Rv0820 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1)


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0820 phoT Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) CDS 912726 913502 + 777 258 FALSE

Rv0820 (Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1)) is predicted to be co-regulated in modules bicluster_0268 with residual 0.48 and bicluster_0320 with residual 0.51.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 51.00 and 620.00 for bicluster_0268 and 12.00 and 350.00 for bicluster_0320 respectively.

These modules are enriched for following go terms: phosphorylation, cellular respiration, energy derivation by oxidation of organi... glutamine family amino acid biosynthetic..., glutamine family amino acid metabolic pr....

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Phosphate import ATP-binding protein pstB 1 phosphate ABC transporter ATP-binding protein
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


ABC transporters

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15607960 NP_215335.1 Run

ATP binding

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO Category: 
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ATPase activity

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
GO Category: 
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growth of symbiont in host

growth of symbiont in host

The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
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No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.000000 6.93

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: