Organism : Pseudomonas aeruginosa | Module List :
PA2939

probable aminopeptidase (NCBI)

CircVis
Functional Annotations (6)
Function System
Predicted aminopeptidases cog/ cog
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity go/ molecular_function
calcium ion binding go/ molecular_function
proteolysis go/ biological_process
peptidase activity go/ molecular_function
membrane go/ cellular_component
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA2939
(Mouseover regulator name to see its description)

PA2939 is regulated by 30 influences and regulates 0 modules.
Regulators for PA2939 (30)
Regulator Module Operator
PA0179 367 tf
PA0225 367 tf
PA1351 367 tf
PA2047 367 tf
PA2320 367 tf
PA2588 367 tf
PA3266 367 tf
PA3285 367 tf
PA3363 367 tf
PA3622 367 tf
PA3921 367 tf
PA4296 367 tf
PA5059 367 tf
PA5105 367 tf
PA0179 349 tf
PA0784 349 tf
PA0961 349 tf
PA1351 349 tf
PA1945 349 tf
PA2047 349 tf
PA2622 349 tf
PA3477 349 tf
PA3596 349 tf
PA3921 349 tf
PA4296 349 tf
PA4703 349 tf
PA4745 349 tf
PA5059 349 tf
PA5261 349 tf
PA5550 349 tf

Warning: PA2939 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3522 1.10e-02 gCcgtCcTTGCGca
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3523 4.90e-03 gTTtTCCccG
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3558 1.00e+03 TC.Ctg.TCAgG
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3559 1.20e+04 ATcATcTAaAGT
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA2939

PA2939 is enriched for 6 functions in 3 categories.
Enrichment Table (6)
Function System
Predicted aminopeptidases cog/ cog
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity go/ molecular_function
calcium ion binding go/ molecular_function
proteolysis go/ biological_process
peptidase activity go/ molecular_function
membrane go/ cellular_component
Module neighborhood information for PA2939

PA2939 has total of 30 gene neighbors in modules 349, 367
Gene neighbors (30)
Gene Common Name Description Module membership
PA0052 PA0052 hypothetical protein (NCBI) 349, 472
PA0109 PA0109 hypothetical protein (NCBI) 349, 382
PA1166 PA1166 hypothetical protein (NCBI) 349, 482
PA1167 PA1167 hypothetical protein (NCBI) 185, 349
PA1353 PA1353 hypothetical protein (NCBI) 349, 482
PA1354 PA1354 hypothetical protein (NCBI) 349, 482
PA1355 PA1355 hypothetical protein (NCBI) 349, 482
PA1356 PA1356 hypothetical protein (NCBI) 349, 482
PA1784 PA1784 hypothetical protein (NCBI) 176, 367
PA1880 PA1880 probable oxidoreductase (NCBI) 64, 367
PA1881 PA1881 probable oxidoreductase (NCBI) 64, 367
PA1914 PA1914 hypothetical protein (NCBI) 367, 392
PA1951 PA1951 hypothetical protein (NCBI) 349, 482
PA2072 PA2072 hypothetical protein (NCBI) 153, 349
PA2571 PA2571 probable two-component sensor (NCBI) 349, 382
PA2699 PA2699 hypothetical protein (NCBI) 345, 367
PA2717 cpo chloroperoxidase precursor (NCBI) 64, 349
PA2927 PA2927 hypothetical protein (NCBI) 367, 472
PA2937 PA2937 hypothetical protein (NCBI) 349, 503
PA2939 PA2939 probable aminopeptidase (NCBI) 349, 367
PA3089 PA3089 hypothetical protein (NCBI) 252, 349
PA3311 PA3311 hypothetical protein (NCBI) 349, 482
PA4648 PA4648 hypothetical protein (NCBI) 367, 392
PA4649 PA4649 hypothetical protein (NCBI) 367, 392
PA4651 PA4651 probable pili assembly chaperone (NCBI) 367, 392
PA4653 PA4653 hypothetical protein (NCBI) 367, 432
PA4925 PA4925 hypothetical protein (NCBI) 84, 349
PA5058 phaC2 poly(3-hydroxyalkanoic acid) synthase 2 (NCBI) 367, 392
PA5059 PA5059 probable transcriptional regulator (NCBI) 367, 482
PA5213 gcvP1 glycine cleavage system protein P1 (NCBI) 294, 367
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA2939
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend