Organism : Bacillus cereus ATCC14579 | Module List :
BC5414

GGDEF family protein (NCBI ptt file)

CircVis
Functional Annotations (9)
Function System
FOG: GGDEF domain cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
cellular cell wall organization go/ biological_process
cyclic nucleotide biosynthetic process go/ biological_process
integral to membrane go/ cellular_component
phosphorus-oxygen lyase activity go/ molecular_function
intracellular signal transduction go/ biological_process
GGDEF tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC5414
(Mouseover regulator name to see its description)

BC5414 is regulated by 28 influences and regulates 0 modules.
Regulators for BC5414 (28)
Regulator Module Operator
BC0230 497 tf
BC0499 497 tf
BC0595 497 tf
BC0680 497 tf
BC1080 497 tf
BC1987 497 tf
BC2410 497 tf
BC2672 497 tf
BC2770 497 tf
BC2773 497 tf
BC3062 497 tf
BC3982 497 tf
BC4433 497 tf
BC4652 497 tf
BC5173 497 tf
BC0607 327 tf
BC1113 327 tf
BC1851 327 tf
BC2178 327 tf
BC2401 327 tf
BC2469 327 tf
BC2964 327 tf
BC3332 327 tf
BC3423 327 tf
BC4433 327 tf
BC4525 327 tf
BC4570 327 tf
BC5251 327 tf

Warning: BC5414 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4568 1.60e-03 AgagGAGG
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4569 2.60e+00 AgaTG.aAcAGCAA
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4904 4.50e-03 aatgtAaGGaG
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4905 6.70e+02 GGAGGGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC5414

BC5414 is enriched for 9 functions in 3 categories.
Enrichment Table (9)
Function System
FOG: GGDEF domain cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
cellular cell wall organization go/ biological_process
cyclic nucleotide biosynthetic process go/ biological_process
integral to membrane go/ cellular_component
phosphorus-oxygen lyase activity go/ molecular_function
intracellular signal transduction go/ biological_process
GGDEF tigr/ tigrfam
Module neighborhood information for BC5414

BC5414 has total of 42 gene neighbors in modules 327, 497
Gene neighbors (42)
Gene Common Name Description Module membership
BC0430 BC0430 IG hypothetical 16318 (NCBI ptt file) 333, 497
BC0431 BC0431 Thioredoxin (NCBI ptt file) 333, 497
BC0432 BC0432 hypothetical protein (NCBI ptt file) 333, 497
BC0519 BC0519 Ribosomal-protein-alanine acetyltransferase (NCBI ptt file) 336, 497
BC0571 BC0571 Serine/threonine protein phosphatase (NCBI ptt file) 48, 497
BC0765 BC0765 hypothetical protein (NCBI ptt file) 496, 497
BC1120 BC1120 CAAX amino terminal protease family (NCBI ptt file) 24, 327
BC1121 BC1121 hypothetical protein (NCBI ptt file) 163, 327
BC1122 BC1122 hypothetical protein (NCBI ptt file) 327, 446
BC1192 BC1192 putative competence protein/transcription factor (NCBI ptt file) 497, 508
BC1539 BC1539 hypothetical protein (NCBI ptt file) 186, 327
BC1696 BC1696 hypothetical protein (NCBI ptt file) 398, 497
BC1702 BC1702 hypothetical protein (NCBI ptt file) 184, 497
BC1851 BC1851 Transcriptional regulator (NCBI ptt file) 206, 327
BC1961 BC1961 hypothetical Membrane Spanning Protein (NCBI ptt file) 184, 497
BC2109 BC2109 ECF-type sigma factor negative effector (NCBI ptt file) 327, 520
BC2300 BC2300 Oxalate/formate antiporter (NCBI ptt file) 327, 340
BC2617 BC2617 Cysteine dioxygenase (NCBI ptt file) 199, 327
BC2937 BC2937 Acetyltransferase (NCBI ptt file) 24, 327
BC2947 BC2947 Isochorismatase (NCBI ptt file) 98, 327
BC3017 BC3017 hypothetical Secreted Protein (NCBI ptt file) 327, 446
BC3018 BC3018 MoxR protein (NCBI ptt file) 106, 327
BC3082 BC3082 Ribosomal-protein-alanine acetyltransferase (NCBI ptt file) 327, 456
BC3100 BC3100 Sporulation kinase (NCBI ptt file) 496, 497
BC3330 BC3330 hypothetical protein (NCBI ptt file) 454, 497
BC3351 BC3351 hypothetical protein (NCBI ptt file) 333, 497
BC3352 BC3352 hypothetical protein (NCBI ptt file) 184, 497
BC3586 BC3586 Oligopeptide-binding protein oppA (NCBI ptt file) 317, 327
BC3742 BC3742 DNA-3-methyladenine glycosylase II (NCBI ptt file) 327, 337
BC4615 BC4615 hypothetical protein (NCBI ptt file) 496, 497
BC4616 BC4616 hypothetical protein (NCBI ptt file) 496, 497
BC4679 BC4679 hypothetical protein (NCBI ptt file) 333, 497
BC4680 BC4680 hypothetical protein (NCBI ptt file) 333, 497
BC4681 BC4681 hypothetical protein (NCBI ptt file) 333, 497
BC4777 BC4777 hypothetical protein (NCBI ptt file) 333, 497
BC5169 BC5169 hypothetical protein (NCBI ptt file) 13, 327
BC5252 BC5252 hypothetical Membrane Spanning Protein (NCBI ptt file) 327, 340
BC5253 BC5253 ABC transporter permease protein (NCBI ptt file) 327, 405
BC5254 BC5254 ABC transporter ATP-binding protein (NCBI ptt file) 141, 327
BC5255 BC5255 periplasmic component of efflux system (NCBI ptt file) 327, 405
BC5303 BC5303 Integral membrane protein (NCBI ptt file) 141, 327
BC5414 BC5414 GGDEF family protein (NCBI ptt file) 327, 497
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC5414
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend