Organism : Bacillus subtilis | Module List :
BSU18930 yobH

putative DNA repair protein (RefSeq)

CircVis
Functional Annotations (1)
Function System
DNA repair go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU18930
(Mouseover regulator name to see its description)

BSU18930 is regulated by 19 influences and regulates 0 modules.
Regulators for BSU18930 yobH (19)
Regulator Module Operator
BSU09520 181 tf
BSU16600 181 tf
BSU18760 181 tf
BSU19090 181 tf
BSU25760 181 tf
BSU26430 181 tf
BSU29740 181 tf
BSU36420 181 tf
BSU37160 181 tf
BSU03890 86 tf
BSU05970 86 tf
BSU06540 86 tf
BSU09480 86 tf
BSU18760 86 tf
BSU26320 86 tf
BSU26340 86 tf
BSU26430 86 tf
BSU30150 86 tf
BSU36600 86 tf

Warning: BSU18930 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5126 2.60e+03 AGGAGG
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5127 4.00e+03 CaGGctGaCGC
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5310 3.60e-11 GAAcGTTTGTtCtGTtaATATtAG
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5311 1.20e-12 ACAAAAGTTCGATGTAAATGTTGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU18930

BSU18930 is enriched for 1 functions in 2 categories.
Enrichment Table (1)
Function System
DNA repair go/ biological_process
Module neighborhood information for BSU18930

BSU18930 has total of 28 gene neighbors in modules 86, 181
Gene neighbors (28)
Gene Common Name Description Module membership
BSU01590 ybaS putative sodium dependent transporter (RefSeq) 86, 231
BSU02220 ybfI putative transcriptional regulator (AraC/XylS family, cupin family) (RefSeq) 86, 141
BSU02490 gudD glucarate dehydratase (RefSeq) 86, 168
BSU05730 ydhF putative lipoprotein (RefSeq) 86, 358
BSU05740 phoB alkaline phosphatase III (RefSeq) 86, 411
BSU07320 yfnC putative efflux transporter (RefSeq) 86, 311
BSU09030 yhcC hypothetical protein (RefSeq) 86, 295
BSU09040 yhcD hypothetical protein (RefSeq) 86, 285
BSU09360 yhdC hypothetical protein (RefSeq) 181, 282
BSU18930 yobH putative DNA repair protein (RefSeq) 86, 181
BSU18940 yozK putative DNA repair protein fragment (RefSeq) 83, 181
BSU18950 yozL hypothetical protein (RefSeq) 47, 181
BSU18960 yozM putative bacteriophage protein (RefSeq) 129, 181
BSU19810 ypqP hypothetical protein (RefSeq) 86, 326
BSU19930 yotC hypothetical protein; phage SPbeta (RefSeq) 86, 242
BSU20220 yorX hypothetical protein; phage SPbeta (RefSeq) 86, 376
BSU21500 uvrX lesion bypass phage DNA polymerase (RefSeq) 181, 337
BSU21510 yolD conserved hypothetical protein; phage SPbeta (RefSeq) 181, 337
BSU21520 yolC SP beta phage protein (RefSeq) 181, 337
BSU24510 yqhO hypothetical protein (RefSeq) 33, 86
BSU25420 yqeW putative Na+/anion cotransporter (RefSeq) 86, 150
BSU25940 yqcD conserved hypothetical protein; skin element (RefSeq) 86, 222
BSU26400 yrkS hypothetical protein (RefSeq) 181, 217
BSU26570 yrkB hypothetical protein (RefSeq) 86, 222
BSU26940 yraH putative lyase (RefSeq) 86, 239
BSU30640 ytkC putative autolytic amidase (RefSeq) 86, 387
BSU32510 pucA xanthine dehydrogenase molybdopterin recruitment factor (RefSeq) 86, 231
BSU37750 ywfA putative efflux transporter (RefSeq) 86, 310
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU18930
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend