Rv2918c [Protein-PII] uridylyltransferase (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2918c glnD [Protein-PII] uridylyltransferase (EC CDS 3228254 3230680 - 2 427 808 FALSE

Rv2918c ([Protein-PII] uridylyltransferase (EC is predicted to be co-regulated in modules bicluster_0163 with residual 0.45 and bicluster_0419 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 280.00 and 3,400.00 for bicluster_0163 and 0.02 and 10.00 for bicluster_0419 respectively.

These modules are enriched for following go terms: [protein-PII] uridylyltransferase activi... .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
[Protein-PII] uridylyltransferase PII uridylyl-transferase
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Two-component system

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610055 NP_217434.1 Run

[protein-PII] uridylyltransferase activity

[protein-PII] uridylyltransferase activity

Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII).
GO Category: 
Total items in this category:  

cell wall

cell wall

The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan.
GO Category: 
Total items in this category:  

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.790000 1.39

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: