Rv3631 Dolichol-phosphate mannosyltransferase (EC in lipid-linked oligosaccharide synthesis cluster


Product Feature Type Start End Strand Length AA Length is TF
Rv3631 Dolichol-phosphate mannosyltransferase (EC in lipid-linked oligosaccharide synthesis... CDS 4070514 4071239 + 726 241 FALSE

Rv3631 (Dolichol-phosphate mannosyltransferase (EC in lipid-linked oligosaccharide synthesis cluster) is predicted to be co-regulated in modules bicluster_0360 with residual 0.56 and bicluster_0572 with residual 0.62.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 20.00 and 61.00 for bicluster_0360 and 0.00 and 0.00 for bicluster_0572 respectively.

These modules are enriched for following go terms: fatty acid biosynthetic process, monocarboxylic acid biosynthetic process.

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Re-Annotated Start Tuberculist Annotated Start
-0.648 4070526 4070514
Product (LegacyBRC) Product (RefSeq)
Operon # Operon
2362 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Dolichyl-phosphate beta-D-mannosyltransferase N-Glycan biosynthesis
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610767 NP_218148.1 Run
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.500000 0.53

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: