Rv3410c Inosine-5'-monophosphate dehydrogenase (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3410c guaB3 Inosine-5'-monophosphate dehydrogenase (EC CDS 3828783 3829910 - 1 128 375 FALSE

Rv3410c (Inosine-5'-monophosphate dehydrogenase (EC is predicted to be co-regulated in modules bicluster_0289 with residual 0.53 and bicluster_0444 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.03 for bicluster_0289 and 230.00 and 23,000.00 for bicluster_0444 respectively.

These modules are enriched for following go terms: oxidoreductase activity, acting on the C..., oxidoreductase activity, acting on CH-OH... cellular component organization, cellular component biogenesis, cellular component organization or bioge....

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Uncharacterized oxidoreductase Rv3410c_MT3518 inosine 5-monophosphate dehydrogenase
Operon # Operon
2231 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


IMP dehydrogenase Purine metabolism, Drug metabolism - other enzymes
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Purine metabolism

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Metabolic pathways

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Biosynthesis of secondary metabolites

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610546 NP_217927.1 Run

IMP dehydrogenase activity

IMP dehydrogenase activity

Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
GO Category: 
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plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
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No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.080000 102.14

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: