Rv1445c 6-phosphogluconolactonase (EC, eukaryotic type


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1445c devB 6-phosphogluconolactonase (EC, eukaryotic type CDS 1623714 1624457 - 744 247 FALSE

Rv1445c (6-phosphogluconolactonase (EC, eukaryotic type) is predicted to be co-regulated in modules bicluster_0444 with residual 0.53 and bicluster_0496 with residual 0.57.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 230.00 and 23,000.00 for bicluster_0444 and 0.00 and 0.00 for bicluster_0496 respectively.

These modules are enriched for following go terms: cellular component organization, cellular component biogenesis, cellular component organization or bioge... sulfur compound metabolic process.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
6-phosphogluconolactonase 6-phosphogluconolactonase
Operon # Operon
965 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


6-phosphogluconolactonase Pentose phosphate pathway
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Pentose phosphate pathway

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Metabolic pathways

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Biosynthesis of secondary metabolites

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Microbial metabolism in diverse environments

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608583 NP_215961.1 Run

6-phosphogluconolactonase activity

6-phosphogluconolactonase activity

Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+).
GO Category: 
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plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
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No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.790000 0.94

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: