Organism : Bacillus subtilis | Module List :
BSU09560 cueR

copper efflux transcriptional regulator (RefSeq)

CircVis
Functional Annotations (5)
Function System
Predicted transcriptional regulators cog/ cog
nucleotide binding go/ molecular_function
sequence-specific DNA binding transcription factor activity go/ molecular_function
nucleus go/ cellular_component
regulation of transcription, DNA-dependent go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU09560
(Mouseover regulator name to see its description)

BSU09560 is regulated by 22 influences and regulates 15 modules.
Regulators for BSU09560 cueR (22)
Regulator Module Operator
BSU03470 31 tf
BSU05580 31 tf
BSU09430 31 tf
BSU09560 31 tf
BSU15640 31 tf
BSU19120 31 tf
BSU31530 31 tf
BSU36020 31 tf
BSU37650 31 tf
BSU00830 354 tf
BSU04680 354 tf
BSU05130 354 tf
BSU06960 354 tf
BSU09560 354 tf
BSU13760 354 tf
BSU23520 354 tf
BSU24020 354 tf
BSU25490 354 tf
BSU25810 354 tf
BSU31530 354 tf
BSU36020 354 tf
BSU38600 354 tf

Warning: BSU09560 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5022 4.20e+00 aAAAGcTtTtGAagt
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5023 2.40e+04 caa.aCcCCttTCaT
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5632 3.80e-01 aAAGGAaG
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5633 5.60e+04 GGaCGGAATGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU09560

BSU09560 is enriched for 5 functions in 3 categories.
Enrichment Table (5)
Function System
Predicted transcriptional regulators cog/ cog
nucleotide binding go/ molecular_function
sequence-specific DNA binding transcription factor activity go/ molecular_function
nucleus go/ cellular_component
regulation of transcription, DNA-dependent go/ biological_process
Module neighborhood information for BSU09560

BSU09560 has total of 52 gene neighbors in modules 31, 354
Gene neighbors (52)
Gene Common Name Description Module membership
BSU00670 tilS tRNAile lysidine synthetase (RefSeq) 82, 354
BSU01560 kbaA inner membrane protein involved in activation of the KinB signaling pathway to sporulation (RefSeq) 31, 359
BSU04790 ydcK hypothetical protein (RefSeq) 82, 354
BSU05610 vmlR ATP-binding cassette efflux transporter (RefSeq) 111, 354
BSU07490 yfmF iron-dicitrate ABC transporter (ATP-binding protein) (RefSeq) 31, 151
BSU07690 yflG methionine aminopeptidase (RefSeq) 82, 354
BSU08560 yfhJ hypothetical protein (RefSeq) 109, 354
BSU08620 yfhP putative membrane hydrolase (RefSeq) 82, 354
BSU08680 ygaC hypothetical protein (RefSeq) 262, 354
BSU08900 yhzB hypothetical protein (RefSeq) 109, 354
BSU09550 yhdP putative transporter or sensor (RefSeq) 31, 259
BSU09560 cueR copper efflux transcriptional regulator (RefSeq) 31, 354
BSU09860 khtT K+/H+ antiporter for K+ efflux (RefSeq) 31, 70
BSU09870 khtS K+/H+ antiporter for K+ efflux (RefSeq) 31, 70
BSU10000 yhaH putative membrane protein; acid tolerance protein (RefSeq) 323, 354
BSU10040 ecsA ABC transporter (ATP-binding protein) (RefSeq) 31, 381
BSU10050 ecsB ABC transporter (membrane protein) (RefSeq) 31, 341
BSU11520 mecA adaptor protein (RefSeq) 82, 354
BSU11560 yjbI putative thiol management oxidoreductase component (RefSeq) 82, 354
BSU11630 yjbP bis(5'-nucleosyl)-tetraphosphatase PrpE (RefSeq) 31, 378
BSU11970 yjcS hypothetical protein (RefSeq) 31, 274
BSU19460 yojG putative deacetylase (RefSeq) 197, 354
BSU19470 yojF hypothetical protein (RefSeq) 82, 354
BSU23660 yqkB hypothetical protein (RefSeq) 82, 354
BSU23990 yqiW hypothetical protein (RefSeq) 31, 78
BSU24010 bmr multidrug-efflux transporter (RefSeq) 82, 354
BSU24020 bmrR transcriptional regulator (MerR family) (RefSeq) 82, 354
BSU25850 yqzI hypothetical protein; skin element (RefSeq) 31, 379
BSU25860 yqcG putative phage DNA manipulating enzyme; skin element (RefSeq) 31, 91
BSU25870 yqcF hypothetical protein; skin element (RefSeq) 31, 91
BSU26450 yrkN putative N-acetyltransferase (RefSeq) 31, 263
BSU29620 hisJ histidinol-phosphatase (RefSeq) 31, 53
BSU31160 yubA putative integral inner membrane protein (RefSeq) 31, 63
BSU31520 yufL sensory histidine kinase DcuS (RefSeq) 82, 354
BSU31530 yufM two-component response regulator [YufL] (RefSeq) 82, 354
BSU31780 yueH hypothetical protein (RefSeq) 31, 160
BSU31810 yuzE hypothetical protein (RefSeq) 31, 378
BSU31820 yuzF hypothetical protein (RefSeq) 82, 354
BSU31830 yueE putative metal-dependent phosphohydrolase (RefSeq) 82, 354
BSU31910 yukE hypothetical protein (RefSeq) 31, 296
BSU32060 yuiD putative integral inner membrane protein (RefSeq) 354, 381
BSU32770 yusE putative thiol-disulfide oxidoreductase with thioredoxin domain (RefSeq) 111, 354
BSU32780 yusF putative ribonuclease (RefSeq) 109, 354
BSU32960 yusY hypothetical protein (RefSeq) 31, 262
BSU32970 yusY hypothetical protein (RefSeq) 31, 52
BSU33020 cssS two-component sensor histidine kinase (RefSeq) 310, 354
BSU33420 nhaK Na+/H+ antiporter (RefSeq) 31, 123
BSU33520 csoR repressor of copper utilisation proteins (RefSeq) 82, 354
BSU35140 yvkN hypothetical protein (RefSeq) 31, 166
BSU37640 ywfL hypothetical protein (RefSeq) 7, 31
BSU37650 cysL regulator of sulfur assimilation CysL, activates cysJI expression (RefSeq) 31, 353
BSU38030 ywdA hypothetical protein (RefSeq) 31, 263
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU09560
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend