Module 369 Residual: 0.51

Title Bicluster Model Residual Score
bicluster_0369 v02 0.51 -14.41
Displaying 1 - 20 of 20
Rv0410c serine/threonine protein kinase

Details for Rv0410c - serine/threonine protein kinase

GO Terms: GO:0001899, GO:0004674, GO:0005515, GO:0005829, GO:0005886, GO:0006538, GO:0006543, GO:0009405, GO:0040007, GO:0044413, GO:0046777, GO:0052027, GO:0052190, GO:0052369

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.13 | In vivo Essential: NA

Go to Gene Page: Rv0410c

Tuberculist Genomic Region

Rv0411c \Glutamine ABC transporter, periplasmic glutamine-binding protein (TC 3.A.1.3.2)\\\""

Details for Rv0411c - \Glutamine ABC transporter, periplasmic glutamine-binding protein (TC 3.A.1.3.2)\\\""

GO Terms: GO:0005576, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.10 | In vivo Essential: NA

Go to Gene Page: Rv0411c

Tuberculist Genomic Region

Rv0412c Possible membrane protein

Details for Rv0412c - Possible membrane protein

GO Terms: GO:0005887, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.14 | In vivo Essential: NA

Go to Gene Page: Rv0412c

Tuberculist Genomic Region

Rv0440 Heat shock protein 60 family chaperone GroEL

Details for Rv0440 - Heat shock protein 60 family chaperone GroEL

GO Terms: GO:0005515, GO:0005524, GO:0044267, GO:0001666, GO:0005618, GO:0005829, GO:0005886, GO:0009408, GO:0040007, GO:0042803

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv0440

Tuberculist Genomic Region

Rv1464 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily

Details for Rv1464 - Cysteine desulfurase (EC 2.8.1.7), SufS subfamily

GO Terms: GO:0031071, GO:0005515, GO:0005886, GO:0040007

PATRIC Pathways: Thiamine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.03 | In vivo Essential: NA

Go to Gene Page: Rv1464

Tuberculist Genomic Region

Rv2940c Polyketide synthase

Details for Rv2940c - Polyketide synthase

GO Terms: GO:0005618, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2940c

Tuberculist Genomic Region

Rv3801c Long-chain fatty-acid-AMP ligase, Mycobacterial subgroup FadD32

Details for Rv3801c - Long-chain fatty-acid-AMP ligase, Mycobacterial subgroup FadD32

GO Terms: GO:0004467, GO:0005618, GO:0005886, GO:0040007, GO:0070566, GO:0071769

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.02 | In vivo Essential: NA

Go to Gene Page: Rv3801c

Tuberculist Genomic Region

Rv1592c Lipase 1 (EC 3.1.1.3)

Details for Rv1592c - Lipase 1 (EC 3.1.1.3)

GO Terms: NA

PATRIC Pathways: Glycerolipid metabolism

Essentiality: Griffin Essential: 0.96 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1592c

Tuberculist Genomic Region

Rv2243 Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)

Details for Rv2243 - Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)

GO Terms: GO:0004314, GO:0004314, GO:0005515, GO:0006633

PATRIC Pathways: Fatty acid biosynthesis

Essentiality: Griffin Essential: 0.11 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2243

Tuberculist Genomic Region

Rv2244 Acyl carrier protein

Details for Rv2244 - Acyl carrier protein

GO Terms: GO:0048037, GO:0000035, GO:0000036, GO:0005515, GO:0005618, GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.05 | In vitro Essential: 0.20 | In vivo Essential: NA

Go to Gene Page: Rv2244

Tuberculist Genomic Region

Rv2245 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.41)

Details for Rv2245 - 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.41)

GO Terms: GO:0004315, GO:0004315, GO:0005515, GO:0005618, GO:0005829, GO:0005886, GO:0009923, GO:0019367, GO:0030497, GO:0040007

PATRIC Pathways: Fatty acid biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv2245

Tuberculist Genomic Region

Rv2246 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.41)

Details for Rv2246 - 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.41)

GO Terms: GO:0004315, GO:0001666, GO:0004315, GO:0005515, GO:0005618, GO:0005886, GO:0030497, GO:0040007, GO:0071766, GO:0071768

PATRIC Pathways: Fatty acid biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv2246

Tuberculist Genomic Region

Rv2247 Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)

Details for Rv2247 - Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)

GO Terms: GO:0004658, GO:0003989, GO:0005515, GO:0009317, GO:0040007

PATRIC Pathways: Glyoxylate and dicarboxylate metabolism, Propanoate metabolism, Valine, leucine and isoleucine degradation, Reductive carboxylate cycle (CO2 fixation)

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.19 | In vivo Essential: NA

Go to Gene Page: Rv2247

Tuberculist Genomic Region

Rv2453c Molybdopterin-guanine dinucleotide biosynthesis protein MobA

Details for Rv2453c - Molybdopterin-guanine dinucleotide biosynthesis protein MobA

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2453c

Tuberculist Genomic Region

Rv2454c 2-oxoglutarate oxidoreductase, beta subunit (EC 1.2.7.3)

Details for Rv2454c - 2-oxoglutarate oxidoreductase, beta subunit (EC 1.2.7.3)

GO Terms: GO:0047553, GO:0000287, GO:0005618, GO:0005829, GO:0047553

PATRIC Pathways: Citrate cycle (TCA cycle), Reductive carboxylate cycle (CO2 fixation)

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2454c

Tuberculist Genomic Region

Rv2455c 2-oxoglutarate oxidoreductase, alpha subunit (EC 1.2.7.3)

Details for Rv2455c - 2-oxoglutarate oxidoreductase, alpha subunit (EC 1.2.7.3)

GO Terms: GO:0047553, GO:0005886

PATRIC Pathways: Reductive carboxylate cycle (CO2 fixation), Citrate cycle (TCA cycle)

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2455c

Tuberculist Genomic Region

Rv3417c Heat shock protein 60 family chaperone GroEL

Details for Rv3417c - Heat shock protein 60 family chaperone GroEL

GO Terms: GO:0005524, GO:0044267, GO:0005515, GO:0005618, GO:0005886, GO:0009408, GO:0040007, GO:0051260

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.40 | In vitro Essential: 0.17 | In vivo Essential: NA

Go to Gene Page: Rv3417c

Tuberculist Genomic Region

Rv3418c Heat shock protein 60 family co-chaperone GroES

Details for Rv3418c - Heat shock protein 60 family co-chaperone GroES

GO Terms: GO:0005524, GO:0006457, GO:0005576, GO:0005618, GO:0005829, GO:0005886, GO:0009408, GO:0034605, GO:0040007, GO:0006355, GO:0046872, GO:0051260

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.08 | In vitro Essential: 0.07 | In vivo Essential: NA

Go to Gene Page: Rv3418c

Tuberculist Genomic Region

Rv3799c Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)

Details for Rv3799c - Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)

GO Terms: GO:0005515, GO:0005886, GO:0009317, GO:0040007, GO:0071769

PATRIC Pathways: Glyoxylate and dicarboxylate metabolism, Reductive carboxylate cycle (CO2 fixation), Valine, leucine and isoleucine degradation, Propanoate metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.16 | In vivo Essential: NA

Go to Gene Page: Rv3799c

Tuberculist Genomic Region

Rv3800c Probable polyketide synthase, similar to many. e.g. gp|M63676|SERERYAA_1 S.erythraea first ORF of eryA gene, involved in complex polyketide formation in erythromycin biosynthesis.

Details for Rv3800c - Probable polyketide synthase, similar to many. e.g. gp|M63676|SERERYAA_1 S.erythraea first ORF of eryA gene, involved in complex polyketide formation in erythromycin biosynthesis.

GO Terms: GO:0005515, GO:0005618, GO:0005829, GO:0005886, GO:0040007, GO:0071768, GO:0071769

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.05 | In vivo Essential: NA

Go to Gene Page: Rv3800c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 5.1 e-value: 230
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0008610 | GO:0006629 | GO:0016740 | GO:0008168 lipid biosynthetic process | lipid metabolic process | transferase activity | methyltransferase activity
Displaying 1 - 48 of 48
GO:0001899 |

negative regulation of cytolysis by symbiont of host cells

GO:0004674 |

protein serine/threonine kinase activity

GO:0005515 |

protein binding

GO:0005829 |

cytosol

GO:0005886 |

plasma membrane

GO:0006538 |

glutamate catabolic process

GO:0006543 |

glutamine catabolic process

GO:0009405 |

pathogenesis

GO:0040007 |

growth

GO:0044413 |

avoidance of host defenses

GO:0046777 |

protein autophosphorylation

GO:0052027 |

modulation by symbiont of host signal transduction pathway

GO:0052190 |

modulation by symbiont of host phagocytosis

GO:0052369 |

positive regulation by symbiont of defense-related host reactive oxygen species production

GO:0005576 |

extracellular region

GO:0005887 |

integral to plasma membrane

GO:0005524 |

ATP binding

GO:0044267 |

cellular protein metabolic process

GO:0001666 |

response to hypoxia

GO:0005618 |

cell wall

GO:0009408 |

response to heat

GO:0042803 |

protein homodimerization activity

GO:0031071 |

cysteine desulfurase activity

GO:0004467 |

long-chain fatty acid-CoA ligase activity

GO:0070566 |

adenylyltransferase activity

GO:0071769 |

mycolate cell wall layer assembly

GO:0004314 |

[acyl-carrier-protein] S-malonyltransferase activity

GO:0006633 |

fatty acid biosynthetic process

GO:0048037 |

cofactor binding

GO:0000035 |

acyl binding

GO:0000036 |

ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process

GO:0004315 |

3-oxoacyl-[acyl-carrier-protein] synthase activity

GO:0009923 |

fatty acid elongase complex

GO:0019367 |

fatty acid elongation, saturated fatty acid

GO:0030497 |

fatty acid elongation

GO:0071766 |

Actinobacterium-type cell wall biogenesis

GO:0071768 |

mycolic acid biosynthetic process

GO:0004658 |

propionyl-CoA carboxylase activity

GO:0003989 |

acetyl-CoA carboxylase activity

GO:0009317 |

acetyl-CoA carboxylase complex

GO:0047553 |

2-oxoglutarate synthase activity

GO:0000287 |

magnesium ion binding

GO:0051260 |

protein homooligomerization

GO:0006457 |

protein folding

GO:0034605 |

cellular response to heat

GO:0006355 |

regulation of transcription, DNA-dependent

GO:0046872 |

metal ion binding