Module 349 Residual: 0.51

Title Bicluster Model Residual Score
bicluster_0349 v02 0.51 -4.40
Displaying 1 - 20 of 20
Rv0108c

Details for Rv0108c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.63 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0108c

Tuberculist Genomic Region

Rv1248c Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) / 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)

Details for Rv1248c - Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) / 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)

GO Terms: GO:0000287, GO:0005515, GO:0005886, GO:0006099, GO:0008683, GO:0009055, GO:0040007, GO:0045254, GO:0055114, GO:0004591

PATRIC Pathways: Lysine degradation, Citrate cycle (TCA cycle), Lysine degradation, Citrate cycle (TCA cycle), Tryptophan metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.05 | In vivo Essential: NA

Go to Gene Page: Rv1248c

Tuberculist Genomic Region

Rv1639c

Details for Rv1639c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.70 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1639c

Tuberculist Genomic Region

Rv2302

Details for Rv2302 -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.71 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2302

Tuberculist Genomic Region

Rv2457c ATP-dependent Clp protease ATP-binding subunit ClpX

Details for Rv2457c - ATP-dependent Clp protease ATP-binding subunit ClpX

GO Terms: GO:0046983, GO:0016887, GO:0008270, GO:0019538, GO:0005618, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.17 | In vivo Essential: NA

Go to Gene Page: Rv2457c

Tuberculist Genomic Region

Rv3676 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Details for Rv3676 - cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

GO Terms: GO:0003677, GO:0005886, GO:0045892, GO:0030552, GO:0040007, GO:0042803, GO:0045893

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.31 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3676

Tuberculist Genomic Region

Rv0455c Possible membrane protein

Details for Rv0455c - Possible membrane protein

GO Terms: GO:0005576

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.01 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0455c

Tuberculist Genomic Region

Rv1182 POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA2

Details for Rv1182 - POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA2

GO Terms: GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.99 | In vitro Essential: 0.20 | In vivo Essential: NA

Go to Gene Page: Rv1182

Tuberculist Genomic Region

Rv2632c

Details for Rv2632c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2632c

Tuberculist Genomic Region

Rv3119 Molybdenum cofactor biosynthesis protein MoaE; Molybdopterin converting factor subunit 2

Details for Rv3119 - Molybdenum cofactor biosynthesis protein MoaE; Molybdopterin converting factor subunit 2

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3119

Tuberculist Genomic Region

Rv3120 Possible methyltransferase (EC 2.1.1.-)
Rv3487c putative esterase

Details for Rv3487c - putative esterase

GO Terms: GO:0004091, GO:0004629, GO:0010447, GO:0044119, GO:0052572

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.96 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3487c

Tuberculist Genomic Region

Rv3528c

Details for Rv3528c -

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.01 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3528c

Tuberculist Genomic Region

Rv3588c Carbonic anhydrase (EC 4.2.1.1)

Details for Rv3588c - Carbonic anhydrase (EC 4.2.1.1)

GO Terms: GO:0004089, GO:0004089, GO:0008270, GO:0042803, GO:0051289

PATRIC Pathways: Nitrogen metabolism

Essentiality: Griffin Essential: 0.02 | In vitro Essential: NA | In vivo Essential: 0.36

Go to Gene Page: Rv3588c

Tuberculist Genomic Region

Rv3613c

Details for Rv3613c -

GO Terms: NA

PATRIC Pathways: NA

Essentiality: Griffin Essential: 0.39 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3613c

Tuberculist Genomic Region

Rv3614c ESX-1 secretion system protein (Rv3614c)

Details for Rv3614c - ESX-1 secretion system protein (Rv3614c)

GO Terms: GO:0005515, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.63 | In vitro Essential: NA | In vivo Essential: 0.26

Go to Gene Page: Rv3614c

Tuberculist Genomic Region

Rv3615c Highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection

Details for Rv3615c - Highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection

GO Terms: GO:0009405, GO:0042783

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.94 | In vitro Essential: NA | In vivo Essential: 0.09

Go to Gene Page: Rv3615c

Tuberculist Genomic Region

Rv3616c ESX-1 secretion system protein (Rv3616c)

Details for Rv3616c - ESX-1 secretion system protein (Rv3616c)

GO Terms: GO:0005576, GO:0005886, GO:0009405

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.91 | In vitro Essential: NA | In vivo Essential: 0.14

Go to Gene Page: Rv3616c

Tuberculist Genomic Region

Rv3633 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin

Details for Rv3633 - Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.90 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3633

Tuberculist Genomic Region

Rv3849 ESX-1 secreted protein regulator EspR

Details for Rv3849 - ESX-1 secreted protein regulator EspR

GO Terms: GO:0003677, GO:0005576, GO:0005618, GO:0005829, GO:0005886, GO:0006355, GO:0050708, GO:0052572

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.92 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3849

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 2.4 e-value: 4600
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0008653 | GO:0009103 | GO:0016830 | GO:0016833 lipopolysaccharide metabolic process | lipopolysaccharide biosynthetic process | carbon-carbon lyase activity | oxo-acid-lyase activity
Displaying 1 - 34 of 34
GO:0000287 |

magnesium ion binding

GO:0005515 |

protein binding

GO:0005886 |

plasma membrane

GO:0006099 |

tricarboxylic acid cycle

GO:0008683 |

2-oxoglutarate decarboxylase activity

GO:0009055 |

electron carrier activity

GO:0040007 |

growth

GO:0045254 |

pyruvate dehydrogenase complex

GO:0055114 |

oxidation-reduction process

GO:0004591 |

oxoglutarate dehydrogenase (succinyl-transferring) activity

GO:0046983 |

protein dimerization activity

GO:0016887 |

ATPase activity

GO:0008270 |

zinc ion binding

GO:0019538 |

protein metabolic process

GO:0005618 |

cell wall

GO:0003677 |

DNA binding

GO:0045892 |

negative regulation of transcription, DNA-dependent

GO:0030552 |

cAMP binding

GO:0042803 |

protein homodimerization activity

GO:0045893 |

positive regulation of transcription, DNA-dependent

GO:0005576 |

extracellular region

GO:0004091 |

carboxylesterase activity

GO:0004629 |

phospholipase C activity

GO:0010447 |

response to acidity

GO:0044119 |

growth of symbiont in host cell

GO:0052572 |

response to host immune response

GO:0004089 |

carbonate dehydratase activity

GO:0051289 |

protein homotetramerization

GO:0009405 |

pathogenesis

GO:0042783 |

active evasion of host immune response

GO:0005829 |

cytosol

GO:0006355 |

regulation of transcription, DNA-dependent

GO:0050708 |

regulation of protein secretion