Organism : Bacillus cereus ATCC14579 | Module List :
BC2664

Penicillin-binding protein (NCBI ptt file)

CircVis
Functional Annotations (4)
Function System
Beta-lactamase class C and other penicillin binding proteins cog/ cog
beta-lactamase activity go/ molecular_function
beta-lactam antibiotic catabolic process go/ biological_process
response to antibiotic go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2664
(Mouseover regulator name to see its description)

BC2664 is regulated by 23 influences and regulates 0 modules.
Regulators for BC2664 (23)
Regulator Module Operator
BC0230 520 tf
BC0742 520 tf
BC2469 520 tf
BC2760 520 tf
BC2964 520 tf
BC3095 520 tf
BC3868 520 tf
BC5402 520 tf
BC0114 73 tf
BC0598 73 tf
BC0601 73 tf
BC0613 73 tf
BC0648 73 tf
BC1003 73 tf
BC1884 73 tf
BC2217 73 tf
BC2340 73 tf
BC2362 73 tf
BC2632 73 tf
BC3493 73 tf
BC3982 73 tf
BC4104 73 tf
BC4652 73 tf

Warning: BC2664 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4066 7.90e-02 GAgGtG
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4067 6.90e+01 TaTTTtttCttTttTctAacaaA
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4950 1.10e-02 aA.aAgaGGgg
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4951 5.00e+03 ggTGGtTgg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2664

BC2664 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Beta-lactamase class C and other penicillin binding proteins cog/ cog
beta-lactamase activity go/ molecular_function
beta-lactam antibiotic catabolic process go/ biological_process
response to antibiotic go/ biological_process
Module neighborhood information for BC2664

BC2664 has total of 43 gene neighbors in modules 73, 520
Gene neighbors (43)
Gene Common Name Description Module membership
BC0344 BC0344 Delta-1-pyrroline-5-carboxylate dehydrogenase (NCBI ptt file) 73, 488
BC0386 BC0386 hypothetical protein (NCBI ptt file) 241, 520
BC0511 BC0511 Glutamate synthase [NADPH] large chain (NCBI ptt file) 358, 520
BC0598 BC0598 Transcriptional activator NprR (NCBI ptt file) 73, 488
BC0601 BC0601 Transcriptional activator NprR (NCBI ptt file) 47, 73
BC1063 BC1063 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 59, 520
BC1178 BC1178 hypothetical protein (NCBI ptt file) 20, 73
BC1312 BC1312 3-hydroxybutyryl-CoA dehydratase (NCBI ptt file) 73, 120
BC1313 BC1313 PhaP protein (NCBI ptt file) 73, 120
BC1314 BC1314 PhaQ protein (NCBI ptt file) 73, 120
BC1315 BC1315 PhaQ protein (NCBI ptt file) 73, 120
BC1316 BC1316 PhaR protein (NCBI ptt file) 73, 120
BC1317 BC1317 Acetoacetyl-CoA reductase (NCBI ptt file) 73, 120
BC1318 BC1318 Poly-beta-hydroxybutyrate polymerase (NCBI ptt file) 73, 120
BC1348 BC1348 hypothetical protein (NCBI ptt file) 73, 409
BC1928 BC1928 Branched-chain amino acid transport ATP-binding protein livG (NCBI ptt file) 334, 520
BC1930 BC1930 Branched-chain amino acid transport system permease protein livH (NCBI ptt file) 206, 520
BC1979 BC1979 Siderophore biosynthesis protein (NCBI ptt file) 46, 520
BC1981 BC1981 Acyl carrier protein (NCBI ptt file) 46, 520
BC1982 BC1982 hypothetical protein (NCBI ptt file) 504, 520
BC2005 BC2005 GTPase (NCBI ptt file) 23, 520
BC2109 BC2109 ECF-type sigma factor negative effector (NCBI ptt file) 327, 520
BC2632 BC2632 Transcriptional regulator, AraC family (NCBI ptt file) 73, 434
BC2636 BC2636 hypothetical protein (NCBI ptt file) 46, 520
BC2664 BC2664 Penicillin-binding protein (NCBI ptt file) 73, 520
BC2896 BC2896 Aspartate aminotransferase (NCBI ptt file) 73, 488
BC2897 BC2897 (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase (NCBI ptt file) 73, 488
BC2898 BC2898 Pantothenate kinase (NCBI ptt file) 73, 488
BC3312 BC3312 3-Oxoadipate enol-lactonase (NCBI ptt file) 377, 520
BC3345 BC3345 Collagen-like triple helix repeat protein (NCBI ptt file) 21, 520
BC3502 BC3502 IG hypothetical 17676 (NCBI ptt file) 189, 520
BC3710 BC3710 None 376, 520
BC3903 BC3903 RNA polymerase sigma-G factor (NCBI ptt file) 136, 520
BC3905 BC3905 Sporulation sigma-E factor processing peptidase (NCBI ptt file) 17, 520
BC4427 BC4427 Prephenate dehydratase (NCBI ptt file) 73, 137
BC4938 BC4938 NADH dehydrogenase (NCBI ptt file) 73, 434
BC4971 BC4971 Phosphoglycerate mutase (NCBI ptt file) 73, 422
BC4972 BC4972 DNA-binding protein (NCBI ptt file) 73, 422
BC5076 BC5076 Short chain dehydrogenase (NCBI ptt file) 73, 137
BC5077 BC5077 hypothetical protein (NCBI ptt file) 73, 137
BC5091 BC5091 SnoK-like protein (NCBI ptt file) 73, 120
BC5092 BC5092 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily (NCBI ptt file) 73, 120
BC5224 BC5224 Cytochrome d ubiquinol oxidase subunit I (NCBI ptt file) 378, 520
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2664
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend