Rv3004 Low molecular weight protein antigen 6


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3004 cfp6 Low molecular weight protein antigen 6 CDS 3363348 3363686 + 339 112 FALSE

Rv3004 (Low molecular weight protein antigen 6) is predicted to be co-regulated in modules bicluster_0084 with residual 0.58 and bicluster_0480 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.64 and 170.00 for bicluster_0084 and 0.30 and 53.00 for bicluster_0480 respectively.

These modules are enriched for following go terms: nucleobase-containing compound kinase ac... .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Primary TSS Re-Annotated Start Tuberculist Annotated Start
-0.854 3363309 3363309 3363348
Product (LegacyBRC) Product (RefSeq)
Low molecular weight protein antigen 6 low molecular weight protein antigen 6 (CFP-6)
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610141 NP_217520.1 Run

extracellular region

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.190000 0.82

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: