Organism : Pseudomonas aeruginosa | Module List :
PA4902

probable transcriptional regulator (NCBI)

CircVis
Functional Annotations (3)
Function System
Transcriptional regulator cog/ cog
sequence-specific DNA binding transcription factor activity go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA4902
(Mouseover regulator name to see its description)

PA4902 is regulated by 28 influences and regulates 8 modules.
Regulators for PA4902 (28)
Regulator Module Operator
PA0152 536 tf
PA0477 536 tf
PA1264 536 tf
PA1374 536 tf
PA2838 536 tf
PA3398 536 tf
PA3420 536 tf
PA3433 536 tf
PA3757 536 tf
PA4080 536 tf
PA4184 536 tf
PA4902 536 tf
PA5293 536 tf
PA5382 536 tf
PA0191 538 tf
PA1399 538 tf
PA1826 538 tf
PA1945 538 tf
PA1980 538 tf
PA2050 538 tf
PA2093 538 tf
PA3133 538 tf
PA3381 538 tf
PA3596 538 tf
PA4270 538 tf
PA4341 538 tf
PA4902 538 tf
PA5293 538 tf
Regulated by PA4902 (8)
Module Residual Genes
115 0.41 15
167 0.45 13
288 0.43 19
401 0.49 23
409 0.45 14
414 0.48 21
536 0.51 25
538 0.48 22
Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3884 1.80e-13 A.agAaActATc.gcttcA.t.AT
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3885 6.30e-05 aAaaa.aAgAACagg
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3888 1.10e-07 GaTacgCTttctatAAAgAagAa
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3889 4.00e-02 CtGaCcC.cgat.gacAATC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA4902

PA4902 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Transcriptional regulator cog/ cog
sequence-specific DNA binding transcription factor activity go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
Module neighborhood information for PA4902

PA4902 has total of 45 gene neighbors in modules 536, 538
Gene neighbors (45)
Gene Common Name Description Module membership
PA0152 pcaQ transcriptional regulator PcaQ (NCBI) 351, 536
PA0153 pcaH protocatechuate 3,4-dioxygenase, beta subunit (NCBI) 292, 536
PA0154 pcaG protocatechuate 3,4-dioxygenase, alpha subunit (NCBI) 196, 536
PA0239 PA0239 hypothetical protein (NCBI) 266, 536
PA0247 pobA 4-hydroxybenzoate 3-monooxygenase (NCBI) 471, 536
PA0477 PA0477 probable transcriptional regulator (NCBI) 536, 542
PA0529 PA0529 hypothetical protein (NCBI) 34, 536
PA0530 PA0530 probable class III pyridoxal phosphate-dependent aminotransferase (NCBI) 536, 550
PA0531 PA0531 probable glutamine amidotransferase (NCBI) 23, 536
PA1264 PA1264 probable transcriptional regulator (NCBI) 192, 536
PA1265 PA1265 hypothetical protein (NCBI) 333, 536
PA1433 PA1433 hypothetical protein (NCBI) 432, 538
PA1434 PA1434 hypothetical protein (NCBI) 432, 538
PA1435 PA1435 probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor (NCBI) 418, 538
PA1436 PA1436 probable Resistance-Nodulation-Cell Division (RND) efflux transporter (NCBI) 418, 538
PA1437 PA1437 probable two-component response regulator (NCBI) 418, 538
PA1438 PA1438 probable two-component sensor (NCBI) 418, 538
PA2084 PA2084 probable asparagine synthetase (NCBI) 287, 538
PA2085 PA2085 probable ring-hydroxylating dioxygenase small subunit (NCBI) 287, 538
PA2086 PA2086 probable epoxide hydrolase (NCBI) 287, 538
PA2087 PA2087 hypothetical protein (NCBI) 287, 538
PA2090 PA2090 hypothetical protein (NCBI) 287, 538
PA2091 PA2091 hypothetical protein (NCBI) 287, 538
PA2092 PA2092 probable major facilitator superfamily (MFS) transporter (NCBI) 287, 538
PA2093 PA2093 probable sigma-70 factor, ECF subfamily (NCBI) 287, 538
PA3237 PA3237 hypothetical protein (NCBI) 152, 538
PA3398 PA3398 probable transcriptional regulator (NCBI) 536, 542
PA3433 PA3433 probable transcriptional regulator (NCBI) 61, 536
PA3449 PA3449 hypothetical protein (NCBI) 93, 538
PA3561 fruK 1-phosphofructokinase (NCBI) 236, 536
PA3562 PA3562 probable phosphotransferase system enzyme I (NCBI) 236, 536
PA4081 cupB6 fimbrial subunit CupB6 (NCBI) 235, 536
PA4146 PA4146 hypothetical protein (NCBI) 175, 536
PA4184 PA4184 probable transcriptional regulator (NCBI) 61, 536
PA4898 PA4898 probable porin (NCBI) 536, 538
PA4899 PA4899 probable aldehyde dehydrogenase (NCBI) 345, 538
PA4900 PA4900 probable major facilitator superfamily (MFS) transporter (NCBI) 538, 545
PA4901 mdlC benzoylformate decarboxylase (NCBI) 532, 538
PA4902 PA4902 probable transcriptional regulator (NCBI) 536, 538
PA4980 PA4980 probable enoyl-CoA hydratase/isomerase (NCBI) 125, 536
PA5102 PA5102 hypothetical protein (NCBI) 337, 538
PA5293 PA5293 probable transcriptional regulator (NCBI) 394, 536
PA5382 PA5382 probable transcriptional regulator (NCBI) 30, 536
PA5383 PA5383 hypothetical protein (NCBI) 30, 536
PA5388 PA5388 hypothetical protein (NCBI) 236, 536
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA4902
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend