Rv1657 Arginine pathway regulatory protein ArgR, repressor of arg regulon


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1657 argR Arginine pathway regulatory protein ArgR, repressor of arg regulon CDS 1870842 1871354 + 513 170 TRUE

Rv1657 (Arginine pathway regulatory protein ArgR, repressor of arg regulon) is predicted to be co-regulated in modules bicluster_0521 with residual 0.55 and bicluster_0572 with residual 0.62.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.01 for bicluster_0521 and 0.00 and 0.00 for bicluster_0572 respectively.

These modules are enriched for following go terms: fatty acid biosynthetic process, monocarboxylic acid biosynthetic process.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 2 of 2
Gene Target Differential Expression Distance Expression pvalue Type
N-acetyl-gamma-glutamyl-phosphate reductase (EC
Induced -17 3.02 1.43e-19 CDS
N-acetyl-gamma-glutamyl-phosphate reductase (EC
Induced -32 3.02 1.43e-19 Internal.TSS
Product (LegacyBRC) Product (RefSeq)
Rv1657 arginine repressor
Operon # Operon
1087 - - - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608795 NP_216173.1 Run

DNA binding

DNA binding

Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
GO Category: 
Total items in this category:  

protein homooligomerization

protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
GO Category: 
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426702 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426703 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426704 GSE59086 25232098 GEO Tiling Array RNA
Experiment UCSC Genome Browser
Rv1657_B190 UCSC Browser Tracks

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.070000 0.51

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated: 0.733065
p-value INH: 0.863117
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 11.14 U
D3I 3 3 3.83 11.47 I
D3U 3 3 3.83 10.85 U
D5I 9 5 6.00 6.89 I
D5U 17 5 6.00 6.71 U
D7I 18 7 8.14 9.78 I
D7U 19 7 8.14 9.86 U
D14I 4 14 15.63 9.94 I
D14U 4 14 15.63 12.13 U
D17I 3 17 19.15 9.77 I
D17U 3 17 19.15 11.10 U
D21I 4 21 23.23 13.06 I
D21U 4 21 23.23 9.81 U
D24I 3 24 26.60 13.72 I
D24U 3 24 26.60 11.95 U
D28I 4 28 30.61 13.28 I
D28U 4 28 30.61 12.21 U