Organism : Bacillus cereus ATCC14579 | Module List :
BC2473

Beta-lactamase (NCBI ptt file)

CircVis
Functional Annotations (7)
Function System
Beta-lactamase class A cog/ cog
beta-lactamase activity go/ molecular_function
beta-lactam antibiotic catabolic process go/ biological_process
response to antibiotic go/ biological_process
Penicillin and cephalosporin biosynthesis kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Two-component system kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2473
(Mouseover regulator name to see its description)

BC2473 is regulated by 21 influences and regulates 0 modules.
Regulators for BC2473 (21)
Regulator Module Operator
BC0647 293 tf
BC0648 293 tf
BC0649 293 tf
BC1059 293 tf
BC1282 293 tf
BC1335 293 tf
BC1603 293 tf
BC1698 293 tf
BC1710 293 tf
BC1731 293 tf
BC2470 293 tf
BC3449 293 tf
BC5059 293 tf
BC5361 293 tf
BC5363 293 tf
BC0648 96 tf
BC2340 96 tf
BC4181 96 tf
BC4670 96 tf
BC5175 96 tf
BC5222 96 tf

Warning: BC2473 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4108 2.30e+01 ttAAATa.gGaAgaGgAG
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4109 3.70e+03 GCGGCG
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4502 9.60e+00 TTTaaAAAgGaa.g
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4503 1.50e+04 CCCtCTGC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2473

BC2473 is enriched for 7 functions in 3 categories.
Enrichment Table (7)
Function System
Beta-lactamase class A cog/ cog
beta-lactamase activity go/ molecular_function
beta-lactam antibiotic catabolic process go/ biological_process
response to antibiotic go/ biological_process
Penicillin and cephalosporin biosynthesis kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Two-component system kegg/ kegg pathway
Module neighborhood information for BC2473

BC2473 has total of 40 gene neighbors in modules 96, 293
Gene neighbors (40)
Gene Common Name Description Module membership
BC0455 BC0455 hypothetical Membrane Spanning Protein (NCBI ptt file) 163, 293
BC0463 BC0463 hypothetical protein (NCBI ptt file) 96, 175
BC0582 BC0582 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 96, 218
BC0608 BC0608 Nucleoside permease nupC (NCBI ptt file) 96, 280
BC0737 BC0737 Inosine-5'-monophosphate dehydrogenase related protein (NCBI ptt file) 281, 293
BC0782 BC0782 Spore germination protein, gerB family (NCBI ptt file) 96, 245
BC0811 BC0811 outer surface protein (NCBI ptt file) 255, 293
BC0968 BC0968 putative hydrolase (NCBI ptt file) 96, 487
BC1060 BC1060 Collagen adhesion protein (NCBI ptt file) 60, 293
BC1281 BC1281 Cell envelope-bound metalloprotease (camelysin) (NCBI ptt file) 141, 293
BC1479 BC1479 hypothetical Cytosolic Protein (NCBI ptt file) 96, 461
BC1480 BC1480 Cell wall endopeptidase, family M23/M37 (NCBI ptt file) 25, 96
BC1754 BC1754 hypothetical protein (NCBI ptt file) 13, 96
BC1945 BC1945 Galactoside O-acetyltransferase (NCBI ptt file) 104, 293
BC2219 BC2219 Phenazine biosynthesis protein phzF (NCBI ptt file) 96, 506
BC2236 BC2236 None 96, 281
BC2328 BC2328 Pyruvate oxidase (NCBI ptt file) 96, 179
BC2352 BC2352 hypothetical protein (NCBI ptt file) 104, 293
BC2359 BC2359 CAAX amino terminal protease family (NCBI ptt file) 76, 293
BC2360 BC2360 hypothetical protein (NCBI ptt file) 293, 502
BC2470 BC2470 ECF-type sigma factor negative effector (NCBI ptt file) 85, 293
BC2473 BC2473 Beta-lactamase (NCBI ptt file) 96, 293
BC2528 BC2528 hypothetical protein (NCBI ptt file) 250, 293
BC2530 BC2530 dTDP-glucose 4,6-dehydratase (NCBI ptt file) 181, 293
BC2581 BC2581 Phage endonuclease (NCBI ptt file) 255, 293
BC2682 BC2682 Chitosanase (NCBI ptt file) 293, 340
BC2952 BC2952 enterotoxin / cell-wall binding protein (NCBI ptt file) 96, 150
BC2973 BC2973 Nucleoside permease nupC (NCBI ptt file) 96, 197
BC3038 BC3038 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 96, 153
BC3212 BC3212 Multidrug resistance protein B (NCBI ptt file) 108, 293
BC3254 BC3254 Penicillin acylase II (NCBI ptt file) 293, 469
BC3324 BC3324 hypothetical protein (NCBI ptt file) 26, 293
BC3515 BC3515 hypothetical Glycosyltransferase (NCBI ptt file) 25, 96
BC3988 BC3988 hypothetical protein (NCBI ptt file) 56, 293
BC3991 BC3991 phosphoesterase (NCBI ptt file) 96, 393
BC4113 BC4113 hypothetical protein (NCBI ptt file) 239, 293
BC4291 BC4291 hypothetical protein (NCBI ptt file) 31, 96
BC5081 BC5081 NADH oxidase (NOXASE) (NCBI ptt file) 83, 96
BC5215 BC5215 PTS system, lichenan oligosaccharide-specific IIA component (NCBI ptt file) 239, 293
BC5222 BC5222 Transcriptional regulators, LysR family (NCBI ptt file) 76, 96
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2473
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend