Rv2606c Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-)

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2606c snzP Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-) CDS 2933171 2934070 - 900 299 FALSE

Rv2606c (Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-)) is predicted to be co-regulated in modules bicluster_0155 with residual 0.47 and bicluster_0508 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 4,000.00 and 4,200.00 for bicluster_0155 and 0.00 and 0.00 for bicluster_0508 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Pyridoxal biosynthesis lyase pdxS pyridoxal biosynthesis lyase PdxS
Operon # Operon
1709 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Pentosyltransferases. Butirosin and neomycin biosynthesis, Purine metabolism
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Vitamin B6 metabolism

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609743 NP_217122.1 Run



Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO Category: 
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plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
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No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: