24-63E7.2 - zinc finger protein 563

Details for RP23-59N8.1 - autophagy related 4C, cysteine peptidase

Details for - - polymerase (DNA directed), kappa

Details for - - F-box protein 8

Details for - - nitrogen permease regulator-like 2

Details for - - ARP8 actin-related protein 8

Details for - - mitochondrial carrier homolog 1 (C. elegans)

Details for - - pyroglutamyl-peptidase I

Details for - - crystallin, zeta (quinone reductase)-like 1

Details for - - family with sequence similarity 174, member A

Details for - - polymerase (RNA) II (DNA directed) polypeptide G

Details for RP23-130J1.1 - Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

Details for - - ring finger and CHY zinc finger domain containing 1

Details for RP23-353E13.3 - Ewing tumor-associated antigen 1

Details for - - ER membrane protein complex subunit 10

Details for MNCb-2471 - f-box protein 9

Details for - - kelch-like 5

Details for - - RIKEN cDNA C630016N16 gene

Details for - - cytidine monophospho-N-acetylneuraminic acid synthetase

Details for RP23-46P4.6 - vacuolar protein sorting 18 (yeast)

Details for - - zinc finger protein 760

Details for - - Friend leukemia integration 1

Details for - - integrin beta 1 binding protein 1

Details for RP23-37G19.1 - seryl-aminoacyl-tRNA synthetase

Details for - - FYVE, RhoGEF and PH domain containing 4

Details for RP23-81G14.5 - mitogen-activated protein kinase kinase kinase 3

Details for - - zw10 kinetochore protein

Details for RP23-263C23.1 - CDKN2A interacting protein N-terminal like

Details for - - cyclin-dependent kinase inhibitor 1B

GO Terms

3p UTR PITA