Rv3687c Anti-sigma F factor antagonist (spoIIAA-2); Anti-sigma B factor antagonist RsbV


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3687c rsfB Anti-sigma F factor antagonist (spoIIAA-2); Anti-sigma B factor antagonist RsbV CDS 4129323 4129691 - 369 122 FALSE

Rv3687c (Anti-sigma F factor antagonist (spoIIAA-2); Anti-sigma B factor antagonist RsbV) is predicted to be co-regulated in modules bicluster_0104 with residual 0.59 and bicluster_0379 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3,600.00 and 3,500.00 for bicluster_0104 and 8.60 and 9.10 for bicluster_0379 respectively.

These modules are enriched for following go terms: pyrimidine nucleobase biosynthetic proce..., pyrimidine nucleobase metabolic process, nucleobase biosynthetic process NAD(P)+ transhydrogenase activity, oxidoreductase activity, acting on NAD(P....

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
ANTI-ANTI-SIGMA FACTOR RSFB [ANTI-SIGMA FACTOR ANTAGONIST] [REGULATOR OF SIGMA F B] anti-anti-sigma factor RSFB (anti-sigma factor antagonist) (regulator of sigma F B)
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610823 NP_218204.1 Run

protein binding

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO Category: 
Total items in this category:  

anti-sigma factor antagonist activity

anti-sigma factor antagonist activity

The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.430000 1.26

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: