Rv2604c Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-)

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2604c snoP Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-) CDS 2931693 2932289 - 597 198 FALSE

Rv2604c (Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-)) is predicted to be co-regulated in modules bicluster_0177 with residual 0.50 and bicluster_0444 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3.10 and 110.00 for bicluster_0177 and 230.00 and 23,000.00 for bicluster_0444 respectively.

These modules are enriched for following go terms: glutamine metabolic process cellular component organization, cellular component biogenesis, cellular component organization or bioge....

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Glutamine amidotransferase subunit pdxT glutamine amidotransferase subunit PdxT
Operon # Operon
1709 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Pentosyltransferases. Purine metabolism, Butirosin and neomycin biosynthesis
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Vitamin B6 metabolism

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609741 NP_217120.1 Run
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: