Organism : Bacillus cereus ATCC14579 | Module List :
BC1561

hypothetical Cytosolic Protein (NCBI ptt file)

CircVis
Functional Annotations (1)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC1561
(Mouseover regulator name to see its description)

BC1561 is regulated by 25 influences and regulates 0 modules.
Regulators for BC1561 (25)
Regulator Module Operator
BC0607 10 tf
BC2181 10 tf
BC2631 10 tf
BC2770 10 tf
BC2904 10 tf
BC3653 10 tf
BC3961 10 tf
BC4057 10 tf
BC4204 10 tf
BC4314 10 tf
BC4499 10 tf
BC4650 10 tf
BC5411 10 tf
BC5481 10 tf
BC0648 489 tf
BC1059 489 tf
BC1489 489 tf
BC1531 489 tf
BC2903 489 tf
BC3449 489 tf
BC3702 489 tf
BC3961 489 tf
BC4029 489 tf
BC4336 489 tf
BC4832 489 tf

Warning: BC1561 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3942 1.90e+03 AaAgGa.G
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3943 1.20e+04 gGTtcG.aTgCgA
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4888 8.80e-02 AaGGAGag
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4889 4.20e+04 T.tATcA.TTcTTt.TGttgt
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC1561

BC1561 is enriched for 1 functions in 3 categories.
Enrichment Table (1)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
Module neighborhood information for BC1561

BC1561 has total of 49 gene neighbors in modules 10, 489
Gene neighbors (49)
Gene Common Name Description Module membership
BC0303 BC0303 Alpha/beta hydrolase (NCBI ptt file) 10, 432
BC0416 BC0416 Phage infection protein (NCBI ptt file) 10, 461
BC0454 BC0454 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 10, 281
BC0559 BC0559 Methyl-accepting chemotaxis protein (NCBI ptt file) 489, 517
BC0560 BC0560 Two component system histidine kinase (NCBI ptt file) 489, 516
BC0605 BC0605 hypothetical protein (NCBI ptt file) 155, 489
BC0860 BC0860 Multidrug resistance protein B (NCBI ptt file) 144, 489
BC0881 BC0881 Sensor protein comP (NCBI ptt file) 10, 85
BC1042 BC1042 hypothetical Cytosolic Protein (NCBI ptt file) 10, 256
BC1046 BC1046 hypothetical protein (NCBI ptt file) 9, 489
BC1124 BC1124 Methyl-accepting chemotaxis protein (NCBI ptt file) 428, 489
BC1278 BC1278 Signal peptidase I (NCBI ptt file) 155, 489
BC1561 BC1561 hypothetical Cytosolic Protein (NCBI ptt file) 10, 489
BC1600 BC1600 Ribonuclease H (NCBI ptt file) 454, 489
BC2063 BC2063 Alanine racemase (NCBI ptt file) 10, 223
BC2181 BC2181 Transcriptional regulator, Cro/CI family (NCBI ptt file) 10, 461
BC2318 BC2318 hypothetical protein (NCBI ptt file) 97, 489
BC2321 BC2321 tRNA pseudouridine synthase A (NCBI ptt file) 10, 468
BC2429 BC2429 ABC transporter ATP-binding protein (NCBI ptt file) 10, 276
BC2444 BC2444 Transcription state regulatory protein abrB (NCBI ptt file) 10, 308
BC2461 BC2461 Antigen (NCBI ptt file) 10, 174
BC2601 BC2601 hypothetical protein (NCBI ptt file) 147, 489
BC2607 BC2607 hypothetical protein (NCBI ptt file) 308, 489
BC2696 BC2696 Intein-containing protein (NCBI ptt file) 84, 489
BC2720 BC2720 Transporter (NCBI ptt file) 10, 276
BC2746 BC2746 hypothetical protein (NCBI ptt file) 435, 489
BC2755 BC2755 Integral membrane protein (NCBI ptt file) 10, 148
BC2819 BC2819 hypothetical protein (NCBI ptt file) 85, 489
BC2847 BC2847 Ribosomal-protein-alanine acetyltransferase (NCBI ptt file) 404, 489
BC2862 BC2862 Protein export protein prsA precursor (NCBI ptt file) 10, 265
BC2888 BC2888 Integral membrane protein (NCBI ptt file) 153, 489
BC2895 BC2895 hypothetical protein (NCBI ptt file) 10, 55
BC3110 BC3110 Spore germination protein BC (NCBI ptt file) 10, 256
BC3214 BC3214 hypothetical protein (NCBI ptt file) 30, 489
BC3300 BC3300 hypothetical protein (NCBI ptt file) 10, 404
BC3319 BC3319 hypothetical protein (NCBI ptt file) 289, 489
BC3408 BC3408 Transcriptional regulator, MarR family (NCBI ptt file) 454, 489
BC3449 BC3449 Catabolite gene activator (NCBI ptt file) 454, 489
BC3961 BC3961 putative transcriptional regulator (NCBI ptt file) 364, 489
BC4186 BC4186 Stage III sporulation protein AH (NCBI ptt file) 10, 346
BC4513 BC4513 Chemotaxis motA protein (NCBI ptt file) 248, 489
BC4541 BC4541 Methyltransferase (NCBI ptt file) 10, 265
BC4611 BC4611 Cytosolic protein containing multiple CBS domains (NCBI ptt file) 97, 489
BC4650 BC4650 Transcriptional regulators, LysR family (NCBI ptt file) 10, 223
BC4816 BC4816 hypothetical protein (NCBI ptt file) 276, 489
BC4939 BC4939 Stage 0 sporulation regulatory protein (NCBI ptt file) 10, 62
BC5114 BC5114 hypothetical protein (NCBI ptt file) 489, 498
BC5234 BC5234 N-acetylmuramoyl-L-alanine amidase (NCBI ptt file) 276, 489
BC5425 BC5425 Integral membrane protein (NCBI ptt file) 10, 341
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC1561
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend