Organism : Bacillus subtilis | Module List :
BSU16030 trmD

tRNA (guanine-N(1)-)-methyltransferase (RefSeq)

CircVis
Functional Annotations (5)
Function System
tRNA-(guanine-N1)-methyltransferase cog/ cog
RNA binding go/ molecular_function
tRNA processing go/ biological_process
tRNA (guanine-N1-)-methyltransferase activity go/ molecular_function
trmD tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU16030
(Mouseover regulator name to see its description)

BSU16030 is regulated by 22 influences and regulates 0 modules.
Regulators for BSU16030 trmD (22)
Regulator Module Operator
BSU04060 125 tf
BSU05130 125 tf
BSU09560 125 tf
BSU13150 125 tf
BSU15330 125 tf
BSU23100 125 tf
BSU30020 125 tf
BSU34220 125 tf
BSU36020 125 tf
BSU40010 125 tf
BSU00830 245 tf
BSU10560 245 tf
BSU10860 245 tf
BSU15880 245 tf
BSU16600 245 tf
BSU22120 245 tf
BSU23210 245 tf
BSU24320 245 tf
BSU29740 245 tf
BSU30020 245 tf
BSU35200 245 tf
BSU37080 245 tf

Warning: BSU16030 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5202 2.60e+00 tTtaCAgAagggGgg
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5203 5.70e+03 T.CCcTCaTtT
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5432 7.20e+01 GaaAAagAAggaaAtGtgC
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5433 2.50e+04 aGGGGA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU16030

BSU16030 is enriched for 5 functions in 3 categories.
Enrichment Table (5)
Function System
tRNA-(guanine-N1)-methyltransferase cog/ cog
RNA binding go/ molecular_function
tRNA processing go/ biological_process
tRNA (guanine-N1-)-methyltransferase activity go/ molecular_function
trmD tigr/ tigrfam
Module neighborhood information for BSU16030

BSU16030 has total of 41 gene neighbors in modules 125, 245
Gene neighbors (41)
Gene Common Name Description Module membership
BSU02780 ycdA putative lipoprotein (RefSeq) 60, 245
BSU04140 pbpC penicillin-binding lipoprotein 3 (RefSeq) 80, 245
BSU04620 acpS 4'-phosphopantetheinyl transferase (RefSeq) 245, 255
BSU05900 thiL thiamine monophosphate kinase (RefSeq) 1, 245
BSU10770 wprA cell wall-associated protease (RefSeq) 125, 276
BSU13550 mtnA methylthioribose-1-phosphate isomerase (RefSeq) 28, 125
BSU13560 mtnK methylthioribose kinase (RefSeq) 28, 125
BSU15930 rnc ribonuclease III (RefSeq) 245, 343
BSU15940 smc chromosome condensation and segregation SMC ATPase (RefSeq) 142, 245
BSU15950 ftsY signal recognition particle (docking protein) (RefSeq) 125, 245
BSU16010 ylqD hypothetical protein (RefSeq) 245, 253
BSU16020 rimM 16S rRNA-processing protein RimM (RefSeq) 125, 253
BSU16030 trmD tRNA (guanine-N(1)-)-methyltransferase (RefSeq) 125, 245
BSU16920 pgsA CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (RefSeq) 48, 245
BSU16930 cinA competence damage-inducible protein A (RefSeq) 48, 245
BSU16970 ymdB hypothetical protein (RefSeq) 32, 245
BSU17040 mutS DNA mismatch repair protein MutS (RefSeq) 79, 245
BSU27700 yajC preprotein translocase subunit YajC (RefSeq) 221, 245
BSU27730 ruvB Holliday junction DNA helicase RuvB (RefSeq) 221, 245
BSU27740 ruvA Holliday junction DNA helicase RuvA (RefSeq) 221, 245
BSU28080 folC folyl-polyglutamate synthase (RefSeq) 245, 343
BSU28090 valS valyl-tRNA synthetase (RefSeq) 245, 343
BSU30410 ytrF metabolite permease (RefSeq) 125, 190
BSU30420 ytrE ABC transporter (ATP-binding protein) (RefSeq) 125, 190
BSU32200 yutJ putative NADH dehydrogenase (RefSeq) 187, 245
BSU33260 yvrN putative ABC transporter (ATP-binding protein) (RefSeq) 125, 155
BSU33270 yvrO putative ABC transporter (ATP-binding protein) (RefSeq) 125, 155
BSU33280 yvrP putative ABC transporter component (RefSeq) 125, 155
BSU36370 fabZ (3R)-hydroxymyristoyl-ACP dehydratase (RefSeq) 128, 245
BSU39110 deaD ATP-dependent RNA helicase (RefSeq) 125, 158
BSU39120 yxiM putative esterase (lipoprotein) (RefSeq) 125, 158
BSU39140 yxiK putative phage head maturation protein (RefSeq) 125, 158
BSU39150 yxiJ hypothetical protein (RefSeq) 125, 158
BSU39160 yxiI hypothetical protein (RefSeq) 125, 158
BSU39170 yxzG putative nucleic acid binding protein (RefSeq) 125, 158
BSU39180 yxiH hypothetical protein (RefSeq) 125, 158
BSU39190 yxiG hypothetical protein (RefSeq) 125, 158
BSU39200 yxzC putative nucleic acid binding protein (RefSeq) 125, 158
BSU39210 yxiF putative phage reverse transcriptase or polymerase (RefSeq) 125, 158
BSU39220 yxxG hypothetical protein (RefSeq) 125, 158
BSU39230 wapA cell wall-associated protein precursor (RefSeq) 125, 158
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU16030
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend