Rv3156 NADH-ubiquinone oxidoreductase chain L (EC

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3156 nuoL NADH-ubiquinone oxidoreductase chain L (EC CDS 3522234 3524135 + 1 902 633 FALSE

Rv3156 (NADH-ubiquinone oxidoreductase chain L (EC is predicted to be co-regulated in modules bicluster_0165 with residual 0.44 and bicluster_0257 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.03 and 0.07 for bicluster_0165 and 710.00 and 1,500.00 for bicluster_0257 respectively.

These modules are enriched for following go terms: phosphate-containing compound metabolic ..., phosphorus metabolic process, NAD binding phosphate-containing compound metabolic ..., phosphorus metabolic process.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
NADH-quinone oxidoreductase subunit L NADH dehydrogenase subunit L
Operon # Operon
2058 - - - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


NADH dehydrogenase (ubiquinone) Oxidative phosphorylation
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Oxidative phosphorylation

Total items in this category:  


Metabolic pathways

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610292 NP_217672.1 Run

NADH dehydrogenase (ubiquinone) activity

NADH dehydrogenase (ubiquinone) activity

Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
GO Category: 
Total items in this category:  

response to host immune response

response to host immune response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.000000 0.47

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: