Rv3772 Biosynthetic Aromatic amino acid aminotransferase beta (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3772 hisC2 Biosynthetic Aromatic amino acid aminotransferase beta (EC CDS 4217134 4218195 + 1 062 353 FALSE

Rv3772 (Biosynthetic Aromatic amino acid aminotransferase beta (EC is predicted to be co-regulated in modules bicluster_0123 with residual 0.55 and bicluster_0141 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 2.70 and 4,200.00 for bicluster_0123 and 0.31 and 1,600.00 for bicluster_0141 respectively.

These modules are enriched for following go terms: small molecule biosynthetic process, single-organism biosynthetic process, fatty acid biosynthetic process, carboxylic acid metabolic process, fatty acid synthase activity .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Putative phenylalanine aminotransferase putative aminotransferase
Operon # Operon
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Histidine metabolism

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Tyrosine metabolism

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Phenylalanine metabolism

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Phenylalanine, tyrosine and tryptophan biosynthesis

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Novobiocin biosynthesis

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Metabolic pathways

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Biosynthesis of secondary metabolites

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610908 NP_218289.1 Run
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.920000 1.84

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: